INT47719

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Context Info
Confidence 0.00
First Reported 1995
Last Reported 1995
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) signal transduction (Gpr143) oxidoreductase activity (Grhpr)
Golgi apparatus (Gpr143) plasma membrane (Gpr143) cytoplasm (Grhpr)
Anatomy Link Frequency
liver 2
Gpr143 (Mus musculus)
Grhpr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 84.72 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OA produced a dose-dependent reduction in liver microsomal cytochrome P450 (P450) levels (25-37%) and cytochrome b5 (15-21%) content, but had no effect on NADPH-cytochrome c reductase activity.
OA Neg (no) Regulation (effect) of reductase in liver
1) Confidence 0.00 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7473165 Disease Relevance 0.08 Pain Relevance 0.08
OA treatment slightly increased liver glutathione (GSH) content and the activity of GSH S-transferases toward 1-chloro-2,4-dinitrobenzene, but had no effect on GSH peroxidase and GSH reductase.
OA Neg (no) Regulation (effect) of reductase in liver
2) Confidence 0.00 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7473165 Disease Relevance 0 Pain Relevance 0

General Comments

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