INT47734

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Context Info
Confidence 0.56
First Reported 1995
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 13.16
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAPGEF5) intracellular (RAPGEF5)
Anatomy Link Frequency
plasma 1
superior 1
RAPGEF5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 3 99.88 Very High Very High Very High
adenocard 8 99.30 Very High Very High Very High
bradykinin 1 99.08 Very High Very High Very High
ischemia 7 97.64 Very High Very High Very High
fibrosis 8 92.12 High High
corticosteroid 6 91.28 High High
narcan 7 87.32 High High
Pain 22 85.80 High High
beta blocker 30 85.60 High High
aspirin 16 80.52 Quite High
Disease Link Frequency Relevance Heat
Proteinuria 22 99.96 Very High Very High Very High
Disorders Of Creatine Metabolism 54 99.88 Very High Very High Very High
Disease 87 99.44 Very High Very High Very High
Nicotine Addiction 130 99.32 Very High Very High Very High
Renal Disease 300 99.16 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 111 98.64 Very High Very High Very High
Cv Unclassified Under Development 24 97.64 Very High Very High Very High
Renal Failure 34 97.46 Very High Very High Very High
Hypertension 176 93.84 High High
Nephrogenic Fibrosing Dermopathy 5 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the cadmium-associated increase in GFR, occurring in the next highest cadmium stratum (0.86 ?
Positive_regulation (increase) of GFR
1) Confidence 0.56 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.38 Pain Relevance 0
HOI caused significant decrements of MAP, PRA, aldosterone, and catecholamines, and increased ANP, GFR, from 94 +/- 5 to 102 +/- 5 ml/min (P < 0.01), ERPF, from 529 +/- 30 to 616 +/- 35 ml/min (P < 0.01), and sodium excretion.
Positive_regulation (increased) of GFR associated with catecholamine
2) Confidence 0.41 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7474676 Disease Relevance 0.36 Pain Relevance 0.40
We used the following effect markers: cystatin C in serum (Dharnidharka et al. 2002) for calculation of glomerular filtration rate (GFR), creatinine clearance as markers of glomerular function, and human complex-forming protein (protein HC, ?
Positive_regulation (calculation) of GFR associated with disorders of creatine metabolism
3) Confidence 0.40 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310929 Disease Relevance 0.34 Pain Relevance 0.03
Several studies regarding cystatin C as diagnostic index of renal function in renal transplant patients using Ccr as a reference GFR have been performed, although the accuracy of serum cystatin C and serum creatinine for evaluating GFR differed between the various studies (28).
Positive_regulation (evaluating) of GFR associated with disorders of creatine metabolism and renal failure
4) Confidence 0.35 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.58 Pain Relevance 0.03
In contrast, the prevalence of 1 vessel disease was increased according to increased GFR.
Positive_regulation (increased) of GFR associated with disease
5) Confidence 0.33 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.55 Pain Relevance 0.10
Smokers in this study had a statistically increased GFR compared to non-smokers which is similar to what has been reported for a large population based study from France [36].
Positive_regulation (increased) of GFR associated with nicotine addiction
6) Confidence 0.27 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 1.04 Pain Relevance 0.04
In contrast, the prevalence of 1 vessel disease was increased according to increased GFR.
Positive_regulation (increased) of GFR associated with disease
7) Confidence 0.24 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.55 Pain Relevance 0.10
Outcomes according to the estimated GFR
Positive_regulation (estimated) of GFR
8) Confidence 0.21 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.22 Pain Relevance 0.08
If the GFR is estimated at less than 30 ml.min?
Positive_regulation (estimated) of GFR
9) Confidence 0.18 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 1.13 Pain Relevance 0.20
CONCLUSIONS: Short-term infusion of low to moderate, non-hypertensive doses of vasopressin induced a post-glomerular renal vasoconstriction with a decrease in RBF and an increase in GFR in post-cardiac surgery patients.
Positive_regulation (increase) of GFR
10) Confidence 0.17 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19572935 Disease Relevance 0 Pain Relevance 0
Healthy Caucasian carriers of the A1166C polymorphism showed 7% lower basal GFR and 17% lower basal renal plasma flow, as well as enhanced increases in GFR following treatment with the AT1R blocker losartan [17].
Positive_regulation (increases) of GFR in plasma
11) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.84 Pain Relevance 0
The mean calculated GFR and overall graft survival were also better in the MMF/TAC group.57
Positive_regulation (calculated) of GFR
12) Confidence 0.09 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.33 Pain Relevance 0.09
The simplified MDRD formula has been found to vary most from measured GFR in individuals with normal or near normal renal function, i.e. ?
Positive_regulation (measured) of GFR associated with renal disease
13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.51 Pain Relevance 0
It was postulated that the Trp polymorphism may be associated with increased GFR which balances the increased sodium reabsorption [45].
Positive_regulation (increased) of GFR
14) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 0.76 Pain Relevance 0
This study corroborates the increase of GFR in children and adolescents with ADPKD and the superior diagnostic performance of Cys C [57].
Positive_regulation (increase) of GFR in superior associated with autosomal dominant polycystic kidney
15) Confidence 0.05 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.83 Pain Relevance 0
More importantly, the mean decrease in the estimated GFR (eGFR) over the 52-week period was less in the benazepril/amlodipine group than in the benazepril/HCTZ group (?
Positive_regulation (estimated) of GFR
16) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.35 Pain Relevance 0
When the normal compensatory mechanisms such as NO, bradykinin, adenosine, and prostaglandins are unable to maintain GFR in the setting of decreased RBF, the groundwork for renal ischemia is laid.
Neg (unable) Positive_regulation (maintain) of GFR associated with adenocard, ischemia and bradykinin
17) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.92 Pain Relevance 0.23
Median GFR was not different between the two treatment groups at baseline (agalsidase alfa: 99 ml/min, range 22 to 136, agalsidase beta: 108, range 53 to 154, p?
Positive_regulation (Median) of GFR
18) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.24 Pain Relevance 0
The placebo-to-active-treatment-cross-over group showed an increase in GFR of 9 ml/min (?
Positive_regulation (increase) of GFR
19) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.23 Pain Relevance 0.12

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