INT47742

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 31
Disease Relevance 3.28
Pain Relevance 15.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
brain 1
nervous system 1
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 220 100.00 Very High Very High Very High
noradrenaline 14 100.00 Very High Very High Very High
Serotonin 72 99.98 Very High Very High Very High
cocaine 43 99.98 Very High Very High Very High
antidepressant 263 99.92 Very High Very High Very High
Duloxetine 102 99.92 Very High Very High Very High
monoamine 46 99.82 Very High Very High Very High
lidocaine 2 99.54 Very High Very High Very High
Gabapentin 492 99.12 Very High Very High Very High
sodium channel 2 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 221 99.84 Very High Very High Very High
Respiratory Tract Infection 4 98.84 Very High Very High Very High
Galactorrhea 4 96.56 Very High Very High Very High
Confusion 7 93.12 High High
Depression 197 89.48 High High
Low Back Pain 6 86.88 High High
Nervous System Injury 3 81.12 Quite High
Stress 21 64.84 Quite High
Psychosis 12 62.64 Quite High
Hypersensitivity 3 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possibilities that cocaine interacts with the dopamine transporter in a qualitatively different manner from that of these selective dopamine uptake inhibitors, or that other monoamine systems are involved, are discussed.
transporter Binding (interacts) of associated with dopamine, monoamine and cocaine
1) Confidence 0.42 Published 1999 Journal Behav. Brain Res. Section Abstract Doc Link 10512586 Disease Relevance 0.16 Pain Relevance 0.90
Characteristics of the specific binding of the 5-HT2A serotonin receptor and the serotonin transporter were studied using a radioligand binding technique.
transporter Binding (binding) of
2) Confidence 0.36 Published 2000 Journal Headache Section Body Doc Link 10849027 Disease Relevance 0 Pain Relevance 0
KEY RESULTS: WAY-318068 is a potent and effective inhibitor of the NET with a K(i) of 8.7 nM in a binding assay, and an IC(50) of 6.8 nM in an assay of transporter function, without significant binding to the dopamine transporter.
transporter Binding (binding) of
3) Confidence 0.30 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590604 Disease Relevance 0 Pain Relevance 0
KEY RESULTS: WAY-318068 is a potent and effective inhibitor of the NET with a K(i) of 8.7 nM in a binding assay, and an IC(50) of 6.8 nM in an assay of transporter function, without significant binding to the dopamine transporter.
transporter Binding (binding) of
4) Confidence 0.30 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590604 Disease Relevance 0 Pain Relevance 0
Triadimefon has been shown to inhibit monoamine uptake, bind to the dopamine (DA) transporter, and stimulate dopamine efflux in rat brain tissue, in vitro.
transporter Binding (bind) of in brain associated with dopamine and monoamine
5) Confidence 0.26 Published 2006 Journal Toxicology Section Abstract Doc Link 16246478 Disease Relevance 0 Pain Relevance 0.30
Fentanyl decreases beta-CIT binding to the dopamine transporter.
transporter Binding (binding) of associated with dopamine
6) Confidence 0.25 Published 1998 Journal Synapse Section Title Doc Link 9661259 Disease Relevance 0.08 Pain Relevance 0.58
We report here an effect of fentanyl on striatal [123I]beta-CIT binding to the DA transporter in a patient and in rats.
transporter Binding (binding) of associated with dopamine
7) Confidence 0.25 Published 1998 Journal Synapse Section Abstract Doc Link 9661259 Disease Relevance 0.09 Pain Relevance 0.57
IPT: a novel iodinated ligand for the CNS dopamine transporter.
transporter Binding (ligand) of associated with dopamine
8) Confidence 0.21 Published 1995 Journal Synapse Section Title Doc Link 7482291 Disease Relevance 0.08 Pain Relevance 0.46
Nefazodone also binds to the norepinephrine transporter in vitro and in acute ex vivo studies.
transporter Binding (binds) of
9) Confidence 0.17 Published 1995 Journal Life Sci. Section Abstract Doc Link 7475971 Disease Relevance 0.09 Pain Relevance 0.51
The sodium channel blocker, dimethocaine which has a relatively high affinity for the dopamine transporter fully generalized to the cocaine stimulus in both groups of rats, while procaine which has a low affinity for the dopamine transporters only partially generalized to the cocaine-training stimulus in both groups of rats 5.
transporter Binding (affinity) of associated with dopamine, sodium channel and cocaine
10) Confidence 0.15 Published 2001 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 11371002 Disease Relevance 0 Pain Relevance 1.02
Finally, lidocaine, which has negligible affinity for the dopamine transporter, did not generalize to the cocaine-training stimulus in either group of rats.
transporter Binding (affinity) of associated with dopamine, lidocaine and cocaine
11) Confidence 0.15 Published 2001 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 11371002 Disease Relevance 0 Pain Relevance 0.92
Most compounds in this series possessed a very low activity at the DA transporter (DAT) but a good to excellent affinity for the 5-HT transporter (SERT).
transporter Binding (affinity) of associated with dopamine
12) Confidence 0.09 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 11960503 Disease Relevance 0 Pain Relevance 0.34
Synthesis and evaluation of vesamicol analog (-)-O-[11C]methylvesamicol as a PET ligand for vesicular acetylcholine transporter.

(-)-O-Methylvesamicol ((-)-OMV) exhibited in vitro a high affinity for vesicular acetylcholine transporter (VAChT) (Ki, 6.7 nM) and a relatively low affinity for sigmal receptor (Ki, 33.7 nM).

transporter Binding (affinity) of
13) Confidence 0.07 Published 2006 Journal Ann Nucl Med Section Title Doc Link 16922470 Disease Relevance 0 Pain Relevance 0.12
DA transporter (DAT) binding was defined with 50pM [125I]RTI-55 (Perkin Elmer) in the presence of 1 ┬ÁM fluoxetine (Sigma) in buffer A (Tris 50 mM, pH 7.4 ; NaCl 120 mM ; KCl 5 mM ; BSA 0.25%) .
transporter Binding (binding) of associated with respiratory tract infection and fluoxetine
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.16 Pain Relevance 0.29
Potency reflects the concentration of the antidepressant inhibiting 50% of uptake or binding to the transporter, depending on the technique used.
transporter Binding (binding) of associated with antidepressant and potency
15) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.09 Pain Relevance 0.54
The selectivity of an antidepressant is the ratio of the potency values for NE and 5-HT reuptake inhibition (or inhibition of binding to the transporter).
transporter Binding (binding) of associated with antidepressant and potency
16) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.05 Pain Relevance 0.37
To block the binding of NE to its transporter, duloxetine is about 27 times more potent than milnacipran.
transporter Binding (binding) of associated with duloxetine
17) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.08 Pain Relevance 0.45
Like many of the tricyclics, venlafaxine binds to the transporter protein of both norepinephrine and serotonin.
transporter Binding (binds) of associated with serotonin
18) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899788 Disease Relevance 0.05 Pain Relevance 0.88
Venlafaxine has a much greater affinity for the 5-HT transporter than for the NE transporter.
transporter Binding (affinity) of
19) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.31 Pain Relevance 0.58
Thus from Table 1 it can be seen that duloxetine is 154 times more potent than milnacipran at blocking the binding of 5-HT to the transporter (ie, 154 times more milnacipran is required to obtain the same effect).
transporter Binding (binding) of associated with duloxetine
20) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.09 Pain Relevance 0.51

General Comments

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