INT47743

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.23
Pain Relevance 12.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
brain 2
dorsal 1
5-HT neurons 1
vessels 1
pulmonary artery 1
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 267 100.00 Very High Very High Very High
Dopamine 251 100.00 Very High Very High Very High
Serotonin 99 100.00 Very High Very High Very High
fluoxetine 111 99.98 Very High Very High Very High
Morphine 7 99.04 Very High Very High Very High
sSRI 64 98.92 Very High Very High Very High
withdrawal 9 98.68 Very High Very High Very High
depression 233 98.36 Very High Very High Very High
Hippocampus 45 98.28 Very High Very High Very High
positron emission tomography 2 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 255 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1 100.00 Very High Very High Very High
Targeted Disruption 58 99.96 Very High Very High Very High
Hypertrophy 36 98.74 Very High Very High Very High
Opiate Addiction 5 98.68 Very High Very High Very High
Hypertension 18 98.20 Very High Very High Very High
Disease 14 98.08 Very High Very High Very High
Pulmonary Hypertension 150 97.62 Very High Very High Very High
Urological Neuroanatomy 14 93.72 High High
Shock 6 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Chronic blockade of serotonin transporter promotes restoration of the sensitivity of pulmonary vessels to vasoconstrictive agents in rats with monocrotaline-induced pulmonary hypertension].
Negative_regulation (blockade) of serotonin transporter in vessels associated with hypertension and serotonin
1) Confidence 0.59 Published 2007 Journal Eksp Klin Farmakol Section Title Doc Link 18078038 Disease Relevance 0.18 Pain Relevance 0.34
Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.
Negative_regulation (inhibition) of Serotonin transporter associated with hypertension and serotonin
2) Confidence 0.49 Published 2005 Journal Circulation Section Title Doc Link 15927991 Disease Relevance 0.55 Pain Relevance 0.22
To further investigate the ability of nefazodone to modify serotonergic transmission, the ability of systemically administered nefazodone to inhibit the serotonin transporter was assessed by investigating the ability of nefazodone to prevent p-chloroamphetamine- (PCA) induced depletions of cortical 5-HT concentrations.
Negative_regulation (inhibit) of serotonin transporter associated with serotonin
3) Confidence 0.46 Published 1995 Journal Life Sci. Section Abstract Doc Link 7475971 Disease Relevance 0.08 Pain Relevance 0.53
The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies.
Negative_regulation (inhibits) of serotonin transporter associated with antidepressant and serotonin
4) Confidence 0.46 Published 1995 Journal Life Sci. Section Title Doc Link 7475971 Disease Relevance 0.09 Pain Relevance 0.53
[Chronic administration of serotonin transporter inhibitor (fluoxetine) decreases monocrotaline-induced pulmonary hypertension in rats].
Negative_regulation (inhibitor) of serotonin transporter associated with hypertension, serotonin and fluoxetine
5) Confidence 0.43 Published 2007 Journal Eksp Klin Farmakol Section Title Doc Link 18074800 Disease Relevance 0.28 Pain Relevance 0.42
Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus.
Negative_regulation (reduces) of serotonin transporter in dorsal associated with raphe, serotonin and fluoxetine
6) Confidence 0.43 Published 1996 Journal Neuropsychopharmacology Section Title Doc Link 8914125 Disease Relevance 0.19 Pain Relevance 0.99
Imipramine binding could be inhibited by potent non-tricyclic inhibitors of the serotonin transporter such as paroxetine and fluoxetine but also by the tricyclic antidepressant drugs clomipramine and desipramine.
Negative_regulation (inhibitors) of serotonin transporter associated with desipramine, tricyclic antidepressant, serotonin and fluoxetine
7) Confidence 0.38 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7478203 Disease Relevance 0 Pain Relevance 0.36
Fluoxetine reduced serotonin transporter mRNA briefly, but this was not sustained after 21 days of treatment.
Negative_regulation (reduced) of serotonin transporter associated with serotonin and fluoxetine
8) Confidence 0.37 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8914125 Disease Relevance 0.15 Pain Relevance 1.15
Previous investigations had shown that inhibitor of serotonin reuptake transporter (SERT) could attenuate morphine withdrawal syndrome in adult animals.
Negative_regulation (inhibitor) of serotonin reuptake transporter associated with withdrawal, serotonin and morphine
9) Confidence 0.36 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15814088 Disease Relevance 0.31 Pain Relevance 0.95
For example, the following five genes were significantly associated with major depressive disorder in meta-analyses of polymorphisms that had been investigated in at least three studies [30]: apolipoprotein E (APOE), guanine nucleotide-binding protein (GNB3), methylenetetrahydrofolate reductase (MTHFR), dopamine transporter (SLC6A3), and serotonin transporter (SLC6A4).
Negative_regulation (depressive) of serotonin transporter associated with dopamine, depression, serotonin and disorder of lipid metabolism
10) Confidence 0.36 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2977055 Disease Relevance 0.87 Pain Relevance 0.44
In contrast, chronic fluoxetine markedly decreased 5-HTT levels in all regions.
Negative_regulation (decreased) of 5-HTT associated with fluoxetine
11) Confidence 0.22 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18496518 Disease Relevance 0 Pain Relevance 0.82
This downregulation of 5-HTT by fluoxetine and its enhancement by Org 34850 can explain our recent observation that GR antagonists augment the SSRI-induced increase in extracellular 5-HT.
Negative_regulation (downregulation) of 5-HTT associated with antagonist, ssri and fluoxetine
12) Confidence 0.22 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18496518 Disease Relevance 0 Pain Relevance 1.03
Furthermore, a selective serotonin reuptake inhibitor, sertraline, protects against MCT-induced PAH by decreasing pulmonary artery pressure, RV hypertrophy index, and pulmonary artery remodeling, probably related to a reduction in serotonin transporter mRNA [23].
Negative_regulation (reduction) of serotonin transporter in pulmonary artery associated with hypertrophy, pulmonary hypertension, serotonin and ssri
13) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.14 Pain Relevance 0.64
Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease.
Negative_regulation (inhibitor) of serotonin transporter associated with disease and serotonin
14) Confidence 0.10 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14501158 Disease Relevance 0.16 Pain Relevance 0.25
A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized.
Negative_regulation (inhibitor) of serotonin transporter associated with serotonin
15) Confidence 0.10 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501158 Disease Relevance 0.07 Pain Relevance 0.19
The dominant influence of serotonin on pursuit of BSR appears to be opposite to the changes in reward pursuit reported here [58], [59], and thus, blockade of the serotonin transporter likely restricted the magnitude of these effects.
Negative_regulation (blockade) of serotonin transporter associated with serotonin
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994896 Disease Relevance 0 Pain Relevance 0.76
There is also neuroimaging evidence that these patients suffer from a marked loss of serotonin transporters (5-HTT) in several brain regions [19], although a recent post-mortem report showed that the reductions in 5-HTT might not be as widespread as suggested by the positron emission tomography data [20].
Negative_regulation (loss) of 5-HTT in brain associated with positron emission tomography and serotonin
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.34 Pain Relevance 0.33
There is also neuroimaging evidence that these patients suffer from a marked loss of serotonin transporters (5-HTT) in several brain regions [19], although a recent post-mortem report showed that the reductions in 5-HTT might not be as widespread as suggested by the positron emission tomography data [20].
Negative_regulation (reductions) of 5-HTT in brain associated with positron emission tomography and serotonin
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.31 Pain Relevance 0.32
Like all SSRI, it exerts its antidepressant effects mainly through inhibition of the serotonin transporter (5-HTT).
Negative_regulation (inhibition) of serotonin transporter associated with antidepressant, serotonin and ssri
19) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515903 Disease Relevance 0.21 Pain Relevance 0.41
Developmental loss of 5-HTT produces altered behaviour in models of depression associated with reduced 5-HT neurons and decreased firing rate in the dorsal raphae nucleus [169].
Negative_regulation (loss) of 5-HTT in 5-HT neurons associated with depression
20) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.45 Pain Relevance 0.51

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