INT47744

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 5.52
Pain Relevance 9.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
brain 3
retina 1
tooth germ 1
cerebral cortex 1
serotonergic neurons 1
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 124 100.00 Very High Very High Very High
nMDA receptor 12 100.00 Very High Very High Very High
5HT 3 100.00 Very High Very High Very High
Migraine 3 100.00 Very High Very High Very High
sodium channel 2 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
antidepressant 101 99.56 Very High Very High Very High
antagonist 23 99.50 Very High Very High Very High
fluoxetine 50 99.28 Very High Very High Very High
cerebral cortex 4 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine With Aura 5 100.00 Very High Very High Very High
Macrocephaly 1 99.44 Very High Very High Very High
Death 13 99.24 Very High Very High Very High
Schizophrenia 9 98.74 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 164 98.36 Very High Very High Very High
Depression 162 98.16 Very High Very High Very High
Affective Disorder 11 97.80 Very High Very High Very High
Heart Rate Under Development 1 97.12 Very High Very High Very High
Drug Induced Neurotoxicity 2 96.56 Very High Very High Very High
Increased Venous Pressure Under Development 9 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated antidepressant drug treatment, time of death and frequency of handling do not affect [3H]paroxetine binding in rat cortex.

[3H]Paroxetine binding to the serotonin transporter has been shown to be altered in brain tissue from schizophrenic subjects.

serotonin transporter Binding (binding) of in brain associated with antidepressant, serotonin, schizophrenia and death
1) Confidence 0.48 Published 1997 Journal Psychiatry Res Section Title Doc Link 9481808 Disease Relevance 0.46 Pain Relevance 0.33
Some schizophrenic subjects are treated with antidepressant drugs, some of which bind to the serotonin transporter and their time of death is variable.
serotonin transporter Binding (bind) of associated with antidepressant, serotonin, death and schizophrenia
2) Confidence 0.48 Published 1997 Journal Psychiatry Res Section Abstract Doc Link 9481808 Disease Relevance 0.44 Pain Relevance 0.23
Fluoxetine at the same dose blocked ex vivo binding to the serotonin transporter, but not the norepinephrine transporter, suggesting that the increase of catecholamines was not due to non-selective blockade of norepinephrine uptake.
serotonin transporter Binding (binding) of
3) Confidence 0.48 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 11919662 Disease Relevance 0 Pain Relevance 0
In addition, [3H]milnacipran might also bind to other sites, serotonin transporter localized on non-serotonergic neurons or serotonergic neurons insensitive to 5,7-DHT neurotoxicity.
serotonin transporter Spec (might) Binding (bind) of in serotonergic neurons associated with drug induced neurotoxicity and serotonin
4) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 7704599 Disease Relevance 0.10 Pain Relevance 0.51
These results show that [3H]milnacipran mainly binds to the serotonin transporter and does not recognize the catecholamine transporters under the conditions used.
serotonin transporter Binding (binds) of associated with catecholamine and serotonin
5) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 7704599 Disease Relevance 0 Pain Relevance 0.56
Odds ratios (ORs) of upper gastrointestinal bleeding for antidepressant drugs grouped by affinity for the serotonin transporter, selectivity and dose, with adjustment for potential confounders were estimated.
serotonin transporter Binding (affinity) of in upper
6) Confidence 0.46 Published 2008 Journal Drug Saf Section Body Doc Link 18217791 Disease Relevance 0 Pain Relevance 0
Of interest, a recent study found an epistatic interaction of Slc6a4 and Pten for macrocephaly in mice [39].
Slc6a4 Binding (interaction) of associated with macrocephaly
7) Confidence 0.45 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.32 Pain Relevance 0.21
Binding to the serotonin transporter was not identifiable.
serotonin transporter Binding (Binding) of associated with serotonin
8) Confidence 0.45 Published 1998 Journal Nucl. Med. Biol. Section Abstract Doc Link 9804041 Disease Relevance 0 Pain Relevance 1.21
To replicate a reported association between migraine with aura (MA) and a promoter polymorphism in the serotonin transporter gene (SLC6A4), we performed a case-control study in a large German sample comprising 472 patients with MA and 506 controls.
SLC6A4 Binding (association) of associated with migraine with aura, migraine and serotonin
9) Confidence 0.44 Published 2006 Journal Neurology Section Abstract Doc Link 17101915 Disease Relevance 0.37 Pain Relevance 0.26
Finally, a recent meta-analysis was conducted of the interaction between the serotonin transporter gene (5-HTTLPR) and stressful life events on depression using a total sample of 14,250 participants divided into cases and controls.
serotonin transporter Binding (interaction) of associated with depression and serotonin
10) Confidence 0.41 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2977055 Disease Relevance 0.56 Pain Relevance 0.63
Characterization of serotonin transporter in goldfish retina by the binding of [3H]paroxetine and the uptake of [3H]serotonin: modulation by light.
serotonin transporter Binding (Characterization) of in retina associated with serotonin
11) Confidence 0.36 Published 1994 Journal J. Neurochem. Section Title Doc Link 8294915 Disease Relevance 0 Pain Relevance 0.34
Ibogaine and its metabolite noribogaine have low microM affinities for kappa and mu opioid receptors, NMDA receptors, 5HT-3 receptors, sigma-2 sites, sodium channels and the serotonin transporter. 18-MC has low microM affinities at all three opioid receptors and at 5HT-3 receptors but much lower or no affinities for NMDA and sigma-2 receptors, sodium channels, and the 5HT transporter.
serotonin transporter Binding (affinities) of associated with nmda receptor, sodium channel, 5ht, mu opioid receptor, opioid receptor and serotonin
12) Confidence 0.32 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10911925 Disease Relevance 0.31 Pain Relevance 1.02
In tooth development, serotonin appears to stimulate odontogenesis by interacting with different serotonin receptors13 expressed in the epithelium and dental mesenchyme during odontogenesis9 and through sites of 5-HT uptake present in the tooth germ during development.14 The administration of fluoxetine in pregnant rats can alter the levels of available serotonin, making it possible to study its influence on tooth development, which, in turn, results from important epithelial-mesenchymal interactions3.
serotonin receptors13 Binding (interacting) of in tooth germ associated with serotonin and fluoxetine
13) Confidence 0.29 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2815284 Disease Relevance 0 Pain Relevance 0.63
Data of the 5-HTT binding were analysed by means of non-linear least squares regression using a commercial program GraphPad PRISM™ (GraphPad, San Diego, CA, USA) and obtained parameters compared with t-tests.
5-HTT Spec (analysed) Binding (binding) of
14) Confidence 0.29 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0 Pain Relevance 0.11
Previous studies have shown that nefazodone is a potent antagonist of 5-HT2A receptors and binds to the serotonin transporter in vitro and in vivo.
serotonin transporter Binding (binds) of associated with antagonist and serotonin
15) Confidence 0.28 Published 1995 Journal Life Sci. Section Abstract Doc Link 7475971 Disease Relevance 0.09 Pain Relevance 0.52
Estrogen increases serotonin transporter (SERT) mRNA and binding sites in female rat brain.
serotonin transporter Binding (binding) of in brain associated with serotonin
16) Confidence 0.26 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9878762 Disease Relevance 0 Pain Relevance 0.24
Also, 5-HT transporter (5-HTT) levels were measured in the same brain regions by radioligand binding.
5-HTT Binding (binding) of in brain
17) Confidence 0.22 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.46 Pain Relevance 0.35
Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries.
serotonin transporter Binding (interactions) of associated with serotonin
18) Confidence 0.18 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15659538 Disease Relevance 0.44 Pain Relevance 0.30
In a study of a group of elderly athletes we observed an unexpected association between serum cholesterol levels and the HTTLPR insertion/deletion polymorphism of the promoter region of the serotonin transporter gene (HTT, SLC6A4).
SLC6A4 Binding (association) of associated with serotonin
19) Confidence 0.11 Published 1999 Journal Mol. Genet. Metab. Section Abstract Doc Link 10381332 Disease Relevance 0.25 Pain Relevance 0.09
Our most intriguing result involved three SNPs in the TPH1 gene and one SNP in the SLC6A4 gene, which show significant single-locus association when response to fluoxetine is compared to nonresponse (P=0.02-0.04).
SLC6A4 Binding (association) of associated with fluoxetine
20) Confidence 0.07 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15052272 Disease Relevance 0.07 Pain Relevance 0.49

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