INT47758

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
neuronal 2
hippocampus 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 97.52 Very High Very High Very High
long-term potentiation 3 95.52 Very High Very High Very High
nMDA receptor antagonist 1 93.64 High High
Hippocampus 2 93.56 High High
Opioid 1 92.44 High High
addiction 3 81.68 Quite High
nMDA receptor 1 35.36 Quite Low
TRP channel 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 62 95.88 Very High Very High Very High
Cognitive Disorder 4 95.64 Very High Very High Very High
Targeted Disruption 2 75.08 Quite High
Convulsion 1 73.80 Quite High
Toxicity 12 50.80 Quite High
Alzheimer's Dementia 23 50.00 Quite Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Amyloid Plaque 9 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low
Dementia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that at short time periods (1-6 h) after injections of NMDA or sin-1 molsidomine, there is an increase in the levels of the mRNA encoding the alpha subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKII alpha), consistent with a report of elevated CaMKII alpha mRNA in postsynaptic neurons in the CA1 region of the hippocampus following LTP induction [54].
Positive_regulation (increase) of Transcription (levels) of Ca2 in hippocampus associated with long-term potentiation and hippocampus
1) Confidence 0.49 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476022 Disease Relevance 0 Pain Relevance 0.28
More indirect evidence that supports this idea is the enhancement of Ca2+ and K+ ion channel activity that has been observed in rodent cortical neuronal cultures upon application of soluble forms of A?
Positive_regulation (enhancement) of Transcription (activity) of Ca2 in neuronal
2) Confidence 0.15 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.54 Pain Relevance 0.05
Addition of Ca2+ after activation by 4?
Positive_regulation (activation) of Transcription (Addition) of Ca2
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.09

General Comments

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