INT4776

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 82
Total Number 84
Disease Relevance 16.89
Pain Relevance 45.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
nerve 10
muscle 5
spinal cord 4
sensory nerve 4
lung 4
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 503 100.00 Very High Very High Very High
qutenza 257 100.00 Very High Very High Very High
Calcitonin gene-related peptide 120 100.00 Very High Very High Very High
Neuropeptide 92 100.00 Very High Very High Very High
Enkephalin 88 100.00 Very High Very High Very High
Serotonin 22 100.00 Very High Very High Very High
Somatostatin 15 100.00 Very High Very High Very High
Analgesic 8 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
Catecholamine 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 42 100.00 Very High Very High Very High
Pituitary Cancer 2 99.72 Very High Very High Very High
INFLAMMATION 82 99.64 Very High Very High Very High
Neurogenic Inflammation 16 99.28 Very High Very High Very High
Eosinophilia 6 98.72 Very High Very High Very High
Carcinoid 5 98.56 Very High Very High Very High
Rhinitis 8 98.48 Very High Very High Very High
Ganglion Cysts 22 98.12 Very High Very High Very High
Nicotine Addiction 8 97.76 Very High Very High Very High
Pain 43 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that spontaneous phasic contractions of normal sigmoid circular muscle strips were significantly reduced by 90-min incubation with tetrodotoxin (10(-5) M), which blocked neurokinin A release in basal conditions and in response to electrical stimulation.
Localization (release) of neurokinin A in muscle associated with tetrodotoxin
1) Confidence 0.78 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16554357 Disease Relevance 0.26 Pain Relevance 0.18
Immunohistochemical localization of tyrosine hydroxylase, substance P, neuropeptide-Y and leucine-enkephalin in developing human retinal amacrine cells.
Localization (localization) of substance P in amacrine cells associated with neuropeptide, enkephalin and substance p
2) Confidence 0.78 Published 1994 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 7513625 Disease Relevance 0 Pain Relevance 0.64
More recently, both functional and neurochemical evidence have been accumulated that BK evokes release of neuropeptides, including calcitonin gene-related peptide and the tachykinins substance P and neurokinin A, from peripheral terminals of capsaicin-sensitive primary afferents.
Localization (release) of neurokinin A associated with qutenza, neuropeptide, bradykinin, substance p and calcitonin gene-related peptide
3) Confidence 0.78 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8210518 Disease Relevance 0 Pain Relevance 0.55
Immunohistochemical localization of the catecholamine-synthesizing enzymes, substance P and enkephalin in the human fetal sympathetic ganglion.
Localization (localization) of substance P in sympathetic ganglion associated with ganglion cysts, catecholamine, enkephalin and substance p
4) Confidence 0.78 Published 1981 Journal Cell Tissue Res. Section Title Doc Link 6162566 Disease Relevance 0.10 Pain Relevance 0.71
More recent studies indicate that SCS releases substance P serotonin, noradrenaline and GABA in the dorsal horns; activation of the GABAB receptor may be linked to a decrease in the release of glutamate and other excitatory amino acids, resulting in a decrease of neuropathic pain.
Localization (releases) of substance P in dorsal horns associated with neuropathic pain, gaba, glutamate, noradrenaline, serotonin, spinal-cord stimulation, substance p and excitatory amino acid
5) Confidence 0.78 Published 2009 Journal Masui Section Abstract Doc Link 19928506 Disease Relevance 1.02 Pain Relevance 1.30
In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis.
Localization (secretion) of neurokinin A in nasal associated with rhinitis, qutenza, neuropeptide, calcitonin gene-related peptide and substance p
6) Confidence 0.78 Published 1999 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 10547475 Disease Relevance 0.40 Pain Relevance 0.80
Substance P and neurokinin A are tachykinins that are co-localized with calcitonin gene-related peptide (CGRP) in a unique subpopulation of cardiac afferent nerve fibers.
Localization (co-localized) of Substance P in nerve associated with calcitonin gene-related peptide and substance p
7) Confidence 0.73 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11202607 Disease Relevance 0.24 Pain Relevance 0.27
The structurally related neuropeptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), which belong to a family of molecules termed tachykinins and are widely distributed in the central and peripheral nervous systems, influence the function of many tissues.
Localization (distributed) of neurokinin A in peripheral nervous systems associated with neuropeptide and substance p
8) Confidence 0.73 Published 1999 Journal Curr. Med. Chem. Section Abstract Doc Link 10101218 Disease Relevance 0.59 Pain Relevance 0.47
In a previous study, Pinto et al. showed in a human total mRNA master panel (BD Biosciences Clontech) that TAC1 and TAC3 mRNAs were undetectable in the lung, but they observed a low expression of these transcripts in samples of human bronchi obtained from patients who had undergone lobectomy or pneumectomy for lung carcinoma, a high expression being observed in pulmonary arteries [48].
Localization (undetectable) of TAC1 in lung associated with lung cancer
9) Confidence 0.68 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.09 Pain Relevance 0.11
Stimulation of Cl secretion by neurokinin A and neurokinin B in canine tracheal epithelium.
Localization (secretion) of neurokinin A in epithelium associated with neuropeptide
10) Confidence 0.68 Published 1988 Journal Am. Rev. Respir. Dis. Section Title Doc Link 2833141 Disease Relevance 0 Pain Relevance 0.10
To examine if these responses are mediated by different neurokinin receptors, we studied the mechanical response and the release of [3H]acetylcholine from antral muscle strips in response to SP, substance P methylester (SPME), neurokinin A (NKA), neurokinin B (NKB), and several non-mammalian tachykinins.
Localization (release) of neurokinin A in muscle associated with substance p
11) Confidence 0.68 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2462362 Disease Relevance 0 Pain Relevance 0.36
Further study with selective tachykinin NK(1) and NK(2) agonists demonstrated that only the septide-insensitive tachykinin NK(1) receptor releases NO.
Neg (NO) Localization (releases) of tachykinin associated with agonist
12) Confidence 0.68 Published 2001 Journal Am. J. Med. Section Abstract Doc Link 11749919 Disease Relevance 0.34 Pain Relevance 0.41
Opioid and tachykinin neuropeptides in prolactin-secreting human pituitary adenomas.
Localization (secreting) of tachykinin in pituitary associated with pituitary cancer, neuropeptide and opioid
13) Confidence 0.68 Published 1995 Journal Peptides Section Title Doc Link 8532594 Disease Relevance 0.26 Pain Relevance 1.09
Thus, low-dose intrathecal clonidine releases the tachykinins substance P and neurokinin A in the spinal cord.
Localization (releases) of neurokinin A in spinal cord associated with spinal cord, substance p, clonidine and intrathecal
14) Confidence 0.68 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7686104 Disease Relevance 0 Pain Relevance 0.54
Thus, low-dose intrathecal clonidine releases the tachykinins substance P and neurokinin A in the spinal cord.
Localization (releases) of substance P in spinal cord associated with spinal cord, substance p, clonidine and intrathecal
15) Confidence 0.68 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7686104 Disease Relevance 0 Pain Relevance 0.54
The regulatory roles of spinal adenosine in the CAP-evoked substance P release and the possible involvement of adenosine A2 receptors were analyzed by analyzing the changes in cardiovascular responses to i.a. and i.v. injection of CAP after various pretreatments with adenosine agonists and antagonists, administered subcutaneously or intrathecally.
Localization (release) of substance P in spinal associated with adenocard, qutenza, antagonist, agonist and substance p
16) Confidence 0.68 Published 1993 Journal Gen. Pharmacol. Section Abstract Doc Link 7693543 Disease Relevance 0 Pain Relevance 1.13
We aimed to assess whether calcitonin gene-related peptide (CGRP) can modulate the release of tachykinins which are the main nonadrenergic noncholinergic (NANC) excitatory transmitters to the circular muscle of the guinea-pig proximal colon.
Localization (release) of tachykinin in proximal associated with calcitonin gene-related peptide
17) Confidence 0.68 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9226396 Disease Relevance 0 Pain Relevance 0.21
We have studied the effects of capsaicin (CAP), which releases tachykinins (TK) from the sensory nerves, on eosinophil (EOS) recruitment in the airway in guinea pigs in vivo.
Localization (releases) of tachykinin in eosinophil associated with qutenza
18) Confidence 0.68 Published 1993 Journal Arerugi Section Abstract Doc Link 8498895 Disease Relevance 0.16 Pain Relevance 0.66
We conclude that CAP-induced tachykinin release is capable of causing striking eosinophilia in the lung in vivo.
Localization (release) of tachykinin in lung associated with qutenza and eosinophilia
19) Confidence 0.68 Published 1993 Journal Arerugi Section Abstract Doc Link 8498895 Disease Relevance 0.43 Pain Relevance 0.88
Meanwhile, a broad range of stimuli including capsaicin, bradykinin, hyperosmolar saline, tobacco smoke, allergens, ozone, inflammatory mediators and cold dry air have been shown to activate sensory nerve fibres to release neuropeptides such as the tachykinins substance P (SP) and neurokinin A (NKA) to mediate neurogenic inflammation.
Localization (release) of neurokinin A in sensory nerve associated with nicotine addiction, qutenza, bradykinin, inflammatory mediators, inflammation, neuropeptide, neurogenic inflammation and substance p
20) Confidence 0.68 Published 2006 Journal Pneumologie Section Abstract Doc Link 16463247 Disease Relevance 0.78 Pain Relevance 0.47

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