INT47764

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Context Info
Confidence 0.48
First Reported 1993
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 106
Total Number 111
Disease Relevance 22.62
Pain Relevance 31.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
hippocampus 14
adrenal medulla 7
astrocytes 4
cortex 4
endothelial cells 3
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 34 99.98 Very High Very High Very High
Morphine 51 99.84 Very High Very High Very High
Nicotine 36 99.78 Very High Very High Very High
Opioid 64 99.76 Very High Very High Very High
Enkephalin 72 99.72 Very High Very High Very High
mu opioid receptor 24 99.58 Very High Very High Very High
tolerance 20 99.56 Very High Very High Very High
withdrawal 74 99.50 Very High Very High Very High
Hippocampus 126 99.40 Very High Very High Very High
Nerve growth factor 5 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 6 99.92 Very High Very High Very High
Rheumatoid Arthritis 27 99.78 Very High Very High Very High
Convulsion 84 99.58 Very High Very High Very High
Neuroblastoma 52 99.52 Very High Very High Very High
Cancer 111 98.80 Very High Very High Very High
Stress 65 98.44 Very High Very High Very High
Benign Prostatic Hypertrophy 8 98.08 Very High Very High Very High
INFLAMMATION 222 98.04 Very High Very High Very High
Apoptosis 206 97.56 Very High Very High Very High
Primary Sclerosing Cholangitis 49 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rat hippocampus, jun, c-fos, and fos-related antigen immunoreactivity, AP-1 DNA binding, and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP-1 transcription factors are correlated with the expression of the opioid peptide genes.
AP-1 Binding (binding) of in hippocampus associated with hippocampus and opioid
1) Confidence 0.48 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0 Pain Relevance 0.38
The present studies demonstrate, for the first time, that the binding of activator protein-1 (AP-1)-DNA in rat uterus and the estrogen-sensitive areas of the hypothalamus, as measured by electrophoretic mobility shift assay, is increased 2 h after intraperitoneal injection of [D-Met(2),Pro(5)]enkephalinamide.
AP-1 Binding (binding) of in uterus
2) Confidence 0.48 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10794814 Disease Relevance 0 Pain Relevance 0.33
The present studies demonstrate, for the first time, that the binding of activator protein-1 (AP-1)-DNA in rat uterus and the estrogen-sensitive areas of the hypothalamus, as measured by electrophoretic mobility shift assay, is increased 2 h after intraperitoneal injection of [D-Met(2),Pro(5)]enkephalinamide.
activator protein-1 Binding (binding) of in uterus
3) Confidence 0.48 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10794814 Disease Relevance 0 Pain Relevance 0.33
To evaluate the molecular mechanisms that mediate the effect of learning on morphine tolerance in rats, we examined striatal c-Fos, and c-Jun protein expression, and AP-1 DNA binding.
AP-1 Spec (examined) Binding (binding) of associated with tolerance and morphine
4) Confidence 0.48 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.01
Furthermore, AP-1 DNA binding in P7 hippocampal nuclear extract was unaffected by antibodies against fos-related antigens, in contrast to hippocampal extracts from the older rats examined.
AP-1 Binding (binding) of
5) Confidence 0.47 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.15 Pain Relevance 0.56
These data indicate that repeated activation of D1 receptors increases both the expression of a 35 kDa FRA and AP-1 binding, events which may mediate the large increases in DYN expression in the DA denervated striatum.
AP-1 Binding (binding) of in striatum associated with dopamine and dynorphin
6) Confidence 0.41 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.52
Maximum binding of AP-1, NF-kappa B and Oct was found at 0.5, 1 and 2 h after CFA injection, respectively.
AP-1 Binding (binding) of associated with freund adjuvant
7) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.32 Pain Relevance 0.70
One and one-half hours after kainate administration, fos-related antigen and jun immunoreactivity and AP-1 DNA binding were induced; maximal elevation was observed after 4.5 h.
AP-1 Binding (binding) of
8) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.07 Pain Relevance 0.47
Opioid peptide gene expression, fos-related antigen and jun immunoreactivity, and AP-1 DNA binding all reflected similar reductions after anticonvulsant treatment.
AP-1 Binding (binding) of associated with anticonvulsant and opioid
9) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.09 Pain Relevance 0.61
Therefore, expression and DNA binding activity of the AP-1 transcription factors are correlated with opioid peptide gene expression in the rat hippocampus.
AP-1 Binding (binding) of in hippocampus associated with hippocampus and opioid
10) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.09 Pain Relevance 0.61
One and one-half hours after kainate administration, fos-related antigen and jun immunoreactivity and AP-1 DNA binding were induced; maximal elevation was observed after 4.5 h.
jun Binding (binding) of
11) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.07 Pain Relevance 0.48
In the rat hippocampus, jun, c-fos, and fos-related antigen immunoreactivity, AP-1 DNA binding, and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP-1 transcription factors are correlated with the expression of the opioid peptide genes.
AP-1 Binding (binding) of in hippocampus associated with hippocampus and opioid
12) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.06 Pain Relevance 0.44
Opioid peptide gene expression, fos-related antigen and jun immunoreactivity, and AP-1 DNA binding all reflected similar reductions after anticonvulsant treatment.
jun Binding (binding) of associated with anticonvulsant and opioid
13) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.09 Pain Relevance 0.61
Therefore, expression and DNA binding activity of the AP-1 transcription factors are correlated with opioid peptide gene expression in the rat hippocampus.
AP-1 Binding (activity) of in hippocampus associated with hippocampus and opioid
14) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0.09 Pain Relevance 0.60
Striatal c-Fos protein levels and AP-1 DNA binding activity were increased in rats receiving paired morphine compared with rats that did not receive morphine but not in rats receiving morphine without the CS.
AP-1 Binding (binding) of associated with morphine
15) Confidence 0.36 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.11
Pre-drug cues modulate morphine tolerance, striatal c-Fos, and AP-1 DNA binding.
AP-1 Binding (binding) of associated with tolerance and morphine
16) Confidence 0.36 Published 1998 Journal Neuroreport Section Title Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.08
Striatal c-Fos protein levels and AP-1 DNA binding activity were increased in rats receiving paired morphine compared with rats that did not receive morphine but not in rats receiving morphine without the CS.
AP-1 Binding (activity) of associated with morphine
17) Confidence 0.36 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.12
Gel shift assay showed that the basal level of AP-1 DNA binding activity was significantly higher than that of control rat hippocampus.
AP-1 Binding (activity) of in hippocampus associated with hippocampus
18) Confidence 0.36 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.46 Pain Relevance 0.17
The activator protein-1 (AP-1) DNA binding activity and its components in the hippocampus of such rats were examined by Gel shift, Super-shift and Western blot assay.
activator protein-1 Binding (activity) of in hippocampus associated with hippocampus
19) Confidence 0.36 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.43 Pain Relevance 0.16
Gel shift assay showed that the basal level of AP-1 DNA binding activity was significantly higher than that of control rat hippocampus.
AP-1 Binding (binding) of in hippocampus associated with hippocampus
20) Confidence 0.36 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.46 Pain Relevance 0.17

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