INT47765

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 5.05
Pain Relevance 6.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
adrenal medulla 8
hippocampus 4
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 10 100.00 Very High Very High Very High
Nicotine 20 99.98 Very High Very High Very High
Enkephalin 30 99.90 Very High Very High Very High
Hippocampus 39 99.40 Very High Very High Very High
Inflammation 37 98.04 Very High Very High Very High
Spinal cord 2 96.04 Very High Very High Very High
Endogenous opioid 1 95.84 Very High Very High Very High
depression 4 93.04 High High
opiate 2 91.80 High High
metalloproteinase 2 89.92 High High
Disease Link Frequency Relevance Heat
Convulsion 30 99.58 Very High Very High Very High
INFLAMMATION 34 98.04 Very High Very High Very High
Depression 4 93.04 High High
Esophageal Cancer 1 86.88 High High
Primary Sclerosing Cholangitis 3 85.96 High High
Experimental Arthritis 1 85.04 High High
Hypersensitivity 1 82.28 Quite High
Peptic Ulcer 1 80.56 Quite High
Disease 39 78.32 Quite High
Heart Disease 1 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gel shift assay showed that the basal level of AP-1 DNA binding activity was significantly higher than that of control rat hippocampus.
Negative_regulation (level) of AP-1 Binding (activity) of in hippocampus associated with hippocampus
1) Confidence 0.43 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.46 Pain Relevance 0.17
When secondary seizure stimulations were given to seizure-sensitive rats, the AP-1 DNA binding activity was attenuated and the components of AP-1 proteins changed transiently.
Negative_regulation (attenuated) of AP-1 Binding (binding) of associated with convulsion
2) Confidence 0.43 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.16
Gel shift assay showed that the basal level of AP-1 DNA binding activity was significantly higher than that of control rat hippocampus.
Negative_regulation (level) of AP-1 Binding (binding) of in hippocampus associated with hippocampus
3) Confidence 0.43 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.46 Pain Relevance 0.17
When secondary seizure stimulations were given to seizure-sensitive rats, the AP-1 DNA binding activity was attenuated and the components of AP-1 proteins changed transiently.
Negative_regulation (attenuated) of AP-1 Binding (activity) of associated with convulsion
4) Confidence 0.43 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.16
Furthermore, AP-1 DNA binding in P7 hippocampal nuclear extract was unaffected by antibodies against fos-related antigens, in contrast to hippocampal extracts from the older rats examined.
Neg (unaffected) Negative_regulation (unaffected) of AP-1 Binding (binding) of
5) Confidence 0.42 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.15 Pain Relevance 0.57
Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla.
Negative_regulation (decrease) of AP-1 Binding (binding) of in adrenal medulla associated with medulla, nicotine and enkephalin
6) Confidence 0.39 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.56
Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
Negative_regulation (decreased) of AP-1 Binding (binding) of in adrenal medulla associated with medulla, nicotine and enkephalin
7) Confidence 0.39 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.44
Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla.
Negative_regulation (decrease) of AP-1 Binding (activity) of in adrenal medulla associated with medulla, nicotine and enkephalin
8) Confidence 0.39 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.56
Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15].
Negative_regulation (decreased) of AP-1 Binding (activity) of associated with nicotine
9) Confidence 0.39 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.41
Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
Negative_regulation (decreased) of AP-1 Binding (activity) of in adrenal medulla associated with medulla, nicotine and enkephalin
10) Confidence 0.39 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.44
KA-induced increases of AP-1 and ENKCRE-2 DNA-binding activities were also attenuated by CHX.
Negative_regulation (attenuated) of AP-1 Binding (binding) of
11) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.06
In addition, PDGF-induced DNA binding of activator protein-1 (AP-1) transcription factors was not inhibited by ATRA treatment.
Negative_regulation (inhibited) of activator protein-1 Binding (binding) of
12) Confidence 0.30 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12906928 Disease Relevance 0.33 Pain Relevance 0.17
In addition, cross-competition studies revealed that AP-1 or ENKCRE-2 DNA binding activity was effectively reduced by the 50x unlabeled cross-competitor.
Negative_regulation (reduced) of AP-1 Binding (binding) of
13) Confidence 0.26 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.07
In addition, cross-competition studies revealed that AP-1 or ENKCRE-2 DNA binding activity was effectively reduced by the 50x unlabeled cross-competitor.
Negative_regulation (reduced) of AP-1 Binding (activity) of
14) Confidence 0.26 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.07
Therefore, these data suggest that melatonin has an inhibitory role in KA-induced gene expression, such as proENK and proDYN mRNA expression, and this may be due to a reduction of KA-induced AP-1 or ENKCRE-2 DNA binding activity.
Negative_regulation (reduction) of AP-1 Binding (activity) of
15) Confidence 0.26 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.06
In addition, R-flurbiprofen inhibited DNA binding activity of AP-1, another key regulatory transcription factor in inflammatory processes.
Negative_regulation (inhibited) of AP-1 Binding (activity) of associated with inflammation
16) Confidence 0.25 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.48 Pain Relevance 0.50
In addition, R-flurbiprofen inhibited DNA binding activity of AP-1, another key regulatory transcription factor in inflammatory processes.
Negative_regulation (inhibited) of AP-1 Binding (binding) of associated with inflammation
17) Confidence 0.18 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.48 Pain Relevance 0.50
Gel shift assay and Western blotting revealed that elimination of Fos expression significantly reduced both AP-1 DNA binding activity and PPE expression in the ipsi-MVN after UL.
Negative_regulation (reduced) of AP-1 Binding (binding) of
18) Confidence 0.10 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16547969 Disease Relevance 0.17 Pain Relevance 0.34
Gel shift assay and Western blotting revealed that elimination of Fos expression significantly reduced both AP-1 DNA binding activity and PPE expression in the ipsi-MVN after UL.
Negative_regulation (reduced) of AP-1 Binding (activity) of
19) Confidence 0.10 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16547969 Disease Relevance 0.17 Pain Relevance 0.34
The E(2)-induced increase in the level of Fos proteins and the binding of AP-1 proteins to DNA was inhibited by a single injection of ENK.
Negative_regulation (inhibited) of AP-1 Binding (binding) of
20) Confidence 0.10 Published 2000 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 11074353 Disease Relevance 0 Pain Relevance 0.23

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