INT47766

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 8.78
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
internal 2
photoreceptors 1
lateral 1
medial 1
osteoclast 1
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 12 99.82 Very High Very High Very High
Inflammation 101 99.36 Very High Very High Very High
cytokine 32 98.84 Very High Very High Very High
Glutamate 2 98.72 Very High Very High Very High
Spinal cord 16 98.56 Very High Very High Very High
Hippocampus 47 97.88 Very High Very High Very High
spinal dorsal horn 1 97.40 Very High Very High Very High
Paracetamol 7 97.16 Very High Very High Very High
anesthesia 11 96.16 Very High Very High Very High
rheumatoid arthritis 34 94.96 High High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 160 99.64 Very High Very High Very High
INFLAMMATION 95 99.36 Very High Very High Very High
Hepatotoxicity 6 98.24 Very High Very High Very High
Enterovirus Infection 20 97.88 Very High Very High Very High
Aids-related Complex 74 97.10 Very High Very High Very High
Disease 71 95.04 Very High Very High Very High
Ganglion Cysts 11 95.00 High High
Rheumatoid Arthritis 34 94.96 High High
Hyperalgesia 6 89.32 High High
Necrosis 29 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative abundance of the MHCI-HC, c-Fos and GFAP mRNA transcripts was calculated relative to the mRNA levels of the internal reference gene ?
Transcription (abundance) of c-Fos in internal
1) Confidence 0.69 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
-receptor type 1 involves mitogen-activated protein kinases (MAPKs) and NFkB, which then activate key transcription factors for osteoclast formation, such as c-fos of the activator protein-1 family or NFATc1.
Transcription (transcription) of c-fos in osteoclast
2) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.67 Pain Relevance 0.34
The time-course study showed that c-fos mRNA level was maximal at 10 min and began to decrease 30 min after the Sub P injection in all tissues, and the Sub P-induced increase of the c-fos mRNA level was returned to the control level 1 h after the injection.
Transcription (level) of c-fos mRNA
3) Confidence 0.66 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.35
The time-course study showed that c-fos mRNA level was maximal at 10 min and began to decrease 30 min after the Sub P injection in all tissues, and the Sub P-induced increase of the c-fos mRNA level was returned to the control level 1 h after the injection.
Transcription (level) of c-fos mRNA
4) Confidence 0.66 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.39
Components of the transcriptional complex AP-1 (Fos, Fosb) exhibited gene expression pattern A.
Transcription (transcriptional) of Fos
5) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.04
The expression of c-fos mRNA in VMC mice was also higher than that of the control group at 3 days and 7 days after virus inoculation.
Transcription (expression) of fos associated with coronary heart disease
6) Confidence 0.59 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 0.74 Pain Relevance 0.26
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Transcription (transcriptional) of FOS in lung associated with inflammation, aids-related complex and cytokine
7) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.03 Pain Relevance 0.17
Furthermore, the transcriptional activity of c-Jun and cFos can be inhibited by retinoic acid receptors in response to their ligands [49].
Transcription (activity) of cFos
8) Confidence 0.52 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.16 Pain Relevance 0
Up-regulated mRNA and protein expression of c-fos and fosB was abolished by SB204741, AG1478, and by U0126, an inhibitor of ERK phosphorylation by MAP kinase/ERK kinase.


Transcription (expression) of c-fos
9) Confidence 0.52 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Transcription (expression) of c-Fos
10) Confidence 0.52 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.46 Pain Relevance 0.95
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
Transcription (levels) of c-fos
11) Confidence 0.52 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.30 Pain Relevance 0.08
Thirty minutes following spatial training, there was a significant increase in the hippocampal transcript levels of Homer1a (2.6 fold), c-fos (1.8 fold), and zif268 (3.8 fold) relative to swim-control rats (Figure 6).


Transcription (transcript) of c-fos
12) Confidence 0.52 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911393 Disease Relevance 0 Pain Relevance 0.16
The response was dose-dependent with increases in c-fos and junB mRNA levels after dose of > or = 2 and 7 Gy, respectively.
Transcription (levels) of c-fos
13) Confidence 0.52 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332719 Disease Relevance 0.08 Pain Relevance 0.16
The relative abundance of the MHCI-HC, c-Fos and GFAP mRNA transcripts was calculated relative to the mRNA levels of the internal reference gene ?
Transcription (transcripts) of c-Fos in internal
14) Confidence 0.52 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
ERK(1/2) phosphorylation and c-Fos and FosB protein expression were determined with Western blotting, and c-fos and fosB mRNA expression with reverse transcription polymerase chain reaction.
Transcription (expression) of c-fos
15) Confidence 0.52 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
When compared to expression levels in the WT animal, the loss of photoreceptors resulted in reduced expression of the immediate early gene transcription factor cFos, as well as Slc1a3 and Grm1, a glutamate transporter and receptor, respectively.
Transcription (transcription) of cFos in photoreceptors associated with glutamate
16) Confidence 0.46 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.09 Pain Relevance 0.05
VMC mice were then treated with a c-fos monoclonal antibody and isoproterenol and the protein and mRNA expression of c-fos were studied via immunohistochemical analysis and in situ hybridization.
Transcription (expression) of fos associated with coronary heart disease
17) Confidence 0.44 Published 2010 Journal Virol J Section Abstract Doc Link PMC2976746 Disease Relevance 1.02 Pain Relevance 0
VMC mice were then treated with a c-fos monoclonal antibody and isoproterenol and the protein and mRNA expression of c-fos were studied via immunohistochemical analysis and in situ hybridization.
Transcription (expression) of fos associated with coronary heart disease
18) Confidence 0.44 Published 2010 Journal Virol J Section Abstract Doc Link PMC2976746 Disease Relevance 1.04 Pain Relevance 0
Brown-yellow particles in the cytoplasm indicated positive expression of c-fos oncogene mRNA.
Transcription (expression) of fos
19) Confidence 0.44 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 0.27 Pain Relevance 0
The expression level of c-fos mRNA at 3 and 7 days after virus inoculation in VMC mice was also higher than that of control mice.


Transcription (expression) of fos associated with coronary heart disease
20) Confidence 0.44 Published 2010 Journal Virol J Section Abstract Doc Link PMC2976746 Disease Relevance 1.05 Pain Relevance 0

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