INT47767

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.86
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
macrophages 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 84 100.00 Very High Very High Very High
Spinal cord 28 99.44 Very High Very High Very High
withdrawal 8 99.00 Very High Very High Very High
antagonist 1 87.36 High High
c fibre 28 85.60 High High
spinal dorsal horn 50 84.56 Quite High
Glutamate receptor 4 81.88 Quite High
agonist 2 80.64 Quite High
nMDA receptor 7 76.80 Quite High
Thermal hyperalgesia 2 72.88 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 6 99.00 Very High Very High Very High
Infection 1 90.40 High High
Nervous System Injury 1 76.24 Quite High
Ulcers 3 75.00 Quite High
Neuropathic Pain 3 73.84 Quite High
Hyperalgesia 8 72.88 Quite High
INFLAMMATION 3 48.40 Quite Low
Stomach Cancer 1 47.48 Quite Low
Pain 7 47.20 Quite Low
Disease 1 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of mice with an inhibitor of ERK phosphorylation attenuated phosphorylation of c-Fos, expression of ODC, and apoptosis in gastric macrophages.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of c-Fos in macrophages associated with apoptosis
1) Confidence 0.42 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20410304 Disease Relevance 0.58 Pain Relevance 0
Our results here show that targeted mutation of EphB1 receptor can prevent development of LTP and the associated phosphorylation of CaMKII and ERK and CREB and expression of c-Fos in the mouse SC.
Negative_regulation (prevent) of Phosphorylation (phosphorylation) of Fos associated with long-term potentiation and spinal cord
2) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.28 Pain Relevance 0.81
The adenylyl cyclase inhibitor 2',5'-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of c-fos mRNA associated with withdrawal
3) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.49

General Comments

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