INT47768

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Context Info
Confidence 0.11
First Reported 1995
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 14 99.82 Very High Very High Very High
tetrodotoxin 4 99.32 Very High Very High Very High
withdrawal 24 99.00 Very High Very High Very High
sodium channel 2 98.88 Very High Very High Very High
adenocard 4 98.74 Very High Very High Very High
Intracerebroventricular 8 98.48 Very High Very High Very High
antagonist 5 91.44 High High
nMDA receptor 4 90.16 High High
agonist 6 84.48 Quite High
tolerance 3 77.68 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular infusion of the sodium channel blocker, tetrodotoxin, decreased the glutamate-induced increase in phosphorylated cyclic AMP response-element binding protein, phosphorylated Elk-1, and Fos immunoreactivity.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of Fos associated with tetrodotoxin, glutamate, sodium channel and intracerebroventricular
1) Confidence 0.11 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.45
Simultaneous infusion of glutamate and Sp-8-Br-cAMPS, a cyclic AMP analogue, augmented induction of Fos immunoreactivity but not phosphorylated cyclic AMP response-element binding protein or phosphorylated Elk-1 immunoreactivity.
Positive_regulation (induction) of Neg (not) Phosphorylation (phosphorylated) of Fos associated with glutamate
2) Confidence 0.11 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.48
Intracerebroventricular infusion of 8-bromo-adenosine 3',5'-cyclic monophosphorothioate, Sp isomer (Sp-8-Br-cAMPS), increased phosphorylated cAMP-responsive element binding protein, phosphorylated Elk-1 and Fos immunoreactivity in a dose-dependent manner.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of Fos associated with adenocard and intracerebroventricular
3) Confidence 0.06 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113310 Disease Relevance 0 Pain Relevance 0.37
Intracerebroventricular infusion of 8-bromo-adenosine 3',5'-cyclic monophosphorothioate, Sp isomer (Sp-8-Br-cAMPS), increased phosphorylated cAMP-responsive element binding protein, phosphorylated Elk-1 and Fos immunoreactivity in a dose-dependent manner.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of Fos associated with adenocard and intracerebroventricular
4) Confidence 0.06 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113310 Disease Relevance 0 Pain Relevance 0.37
The adenylyl cyclase inhibitor 2',5'-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of c-fos mRNA associated with withdrawal
5) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.49
Prostaglandin E1, which activates adenylyl cyclase, caused concentration-dependent increases in the phosphorylation of CREB and in the abundance of c-fos mRNA.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of c-fos mRNA
6) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.48
Prostaglandin E1, which activates adenylyl cyclase, caused concentration-dependent increases in the phosphorylation of CREB and in the abundance of c-fos mRNA.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of c-fos mRNA
7) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.48

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