INT47769

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 3.03
Pain Relevance 8.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
macrophages 1
spinal cord 1
brain 1
striatum 1
amygdala 1
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 84 99.60 Very High Very High Very High
Glutamate 39 99.58 Very High Very High Very High
Dynorphin 5 99.48 Very High Very High Very High
Spinal cord 33 99.44 Very High Very High Very High
amygdala 2 99.40 Very High Very High Very High
nMDA receptor 18 99.30 Very High Very High Very High
tetrodotoxin 8 99.08 Very High Very High Very High
withdrawal 28 99.00 Very High Very High Very High
sodium channel 5 98.64 Very High Very High Very High
adenocard 6 98.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 5 99.42 Very High Very High Very High
Apoptosis 20 99.00 Very High Very High Very High
Reprotox - General 1 76 95.80 Very High Very High Very High
Drug Dependence 3 94.48 High High
Hyperalgesia 9 94.24 High High
Pain 10 91.08 High High
Infection 1 89.96 High High
Nociception 3 87.92 High High
Nervous System Injury 1 76.24 Quite High
Prostate Cancer 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala.
Phosphorylation (phosphorylated) of c-Fos in amygdala associated with anxiety disorder and amygdala
1) Confidence 0.61 Published 2004 Journal Neuropsychopharmacology Section Title Doc Link 14583739 Disease Relevance 0.51 Pain Relevance 0.27
Downstream the LHRH receptor, changes in protein expression of c-fos, phosphorylated p38 and phosphorylated ERK1/2 were analyzed by means of Western blotting after incubation with goserelin and irradiation with 4 Gy.
Phosphorylation (phosphorylated) of c-fos
2) Confidence 0.61 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC2034383 Disease Relevance 0.48 Pain Relevance 0
Downstream the LHRH receptor, changes in protein expression of c-fos, phosphorylated p38 and phosphorylated ERK1/2 were analyzed by means of Western blotting after incubation with goserelin and irradiation with 4 Gy.
Phosphorylation (phosphorylated) of c-fos
3) Confidence 0.61 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC2034383 Disease Relevance 0.48 Pain Relevance 0
Treatment of mice with an inhibitor of ERK phosphorylation attenuated phosphorylation of c-Fos, expression of ODC, and apoptosis in gastric macrophages.
Phosphorylation (phosphorylation) of c-Fos in macrophages associated with apoptosis
4) Confidence 0.61 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20410304 Disease Relevance 0.57 Pain Relevance 0
Moreover, prodynorphin (mRNA, real-time polymerase chain reaction), dynorphin (enzymatic immunoassay), c-Fos expression, and ERK1/2 phosphorylation (both by immunohistochemistry) in the lumbar spinal cord were assessed.
Phosphorylation (phosphorylation) of c-Fos in spinal cord associated with dynorphin and spinal cord
5) Confidence 0.61 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.35 Pain Relevance 1.10
Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not.
Phosphorylation (phosphorylated) of c-Fos associated with morphine
6) Confidence 0.61 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.61
Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not.
Phosphorylation (phosphorylated) of c-Fos associated with morphine
7) Confidence 0.61 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.68
ERK(1/2) phosphorylation and c-Fos and FosB protein expression were determined with Western blotting, and c-fos and fosB mRNA expression with reverse transcription polymerase chain reaction.
Phosphorylation (phosphorylation) of c-Fos
8) Confidence 0.61 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
Our results here show that targeted mutation of EphB1 receptor can prevent development of LTP and the associated phosphorylation of CaMKII and ERK and CREB and expression of c-Fos in the mouse SC.
Phosphorylation (phosphorylation) of Fos associated with long-term potentiation and spinal cord
9) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.28 Pain Relevance 0.81
Intracerebroventricular infusion of the sodium channel blocker, tetrodotoxin, decreased the glutamate-induced increase in phosphorylated cyclic AMP response-element binding protein, phosphorylated Elk-1, and Fos immunoreactivity.
Phosphorylation (phosphorylated) of Fos associated with tetrodotoxin, glutamate, sodium channel and intracerebroventricular
10) Confidence 0.17 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.45
Simultaneous infusion of glutamate and Sp-8-Br-cAMPS, a cyclic AMP analogue, augmented induction of Fos immunoreactivity but not phosphorylated cyclic AMP response-element binding protein or phosphorylated Elk-1 immunoreactivity.
Neg (not) Phosphorylation (phosphorylated) of Fos associated with glutamate
11) Confidence 0.17 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.48
These data indicate that cyclic AMP and mitogen-activated protein kinase signalling cascades are necessary for glutamate to induce cyclic AMP response-element binding protein and Elk-1 phosphorylation and Fos expression in the striatum.
Phosphorylation (phosphorylation) of Fos in striatum associated with glutamate
12) Confidence 0.13 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.43
Intracerebroventricular infusion of the mitogen-activated and extracellular signal-regulated kinase inhibitor, PD98059, the p38 mitogen-activated protein kinase inhibitor, SB203580, or the cyclic AMP inhibitor, Rp-8-Br-cAMPS, decreased glutamate-induced phosphorylated cyclic AMP response-element binding protein, phosphorylated Elk-1, and Fos immunoreactivity.
Phosphorylation (phosphorylated) of Fos associated with glutamate and intracerebroventricular
13) Confidence 0.13 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.48
The role of cyclic AMP and mitogen-activated protein kinase signalling cascades in glutamate-induced cyclic AMP response-element binding protein and Elk-1 phosphorylation and Fos expression was investigated using semiquantitative immunocytochemistry in vivo.
Phosphorylation (phosphorylation) of Fos associated with glutamate
14) Confidence 0.13 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.38
Intracerebroventricular infusion of 8-bromo-adenosine 3',5'-cyclic monophosphorothioate, Sp isomer (Sp-8-Br-cAMPS), increased phosphorylated cAMP-responsive element binding protein, phosphorylated Elk-1 and Fos immunoreactivity in a dose-dependent manner.
Phosphorylation (phosphorylated) of Fos associated with adenocard and intracerebroventricular
15) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113310 Disease Relevance 0 Pain Relevance 0.37
Intracerebroventricular infusion of 8-bromo-adenosine 3',5'-cyclic monophosphorothioate, Sp isomer (Sp-8-Br-cAMPS), increased phosphorylated cAMP-responsive element binding protein, phosphorylated Elk-1 and Fos immunoreactivity in a dose-dependent manner.
Phosphorylation (phosphorylated) of Fos associated with adenocard and intracerebroventricular
16) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113310 Disease Relevance 0 Pain Relevance 0.37
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Phosphorylation (phosphorylated) of c-fos mRNA in brain associated with glutamate, nmda receptor, narcan and withdrawal
17) Confidence 0.09 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.35 Pain Relevance 0.92
Intracerebroventricular infusion of the N-methyl-D-aspartate antagonist, MK801, decreased, but tetrodotoxin or the mitogen-activated extracellular-regulated kinase inhibitor, PD98059, did not affect Sp-8-Br-cAMPS-induced phosphorylated c-AMP-responsive element binding protein, phosphorylated Elk-1, phosphorylated extracellular-signal-regulated kinase and Fos immunoreactivity.
Phosphorylation (phosphorylated) of Fos associated with tetrodotoxin, antagonist and intracerebroventricular
18) Confidence 0.07 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113310 Disease Relevance 0 Pain Relevance 0.38
Prostaglandin E1, which activates adenylyl cyclase, caused concentration-dependent increases in the phosphorylation of CREB and in the abundance of c-fos mRNA.
Phosphorylation (phosphorylation) of c-fos mRNA
19) Confidence 0.02 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.47
The adenylyl cyclase inhibitor 2',5'-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.
Phosphorylation (phosphorylation) of c-fos mRNA associated with withdrawal
20) Confidence 0.02 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.49

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