INT47770

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.87
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
osteoclast 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 24 99.98 Very High Very High Very High
Paracetamol 7 98.24 Very High Very High Very High
rheumatoid arthritis 34 95.48 Very High Very High Very High
withdrawal 8 95.08 Very High Very High Very High
Spinal cord 9 93.28 High High
Hippocampus 45 92.60 High High
Inflammatory response 1 90.48 High High
antagonist 4 87.52 High High
agonist 2 83.24 Quite High
Inflammation 37 83.00 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 99.04 Very High Very High Very High
Rheumatoid Arthritis 34 95.48 Very High Very High Very High
INFLAMMATION 36 90.48 High High
Necrosis 3 88.08 High High
Arthritis 19 81.36 Quite High
Neurodegenerative Disease 4 75.84 Quite High
Stress 67 75.00 Quite High
Hepatocellular Cancer 4 62.16 Quite High
Osteoporosis 1 60.40 Quite High
Seronegative Spondarthritis 2 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-receptor type 1 involves mitogen-activated protein kinases (MAPKs) and NFkB, which then activate key transcription factors for osteoclast formation, such as c-fos of the activator protein-1 family or NFATc1.
Positive_regulation (activate) of Transcription (transcription) of c-fos in osteoclast
1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.72 Pain Relevance 0.37
The time-course study showed that c-fos mRNA level was maximal at 10 min and began to decrease 30 min after the Sub P injection in all tissues, and the Sub P-induced increase of the c-fos mRNA level was returned to the control level 1 h after the injection.
Positive_regulation (increase) of Transcription (level) of c-fos mRNA
2) Confidence 0.48 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.39
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
Positive_regulation (increased) of Transcription (levels) of c-fos
3) Confidence 0.45 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.31 Pain Relevance 0.08
Thirty minutes following spatial training, there was a significant increase in the hippocampal transcript levels of Homer1a (2.6 fold), c-fos (1.8 fold), and zif268 (3.8 fold) relative to swim-control rats (Figure 6).


Positive_regulation (increase) of Transcription (transcript) of c-fos
4) Confidence 0.45 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911393 Disease Relevance 0 Pain Relevance 0.16
Furthermore, c-jun, but not c-fos, mRNA transcripts were transiently increased following exposure to hepatotoxic doses of APAP.
Positive_regulation (increased) of Transcription (transcripts) of fos associated with paracetamol
5) Confidence 0.31 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.58 Pain Relevance 0.54
LMW-PTP action is exerted during the G1 phase of the cell cycle and affects myc and fos gene transcription induced by PDGF-receptors activation [33].
Positive_regulation (induced) of Transcription (transcription) of fos
6) Confidence 0.29 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.15 Pain Relevance 0.04
In particular, the SRE element is an important region of the PKC-induced transcription of the c-fos gene, mediated by the activation of the ERK signaling cascade.
Positive_regulation (mediated) of Transcription (transcription) of fos associated with kinase c
7) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.33
In particular, the SRE element is an important region of the PKC-induced transcription of the c-fos gene, mediated by the activation of the ERK signaling cascade.
Positive_regulation (induced) of Transcription (transcription) of fos associated with kinase c
8) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.33
Prostaglandin E1, which activates adenylyl cyclase, caused concentration-dependent increases in the phosphorylation of CREB and in the abundance of c-fos mRNA.
Positive_regulation (increases) of Transcription (abundance) of c-fos mRNA
9) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.48

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