INT47804

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Context Info
Confidence 0.29
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.94
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gspt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 13 98.32 Very High Very High Very High
Enkephalin 6 97.78 Very High Very High Very High
anesthesia 2 97.08 Very High Very High Very High
antagonist 2 96.08 Very High Very High Very High
agonist 4 83.80 Quite High
adenocard 6 83.36 Quite High
withdrawal 2 75.20 Quite High
MU agonist 1 75.00 Quite High
opioid receptor 1 63.60 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 1 99.78 Very High Very High Very High
Hyperalgesia 15 98.32 Very High Very High Very High
Rickettsiaceae Infection 54 98.00 Very High Very High Very High
Chronic Disease 9 95.24 Very High Very High Very High
Nociception 1 84.16 Quite High
Cv Unclassified Under Development 5 57.60 Quite High
Congenital Anomalies 8 48.16 Quite Low
Infection 9 47.40 Quite Low
Fatigue 6 32.16 Quite Low
Depression 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary objective of the present study was to determine whether those same lines also differed in hepatic Phase I enzyme activity, estimated from sleep time (ST) following sodium pentobarbital anesthesia.
Spec (whether) Negative_regulation (differed) of Phase I enzyme associated with anesthesia
1) Confidence 0.29 Published 2003 Journal J. Anim. Sci. Section Abstract Doc Link 14552384 Disease Relevance 0 Pain Relevance 0.17
Hyperalgesia produced by all five analogs was significantly attenuated or completely blocked by inhibiting stimulatory guanine nucleotide-binding regulatory protein with guanosine 5'-O-(2-thiodiphosphate), adenylyl cyclase with 2'5'-dideoxyadenosine and protein kinase A with WIPTIDE.
Negative_regulation (inhibiting) of stimulatory guanine nucleotide-binding regulatory protein associated with hyperalgesia
2) Confidence 0.21 Published 1995 Journal Neuroscience Section Abstract Doc Link 7753383 Disease Relevance 0.67 Pain Relevance 0.80
The decrease in sensitivity to prostaglandin E2- and CGS21680-induced hyperalgesia by preadministration of [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin or N6-cyclopentyladenosine and the enhancement by postadministration were all reversed by pertussis toxin, an inhibitor of inhibitory guanine nucleotide-binding regulatory protein, suggesting the involvement of an inhibitory guanine nucleotide-binding regulatory protein.
Negative_regulation (inhibitor) of guanine nucleotide-binding regulatory protein associated with hyperalgesia, bordatella infection and enkephalin
3) Confidence 0.06 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477899 Disease Relevance 0.55 Pain Relevance 1.07
Furthermore, at follow-up, all of these patients showed a spontaneous subsequent decline in anti-phase I IgG titres, which, in the case of a possible chronic Q fever, is highly unlikely, given the natural detrimental course of chronic disease if left untreated.
Spec (possible) Negative_regulation (decline) of anti-phase I IgG associated with rickettsiaceae infection and chronic disease
4) Confidence 0.04 Published 2010 Journal Infection Section Body Doc Link PMC3003145 Disease Relevance 0.71 Pain Relevance 0

General Comments

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