INT47805

Context Info Confidence 0.11 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.02 Pain Relevance 0.47

Anatomy Link Frequency skin 1 Gspt1 (Mus musculus)

Pain Link Frequency Relevance Heat Hyperalgesia 5 95.20 Inflammatory response 5 87.84 adenocard 6 78.32 MU agonist 1 75.00 withdrawal 1 67.84 agonist 10 54.80 Inflammation 26 53.04 cytokine 8 52.00 member 8 2 47.36 Enkephalin 6 40.64

Disease Link Frequency Relevance Heat Rickettsiaceae Infection 54 99.20 Hyperalgesia 7 95.20 INFLAMMATION 29 87.84 Infection 9 82.60 Fatigue 6 67.36 Pneumonia 4 48.60 Chronic Disease 9 46.48 Dermatitis 6 40.80 Lower Respiratory Tract Infection 1 39.52 Syndrome 1 37.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Guanine nucleotide-binding regulatory protein stimulation of adenylyl cyclase has been shown to be an important second messenger system for many processes, including mechanical hyperalgesia.

Positive_regulation (stimulation) of Guanine nucleotide-binding regulatory protein associated with hyperalgesia

1) Confidence 0.11 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477899 Disease Relevance 0.23 Pain Relevance 0.37

The anti-phase I IgG kinetic, with a titre peak at 3 months, is different from the available literature on IFA serological patterns in the follow-up of acute Q fever, which shows a rather slow and gradual increase of anti-phase I IgG antibodies [22, 23].

Positive_regulation (increase) of anti-phase I IgG associated with rickettsiaceae infection

2) Confidence 0.07 Published 2010 Journal Infection Section Body Doc Link PMC3003145 Disease Relevance 0.65 Pain Relevance 0

B cells do not accumulate in the skin, but their activation in adult K5-R1/R2 mice was demonstrated by the presence of enhanced levels of Igs G1, G2a, and E in the dermis and of IgE in the serum (Fig. 5 C).

Positive_regulation (enhanced) of Igs G1 in skin

3) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.14 Pain Relevance 0.10

Asp83 (marked green in Fig. 6) reports only very slight changes in the H1/H2/H7 network in the transitions from the dark state to Lumi and Meta I, and a major change in the transition to Meta II, downshifting the absorption of Asp83 by approximately 20 cm?

Positive_regulation (change) of transition

4) Confidence 0.01 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0

Such a translational movement of retinal of approximately 4 Å was shown to take place during receptor activation in the transition to Meta II in solid-state NMR experiments.38 In the active conformation of Meta III, the retinal all-trans 15-syn isomer presumably occupies a position quite similar to that of the all-trans 15-anti isomer in Meta II.

Positive_regulation (activation) of transition

5) Confidence 0.01 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0

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