INT47806

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.25
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gspt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 99.52 Very High Very High Very High
adenocard 6 97.56 Very High Very High Very High
withdrawal 1 84.64 Quite High
Central nervous system 7 77.04 Quite High
MU agonist 1 75.00 Quite High
agonist 4 71.60 Quite High
Enkephalin 6 57.44 Quite High
opioid receptor 1 56.08 Quite High
Analgesic 2 25.00 Low Low
cva 5 14.28 Low Low
Disease Link Frequency Relevance Heat
Gastrointestinal Stromal Tumor 85 100.00 Very High Very High Very High
Hyperalgesia 7 99.52 Very High Very High Very High
Leiomyosarcoma 2 98.04 Very High Very High Very High
Uterine Fibroids 2 96.96 Very High Very High Very High
Cancer 73 96.08 Very High Very High Very High
Malignant Neoplastic Disease 27 89.16 High High
Leukemia 3 88.00 High High
Myeloid Leukemia 3 85.92 High High
Disease Progression 7 79.00 Quite High
Rupture 4 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was published in 1997, prior to the recognition of GIST as a distinct pathologic entity.
GIST Binding (recognition) of associated with gastrointestinal stromal tumor
1) Confidence 0.47 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.18 Pain Relevance 0
It specifically targets the c-kit (CD117) proto-oncogene gain of function mutation characterising GISTs, blocking the c-kit kinase, leading to growth cessation and significant durable clinical remissions.
GIST Binding (targets) of
2) Confidence 0.36 Published 2004 Journal BMC Cancer Section Body Doc Link PMC524360 Disease Relevance 0.82 Pain Relevance 0.04
Recently, interactions between guanine nucleotide-binding regulatory protein subunits and adenylyl cyclase affecting the level of cyclic adenosine 3',5'-monophosphate accumulation have been demonstrated.
guanine nucleotide-binding regulatory protein Binding (interactions) of associated with adenocard
3) Confidence 0.08 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477899 Disease Relevance 0.25 Pain Relevance 0.58

General Comments

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