INT4781

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Context Info
Confidence 0.73
First Reported 1981
Last Reported 2010
Negated 2
Speculated 8
Reported most in Abstract
Documents 68
Total Number 90
Disease Relevance 26.92
Pain Relevance 24.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
neurons 19
nerve 6
striatum 3
DA neurons 3
thyroid gland 2
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1153 100.00 Very High Very High Very High
midbrain 366 100.00 Very High Very High Very High
Neuropeptide 105 100.00 Very High Very High Very High
substance P 71 100.00 Very High Very High Very High
Enkephalin 48 100.00 Very High Very High Very High
Neurotransmitter 32 100.00 Very High Very High Very High
Calcitonin gene-related peptide 25 100.00 Very High Very High Very High
Serotonin 20 100.00 Very High Very High Very High
Catecholamine 11 100.00 Very High Very High Very High
Tetrahydrobiopterin 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 25 100.00 Very High Very High Very High
Restless Legs Syndrome 786 99.98 Very High Very High Very High
Coronary Heart Disease 11 99.96 Very High Very High Very High
INFLAMMATION 86 99.72 Very High Very High Very High
Ganglion Cysts 16 99.68 Very High Very High Very High
Death 160 99.66 Very High Very High Very High
Neuroblastoma 18 99.44 Very High Very High Very High
Cancer 21 99.24 Very High Very High Very High
Disease 1008 99.20 Very High Very High Very High
Graves' Ophthalmopathy 9 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the expression of three neuropeptides that have been implicated in nociceptive transmission, and the sympathetic nerve fiber marker tyrosine hydroxylase, in 11 painful human Morton's neuromas, using immunohistochemistry.
Spec (examined) Gene_expression (expression) of tyrosine hydroxylase in sympathetic associated with nociception, pain, neuropeptide and neuroma
1) Confidence 0.73 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10918258 Disease Relevance 0.43 Pain Relevance 0.41
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Gene_expression (express) of TH in neurons associated with generalized anxiety disorder
2) Confidence 0.71 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
Peptide immunoreactivity in nerve fibres was correlated with the presence of tyrosine hydroxylase (TH).
Gene_expression (presence) of tyrosine hydroxylase in nerve
3) Confidence 0.66 Published 1994 Journal Arch. Oral Biol. Section Abstract Doc Link 7517137 Disease Relevance 0 Pain Relevance 0.16
Peptide immunoreactivity in nerve fibres was correlated with the presence of tyrosine hydroxylase (TH).
Gene_expression (presence) of TH in nerve
4) Confidence 0.66 Published 1994 Journal Arch. Oral Biol. Section Abstract Doc Link 7517137 Disease Relevance 0 Pain Relevance 0.16
An initial histological experiment verified the existence of dopamine neurons within the vPAG using dopamine transporter and tyrosine hydroxylase antibodies visualized with confocal microscopy.
Gene_expression (using) of tyrosine hydroxylase in dopamine neurons
5) Confidence 0.65 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19225762 Disease Relevance 0.09 Pain Relevance 0
Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.
Gene_expression (receptors) of TH
6) Confidence 0.65 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
The human fetal sympathetic ganglia were studied using the indirect peroxidase-antiperoxidase PAP method for immunocytochemical demonstration of three catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) as well as the neuropeptides leucine (Leu5)-enkephalin and substance P.
Gene_expression (using) of tyrosine hydroxylase in ganglia associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
7) Confidence 0.65 Published 1981 Journal Cell Tissue Res. Section Abstract Doc Link 6162566 Disease Relevance 0.07 Pain Relevance 0.46
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Gene_expression (expression) of tyrosine hydroxylase associated with dopamine and opiate addiction
8) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.24 Pain Relevance 0.41
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Gene_expression (expression) of TH associated with dopamine and opiate addiction
9) Confidence 0.64 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.24 Pain Relevance 0.41
The latter is also associated with loss of nNOS and TH expression but by contrast, presents with increased expression of SP [26], suggesting regional variations in the effects of diabetes on the enteric nervous system.
Gene_expression (expression) of TH in enteric nervous system associated with diabetes mellitus and substance p
10) Confidence 0.63 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.70 Pain Relevance 0.11
Using indirect immunohistochemistry, we analyzed the distribution of calretinin (CR), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA), vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS), tyrosine hydroxylase (TH), histamine, serotonin, enkephalin, and, enzyme histochemically, NADPH-diaphorase (NADPH-d).
Spec (analyzed) Gene_expression (distribution) of tyrosine hydroxylase associated with neuropeptide, enkephalin, serotonin, substance p and calcitonin gene-related peptide
11) Confidence 0.59 Published 1997 Journal Acta Histochem. Section Abstract Doc Link 9381913 Disease Relevance 0 Pain Relevance 0.63
Using indirect immunohistochemistry, we analyzed the distribution of calretinin (CR), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA), vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS), tyrosine hydroxylase (TH), histamine, serotonin, enkephalin, and, enzyme histochemically, NADPH-diaphorase (NADPH-d).
Spec (analyzed) Gene_expression (distribution) of TH associated with neuropeptide, enkephalin, serotonin, substance p and calcitonin gene-related peptide
12) Confidence 0.59 Published 1997 Journal Acta Histochem. Section Abstract Doc Link 9381913 Disease Relevance 0 Pain Relevance 0.63
Finally, one of the markers associated with the mature dopaminergic neuronal phenotype, tyrosine hydroxylase (TH) was also expressed (Figure 4E).
Gene_expression (expressed) of TH in neuronal
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.28
Finally, one of the markers associated with the mature dopaminergic neuronal phenotype, tyrosine hydroxylase (TH) was also expressed (Figure 4E).
Gene_expression (expressed) of tyrosine hydroxylase in neuronal
14) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.29
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Gene_expression (express) of tyrosine hydroxylase in neurons associated with generalized anxiety disorder
15) Confidence 0.55 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
Alternatively, these could also be processes from intrinsic neurons as there is a subset of enteric nerves that also expresses TH [37].
Gene_expression (expresses) of TH in intrinsic neurons
16) Confidence 0.55 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.61 Pain Relevance 0
The results indicated that treatment with Bt2cAMP and TPA induces the expression of multiple genes of peptide hormone and tyrosine hydroxylase and increases hormone production and secretion through morphological changes into endocrine cells.
Gene_expression (expression) of tyrosine hydroxylase in endocrine cells
17) Confidence 0.53 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.14 Pain Relevance 0.26
The production and secretion of multiple peptide hormones and tyrosine hydroxylase by the human neuroblastoma cell line NB-1 and the effects of dibutyryl cAMP (Bt2cAMP) and phorbol esters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on them were investigated.
Spec (investigated) Gene_expression (production) of tyrosine hydroxylase associated with neuroblastoma
18) Confidence 0.53 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.17 Pain Relevance 0.11
The expression of neuropeptides, and the enzymes nitric oxide synthase and tyrosine hydroxylase were examined in intramural ganglia of human urinary bladder using single label immunocytochemistry.
Spec (examined) Gene_expression (expression) of tyrosine hydroxylase in urinary bladder associated with neuropeptide
19) Confidence 0.51 Published 1996 Journal J. Neurocytol. Section Abstract Doc Link 8699193 Disease Relevance 0 Pain Relevance 0.19
The majority of GABA+ cells (93%) coexpressed TH (Figure 4C).
Gene_expression (coexpressed) of TH associated with gaba
20) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.28

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