INT47812

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Context Info
Confidence 0.51
First Reported 1994
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.99
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
nucleus 4
neuronal 2
hypothalamic nucleus 2
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 13 100.00 Very High Very High Very High
medulla 17 99.68 Very High Very High Very High
gABA 2 99.52 Very High Very High Very High
Catecholamine 2 98.68 Very High Very High Very High
Dopamine 7 92.64 High High
Glutamate 1 92.00 High High
Neurotransmitter 9 90.52 High High
antagonist 6 85.04 High High
Central nervous system 3 84.52 Quite High
noradrenaline 2 83.60 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 3 99.32 Very High Very High Very High
Hypertension 19 98.96 Very High Very High Very High
Ganglion Cysts 3 98.32 Very High Very High Very High
Heart Rate Under Development 7 97.68 Very High Very High Very High
Pressure Volume 2 Under Development 2 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tetrodotoxin suppressed the release of L-DOPA, but partially inhibited hypertension with only a slight inhibition of tachycardia evoked by stimulation of the posterior hypothalamic nucleus.
Negative_regulation (suppressed) of Localization (release) of L-DOPA in hypothalamic nucleus associated with tetrodotoxin, heart rate under development and hypertension
1) Confidence 0.51 Published 1999 Journal Neuroscience Section Abstract Doc Link 10392836 Disease Relevance 0.49 Pain Relevance 0.73
Tonic neuronal L-DOPA release is impaired in this nucleus of spontaneously hypertensive rats.
Negative_regulation (impaired) of Localization (release) of L-DOPA in nucleus associated with hypertension
2) Confidence 0.37 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477914 Disease Relevance 0.71 Pain Relevance 0.32
Tonic neuronal activity to release L-DOPA is lost in the CVLM of adult SHR and this loss may contribute to maintenance of hypertension in SHR.
Negative_regulation (lost) of Localization (release) of L-DOPA in neuronal associated with medulla and hypertension
3) Confidence 0.37 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8570091 Disease Relevance 0.33 Pain Relevance 0.49
By parallel microdialysis in bilateral nucleus tractus solitarii areas, the basal L-DOPA release was in part inhibited by tetrodotoxin perfusion (1 microM) or Ca2+ deprivation, and was markedly reduced by alpha-methyl-p-tyrosine (200 mg/kg, i.p.), a tyrosine hydroxylase inhibitor.
Negative_regulation (reduced) of Localization (release) of L-DOPA in nucleus associated with tetrodotoxin
4) Confidence 0.36 Published 1994 Journal Neuroscience Section Abstract Doc Link 7816196 Disease Relevance 0.12 Pain Relevance 0.30
In the NTS, GABA tonically functions to inhibit via GABAA receptors L-DOPA release and depressor responses to L-DOPA, whereas L-DOPA induces GABA release.
Negative_regulation (inhibit) of Localization (release) of L-DOPA associated with gaba
5) Confidence 0.24 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8532212 Disease Relevance 0.33 Pain Relevance 0.96

General Comments

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