INT47817

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 3.70
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
hippocampus 4
nucleus accumbens 2
spinal cord 2
neurons 2
striatum 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 24 100.00 Very High Very High Very High
c fibre 5 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
neuralgia 1 100.00 Very High Very High Very High
depression 9 99.98 Very High Very High Very High
withdrawal 6 99.92 Very High Very High Very High
Morphine 5 99.48 Very High Very High Very High
Inflammation 26 99.44 Very High Very High Very High
Hippocampus 19 99.44 Very High Very High Very High
Spinal cord 3 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 9 99.98 Very High Very High Very High
Cancer 16 99.84 Very High Very High Very High
Disease 1 99.80 Very High Very High Very High
INFLAMMATION 27 99.44 Very High Very High Very High
Neuropathic Pain 5 97.40 Very High Very High Very High
Apoptosis 4 93.04 High High
Death 1 90.24 High High
Nervous System Injury 7 88.84 High High
Convulsion 4 86.56 High High
Hypersensitivity 1 81.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, by using gel shift assay we found an induction of AP-1 by caffeine (100 mg/kg) in striatum, which peaked 2 hr after administration and was clearly increased after 4 hr. c-Fos, c-Jun, and JunB proteins were components of the AP-1.
Positive_regulation (increased) of Positive_regulation (induction) of AP-1 in striatum
1) Confidence 0.66 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.
Positive_regulation (caused) of Positive_regulation (induction) of c-jun
2) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
In addition, the pre-administration with L-NAME further increased the KA-induced AP-1 and ENKCRE-2 DNA binding activities.
Positive_regulation (increased) of Positive_regulation (induced) of AP-1
3) Confidence 0.46 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
Increased levels of c-fos and c-jun mRNA were observed in the spinal cord at 40 min of morphine withdrawal.
Positive_regulation (Increased) of Positive_regulation (Increased) of c-jun mRNA in spinal cord associated with withdrawal, morphine and spinal cord
4) Confidence 0.43 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532189 Disease Relevance 0 Pain Relevance 1.04
The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA.
Positive_regulation (induces) of Positive_regulation (induction) of c-jun
5) Confidence 0.42 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.11
A strong induction of junB, a weak induction of c-fos and c-jun, but not of junD, was seen in nucleus accumbens.
Positive_regulation (induction) of Positive_regulation (induction) of c-jun in nucleus accumbens associated with nucleus accumbens
6) Confidence 0.42 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
Activation of transcription factor c-jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain.
Positive_regulation (induces) of Positive_regulation (Activation) of c-jun in dorsal root ganglia associated with neuralgia and neuropathic pain
7) Confidence 0.40 Published 2007 Journal Exp. Neurol. Section Title Doc Link 17081520 Disease Relevance 0.94 Pain Relevance 0.97
The pre-administration with L-NAME further increased KA-induced c-jun and c-fos mRNA levels in addition to their protein product levels, although the pre-treatment with L-NAME did not affect KA-induced FosB, Fra-2, JunB, and JunD protein levels at 6 h after treatment.
Positive_regulation (increased) of Positive_regulation (induced) of c-jun
8) Confidence 0.40 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
Stimulation with nicotine also caused a drastic increase in the mRNA levels, whereas muscarine only induced moderate elevations. c-fos and c-jun were induced strongly in adrenaline cells and only weakly in noradrenaline cells. junB was upregulated mainly in adrenaline cells.
Positive_regulation (induced) of Positive_regulation (upregulated) of c-jun associated with nicotine and noradrenaline
9) Confidence 0.39 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.46
Stimulation with nicotine also caused a drastic increase in the mRNA levels, whereas muscarine only induced moderate elevations. c-fos and c-jun were induced strongly in adrenaline cells and only weakly in noradrenaline cells. junB was upregulated mainly in adrenaline cells.
Positive_regulation (upregulated) of Positive_regulation (induced) of c-jun associated with nicotine and noradrenaline
10) Confidence 0.39 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.46
The increases of c-Fos, 35-kDa Fra and c-Jun protein levels induced by KA administration were also inhibited by CHX pre-administration.
Positive_regulation (increases) of Positive_regulation (increases) of c-Jun
11) Confidence 0.37 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
Administration of kainate to rats caused a profound increase in messenger RNAs of the transcription factor genes c-fos and c-jun in the dentate gyrus, followed by an increase in the level of the transcriptional complex activator protein-1 in hippocampal neurons.
Positive_regulation (caused) of Positive_regulation (increase) of c-jun in neurons
12) Confidence 0.37 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477937 Disease Relevance 0.31 Pain Relevance 0.11
MK-801 blocked these changes in ITF expressions, but it could also cause the C-fibre stimulations to induce c-Fos and c-Jun in specific areas of the hippocampus.
Positive_regulation (cause) of Positive_regulation (induce) of c-Jun in hippocampus associated with c fibre and hippocampus
13) Confidence 0.37 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0 Pain Relevance 0.53
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Positive_regulation (returned) of Positive_regulation (induced) of c-jun associated with nicotine
14) Confidence 0.34 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.49
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Positive_regulation (induced) of Positive_regulation (induced) of c-jun associated with nicotine
15) Confidence 0.34 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.46
Furthermore, western immunoblot assay showed that PMA caused induction of c-Fos, Fra-1, and c-Jun protein levels.
Positive_regulation (caused) of Positive_regulation (induction) of c-Jun
16) Confidence 0.33 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
Because R-flurbiprofen does not cause gastrointestinal mucosal damage or other side effects associated with long-term NSAID or glucocorticoid use, it might be a useful drug in inflammatory or other diseases in which increased or constitutive NF-kB and AP-1 activation are involved in the pathophysiological processes.
Positive_regulation (increased) of Positive_regulation (activation) of AP-1 associated with inflammation, cinod and disease
17) Confidence 0.20 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.47 Pain Relevance 0.46
Prazosin reduced FCL(SD)-induced elevations of c-jun and c-fos, but not NGFI-A, mRNA.
Neg (not) Positive_regulation (-induced) of Positive_regulation (elevations) of c-jun associated with depression
18) Confidence 0.15 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.60 Pain Relevance 0.67
Our results suggest that the phosphorylation of JNK is involved in the up-regulation of the proenkephalin gene expression via c-Fos and c-Jun that is induced by KA in rat hippocampus.
Positive_regulation (induced) of Positive_regulation (up-regulation) of c-Jun in hippocampus associated with hippocampus
19) Confidence 0.14 Published 2001 Journal Mol. Cells Section Abstract Doc Link 11355693 Disease Relevance 0 Pain Relevance 0.27
In contrast, some studies have reported that aspirin exerts antitumor effects partly through blocking the induction of activator protein-1 (AP-1) activation by tumor promoters [59].
Positive_regulation (induction) of Positive_regulation (activation) of activator protein-1 associated with aspirin and cancer
20) Confidence 0.13 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.67 Pain Relevance 0.21

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