INT47818

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 48
Total Number 51
Disease Relevance 11.11
Pain Relevance 24.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
neurons 7
brain 3
neural 3
striatum 2
hippocampus 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 15 99.92 Very High Very High Very High
dopamine receptor 37 99.84 Very High Very High Very High
Spinal cord 26 99.84 Very High Very High Very High
cocaine 157 99.82 Very High Very High Very High
Analgesic 11 99.78 Very High Very High Very High
Opioid 54 99.76 Very High Very High Very High
agonist 32 99.76 Very High Very High Very High
Morphine 53 99.70 Very High Very High Very High
anticonvulsant 8 99.70 Very High Very High Very High
amygdala 10 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 29 100.00 Very High Very High Very High
Nociception 12 99.98 Very High Very High Very High
Frailty 6 99.92 Very High Very High Very High
Avian Sarcoma 1 99.84 Very High Very High Very High
Convulsion 22 98.68 Very High Very High Very High
Pain 20 98.52 Very High Very High Very High
INFLAMMATION 8 98.36 Very High Very High Very High
Inflammatory Pain 6 98.32 Very High Very High Very High
Shock 134 97.84 Very High Very High Very High
Targeted Disruption 46 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis revealed that the level of Vesl-1L protein did not increase after the application of a maximum electroconvulsive shock (MECS) in the hippocampus of KO mice and was comparable to that of wild type mice in the condition where the level of Vesl-1S protein was increased (Figure 2c).
Positive_regulation (increased) of Vesl-1S protein in hippocampus associated with shock and hippocampus
1) Confidence 0.70 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.25 Pain Relevance 0.12
All of these in vivo effects were observed at a relatively early time point (1 to 2 h after injection) and were connected with the induction of a group of immediate early gene (IEG) transcription factors and neuroplasticity-related genes like Fos, Arc, Npas4 and Homer1.
Positive_regulation (induction) of immediate early gene associated with aids-related complex
2) Confidence 0.65 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.10 Pain Relevance 0.18
The vesl-1S and vesl-1M mRNAs (short forms) genes are upregulated as immediate early genes during convulsive seizures and LTP [4,10].
Positive_regulation (upregulated) of vesl-1M associated with convulsion
3) Confidence 0.61 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.17 Pain Relevance 0.08
The vesl-1S and vesl-1M mRNAs (short forms) genes are upregulated as immediate early genes during convulsive seizures and LTP [4,10].
Positive_regulation (upregulated) of vesl-1S associated with convulsion
4) Confidence 0.61 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.17 Pain Relevance 0.08
Anticonvulsant agents, dizocilpine maleate, enadoline and HA 966 have different effects on N-methyl-DL-aspartate-induced immediate early gene induction in mice.
Positive_regulation (induction) of early gene associated with anticonvulsant
5) Confidence 0.57 Published 1993 Journal Neuroscience Section Title Doc Link 8255428 Disease Relevance 0.10 Pain Relevance 0.26
Pre-treatment with the anticonvulsant agent enadoline (3 mg/kg), given at an anticonvulsant dose, did not result in reduced immediate early gene messenger RNA levels.
Neg (not) Positive_regulation (result) of immediate early gene messenger RNA associated with anticonvulsant
6) Confidence 0.47 Published 1993 Journal Neuroscience Section Abstract Doc Link 8255428 Disease Relevance 0.06 Pain Relevance 0.39
Western blot analysis revealed that the level of Vesl-1L protein did not increase after the application of a maximum electroconvulsive shock (MECS) in the hippocampus of KO mice and was comparable to that of wild type mice in the condition where the level of Vesl-1S protein was increased (Figure 2c).
Neg (not) Positive_regulation (increase) of Vesl-1L in hippocampus associated with shock and hippocampus
7) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.20 Pain Relevance 0.11
Because genomic DNA of KO mice lacked these poly(A) sites and the expression of knocked-in vesl-1L mRNA was directed by the endogenous vesl-1 promoter, we wondered whether the level of Vesl-1L protein was augmented in a neural activity-dependent manner.
Spec (whether) Positive_regulation (augmented) of Vesl-1L in neural
8) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.17 Pain Relevance 0.07
Short form Vesl is unique among the Vesl family proteins in that its expression is upregulated by various neural activities.
Positive_regulation (upregulated) of Vesl in neural
9) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.36 Pain Relevance 0
Generation of vesl-1 short form-specific KO mice
Positive_regulation (Generation) of vesl-1
10) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.24 Pain Relevance 0
All of these in vivo effects were observed at a relatively early time point (1 to 2 h after injection) and were connected with the induction of a group of immediate early gene (IEG) transcription factors and neuroplasticity-related genes like Fos, Arc, Npas4 and Homer1.
Positive_regulation (induction) of Homer1 associated with aids-related complex
11) Confidence 0.43 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.10 Pain Relevance 0.19
Homer1a is rapidly and selectively upregulated in spinal cord neurons after peripheral inflammation in an NMDA receptor-dependent manner.
Positive_regulation (upregulated) of Homer1a in spinal cord neurons associated with inflammation, nmda receptor and spinal cord
12) Confidence 0.41 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16715092 Disease Relevance 0.64 Pain Relevance 0.76
Preventing activity-induced upregulation of Homer1a using shRNAs in mice in vivo exacerbates inflammatory pain.
Positive_regulation (upregulation) of Homer1a associated with ipn
13) Confidence 0.41 Published 2006 Journal Nat. Med. Section Abstract Doc Link 16715092 Disease Relevance 0.86 Pain Relevance 1.04
Because genomic DNA of KO mice lacked these poly(A) sites and the expression of knocked-in vesl-1L mRNA was directed by the endogenous vesl-1 promoter, we wondered whether the level of Vesl-1L protein was augmented in a neural activity-dependent manner.
Positive_regulation (directed) of vesl-1 in neural
14) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.04
The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in mice.
Neg (not) Positive_regulation (induction) of immediate early gene
15) Confidence 0.36 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15128409 Disease Relevance 0 Pain Relevance 0.62
These results demonstrate that some of the effects of cocaine on gene regulation are mediated via D1 receptor-dependent mechanisms, as evidenced by the absence of immediate-early gene induction in D1-deficient mice, whereas others also involve additional, non-D1 receptor mechanisms, as shown for substance P expression.
Positive_regulation (induction) of immediate-early gene associated with substance p and cocaine
16) Confidence 0.33 Published 1996 Journal Neuroscience Section Abstract Doc Link 8884777 Disease Relevance 0 Pain Relevance 0.53
Oxytocin neurones were activated during birth as shown by both increased immediate early gene ( Fos) expression in oxytocin neurones in the supraoptic nucleus and increased plasma oxytocin concentrations during birth.
Positive_regulation (increased) of immediate early gene in plasma
17) Confidence 0.19 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.13 Pain Relevance 0.07
As an immediate-early gene, COX-2 is dramatically and transiently induced in these neurons in response to NMDA receptor activation.
Positive_regulation (induced) of immediate-early gene in neurons associated with nmda receptor
18) Confidence 0.19 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11588192 Disease Relevance 0.61 Pain Relevance 0.36
D1R mutants do not become locomotor activated with cocaine or show upregulated immediate early gene (IEG) expression, but D2 receptor-dependent IEG changes are intact.
Positive_regulation (upregulated) of immediate early gene associated with cocaine
19) Confidence 0.16 Published 1998 Journal Dev. Neurosci. Section Abstract Doc Link 9691193 Disease Relevance 0.07 Pain Relevance 0.59
Previous studies from this laboratory have demonstrated that acute, systemic administration of morphine results in an induction of the immediate-early gene (IEG) proteins, c-Fos and Jun-B, in the dorsomedial portion of the rat caudate-putamen (CPu).
Positive_regulation (induction) of immediate-early gene in CPu associated with morphine
20) Confidence 0.13 Published 1999 Journal Brain Res. Section Abstract Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.61

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