INT4782

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.36
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
neurons 6
thyroid gland 6
grid 2
DA neurons 2
Thyroid 2
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 374 100.00 Very High Very High Very High
midbrain 109 98.96 Very High Very High Very High
Ventral tegmentum 14 97.00 Very High Very High Very High
cytokine 3 93.72 High High
Substantia nigra 117 93.44 High High
Nucleus accumbens 7 89.76 High High
Action potential 40 89.44 High High
antagonist 14 88.40 High High
addiction 7 88.32 High High
Enkephalin 2 88.32 High High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 504 100.00 Very High Very High Very High
Disease 118 99.20 Very High Very High Very High
Graves' Ophthalmopathy 6 99.02 Very High Very High Very High
Neuroblastoma 5 99.00 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 6 98.88 Very High Very High Very High
Generalized Anxiety Disorder 1 98.56 Very High Very High Very High
Sleep Disorders 132 97.84 Very High Very High Very High
Toxicity 26 90.24 High High
Recurrence 1 86.08 High High
Anaemia 30 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that treatment with Bt2cAMP and TPA induces the expression of multiple genes of peptide hormone and tyrosine hydroxylase and increases hormone production and secretion through morphological changes into endocrine cells.
Positive_regulation (induces) of Gene_expression (expression) of tyrosine hydroxylase in endocrine cells
1) Confidence 0.47 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.14 Pain Relevance 0.26
A1 hybrid neurons also express messages for choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and glutamic acid decarboxylase (GAD), indicating that they could differentiate into various subsets of neuronal types.
Positive_regulation (messages) of Gene_expression (express) of TH in neurons associated with generalized anxiety disorder
2) Confidence 0.46 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.47 Pain Relevance 0.17
The preD protocol was used for the above experiments because of the observation that it enhanced the proportion of TH-positive neurons among the differentiated ReNcell VM neurons.
Positive_regulation (enhanced) of Gene_expression (proportion) of TH in neurons associated with midbrain
3) Confidence 0.34 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1888696 Disease Relevance 0 Pain Relevance 0.27
In contrast, after differentiation, strong TH expression was shown in the ReNcell VM neurons both by Western blot and immunocytochemical analysis (colabelling of TH and ?
Positive_regulation (strong) of Gene_expression (expression) of TH in neurons associated with midbrain
4) Confidence 0.30 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1888696 Disease Relevance 0 Pain Relevance 0.19
Parameters used for TH stereological counting were grid size, 300 ?
Positive_regulation (used) of Gene_expression (counting) of TH in grid
5) Confidence 0.23 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0 Pain Relevance 0.20
In both cases (TH and NeuN cell number), the rats that received AAV1/2-A53T ?
Positive_regulation (cases) of Gene_expression (number) of TH
6) Confidence 0.23 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.23 Pain Relevance 0.27
Furthermore, chronic exposure to drugs of abuse causes longterm adaptations in cAMP concentrations, tyrosine hydroxylase production, DA expression, receptor coupling to G proteins, and basal firing rate of VTA-DA neurons [64,65].
Positive_regulation (causes) of Gene_expression (production) of tyrosine hydroxylase in DA neurons associated with ventral tegmentum and dopamine
7) Confidence 0.06 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2958859 Disease Relevance 0.30 Pain Relevance 1.20
In Graves’ disease, the thyroid gland is dysregulated and TH levels do not follow the circadian TH rhythm of a typical normal subject.47
Neg (not) Positive_regulation (follow) of Gene_expression (levels) of TH in thyroid gland associated with graves' ophthalmopathy and disease
8) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.09 Pain Relevance 0
In Graves’ disease, the thyroid gland is dysregulated and TH levels do not follow the circadian TH rhythm of a typical normal subject.47
Positive_regulation (circadian) of Gene_expression (rhythm) of TH in thyroid gland associated with graves' ophthalmopathy and disease
9) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.09 Pain Relevance 0
In Graves’ disease, the thyroid gland is dysregulated and TH levels do not follow the circadian TH rhythm of a typical normal subject.47
Neg (not) Positive_regulation (follow) of Gene_expression (rhythm) of TH in thyroid gland associated with graves' ophthalmopathy and disease
10) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.09 Pain Relevance 0
One hormonal effect of estradiol is to increase levels of TH.42 Thus, one possible cause of higher TH levels in pregnancy is the higher levels of estradiol, which suggests that estradiol may indirectly cause symptoms of RLS by increasing TH.
Positive_regulation (increase) of Gene_expression (levels) of TH associated with restless legs syndrome
11) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.99 Pain Relevance 0.15
An additional supportive clinical feature is the “improvement of RLS symptoms with DA therapy”.1,2,7

IRON LEVELS, TYROSINE HYDROXYLASE, CYTHOCROME P450, DA AND TH

Positive_regulation (improvement) of Gene_expression (symptoms) of TH associated with dopamine and restless legs syndrome
12) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.56 Pain Relevance 0.24
In other words, the daily circadian waveform of thyrotropin could well be titled “The Thyroid Axis and Sleep”, instead of “Sleep and the Thyroid Axis”.The effects of TH are more likely to promote sleeplessness rather than sleepiness.21,22
Positive_regulation (effects) of Gene_expression (effects) of TH in Thyroid associated with sleep initiation and maintenance disorders and sleep disorders
13) Confidence 0.04 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.40 Pain Relevance 0

General Comments

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