INT4783

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Context Info
Confidence 0.11
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.28
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRL) extracellular region (GHRL) cytoplasm (GHRL)
Anatomy Link Frequency
brain 2
enterochromaffin cells 1
endocrine cells 1
stomach 1
GHRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 63 97.68 Very High Very High Very High
Enkephalin 6 86.56 High High
behavioral therapy 1 85.08 High High
substance P 3 83.64 Quite High
Inflammation 15 53.36 Quite High
agonist 4 23.12 Low Low
Central grey 14 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
orphanin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Constipation 13 93.24 High High
Recurrence 1 89.84 High High
Infection 15 88.80 High High
Functional Bowel Disorder 2 82.72 Quite High
Obesity 16 81.20 Quite High
Neuroblastoma 2 75.00 Quite High
INFLAMMATION 15 53.36 Quite High
Gastritis 6 50.00 Quite Low
Gastrointestinal Disease 1 50.00 Quite Low
Body Weight 2 27.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Motilin is a 22-amino acid peptide hormone secreted by the enterochromaffin cells of the small intestine [4,5].
Localization (secreted) of peptide hormone in enterochromaffin cells
1) Confidence 0.11 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.59 Pain Relevance 0.04
The results indicated that treatment with Bt2cAMP and TPA induces the expression of multiple genes of peptide hormone and tyrosine hydroxylase and increases hormone production and secretion through morphological changes into endocrine cells.
Localization (secretion) of peptide hormone in endocrine cells
2) Confidence 0.09 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.14 Pain Relevance 0.25
The stomach is considered an important organ for obestatin secretion because obestatin can be purified from the stomach and tends to be lower in gastrectomy patients (16).
Localization (secretion) of obestatin in stomach
3) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.55 Pain Relevance 0.03
Finally, in order to validate the computational methodology, we present the basic molecular biological characterization of the novel putative peptide hormone, including its identification and regional localization in the brain.
Localization (localization) of peptide hormone in brain
4) Confidence 0.01 Published 2009 Journal PLoS Computational Biology Section Abstract Doc Link PMC2603333 Disease Relevance 0 Pain Relevance 0.12
This novel putative peptide hormone is found in discreet brain regions as well as other organs.
Localization (found) of peptide hormone in brain
5) Confidence 0.01 Published 2009 Journal PLoS Computational Biology Section Abstract Doc Link PMC2603333 Disease Relevance 0 Pain Relevance 0.16

General Comments

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