INT47845

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 3.10
Pain Relevance 9.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
spinal 2
mesenteric artery 2
spinal cord dorsal horn 2
heart 2
dorsal horn 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 248 100.00 Very High Very High Very High
addiction 7 99.92 Very High Very High Very High
Glutamate 14 99.84 Very High Very High Very High
Dorsal horn 7 99.84 Very High Very High Very High
Acute pain 2 99.48 Very High Very High Very High
noradrenaline 9 99.36 Very High Very High Very High
tolerance 3 99.32 Very High Very High Very High
opiate 2 98.92 Very High Very High Very High
Morphine 10 98.64 Very High Very High Very High
Spinal cord 33 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 22 99.58 Very High Very High Very High
Pain 22 99.48 Very High Very High Very High
Nociception 41 98.76 Very High Very High Very High
Neuropathic Pain 22 98.40 Very High Very High Very High
Opiate Addiction 1 97.44 Very High Very High Very High
Injury 17 94.56 High High
Ganglion Cysts 52 90.88 High High
Hypersensitivity 2 88.92 High High
Hyperalgesia 14 81.08 Quite High
Morphine Dependence 1 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of PKC translocation and activation may prove useful for the management of pain and opiate addiction.
Regulation (Modulation) of Localization (translocation) of PKC associated with addiction, pain, kinase c and opiate
1) Confidence 0.62 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.27 Pain Relevance 1.54
In addition the difference between naloxone-precipitated and spontaneous withdrawal in vivo suggests that in postnatal day 7 rats, morphine exposure produces an early phase of primary afferent sensitization dependent upon PKC translocation, followed by a later phase involving spinal sensitization mediated by PKC gamma.
Regulation (dependent) of Localization (translocation) of PKC in spinal associated with kinase c, spinal sensitization, narcan, withdrawal and morphine
2) Confidence 0.45 Published 2004 Journal Pain Section Abstract Doc Link 15275778 Disease Relevance 0.38 Pain Relevance 1.36
The objective of the present study was to assess the influence of diabetes in the neuronal nitric oxide (NO) release elicited by electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz, for 30 s, at 1 min interval) in endothelium-denuded mesenteric artery segments from control and streptozotocin-induced diabetic rats, assessing the influence of protein kinase C (PKC) in this release.
Regulation (influence) of Localization (release) of PKC in mesenteric artery associated with kinase c and diabetes mellitus
3) Confidence 0.35 Published 2000 Journal Life Sci. Section Abstract Doc Link 10665985 Disease Relevance 0.47 Pain Relevance 0.26
Rottlerin abolished opioid-induced cardioprotection (48.9 +/- 4.8) and PKC-delta translocation without affecting the translocation of PKC-alpha, -beta(1), or -epsilon.
Neg (without) Regulation (affecting) of Localization (translocation) of PKC associated with kinase c and opioid
4) Confidence 0.31 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179083 Disease Relevance 0.05 Pain Relevance 0.94
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Regulation (detected) of Localization (translocation) of PKC
5) Confidence 0.31 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
Finally, we demonstrate that genistein did not affect protein kinase C (PKC) translocation induced by TAN-67.
Regulation (affect) of Localization (translocation) of PKC associated with kinase c
6) Confidence 0.27 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602657 Disease Relevance 0.11 Pain Relevance 0.56
The effects of agents that modulate intracellular release of calcium and protein kinase C (PKC) activation on noradrenaline (NA)-induced contractions of epididymal vas deferens in calcium-free/EGTA (1 mM) medium were investigated.
Regulation (modulate) of Localization (release) of PKC in vas deferens associated with kinase c and noradrenaline
7) Confidence 0.27 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416820 Disease Relevance 0 Pain Relevance 0.49
These results suggest that while NMDA, but not mGluR1/5, receptors are involved in translocation of PKC and nociception in a model of persistent acute pain, both types of receptors influence the translocation of PKC in dorsal horn and mechanical and cold allodynia in a model of chronic neuropathic pain.
Regulation (influence) of Localization (translocation) of PKC in dorsal horn associated with nociception, kinase c, allodynia, acute pain, neuropathic pain and dorsal horn
8) Confidence 0.27 Published 2001 Journal Pain Section Abstract Doc Link 11576741 Disease Relevance 0.99 Pain Relevance 0.92
Noxious stimulus-induced PKC translocation likely depends on glutamate activity at either N-methyl-D-aspartate (NMDA) receptors or group I metabotropic glutamate receptors (mGluR1/5) in the spinal cord dorsal horn.
Regulation (depends) of Localization (translocation) of PKC in spinal cord dorsal horn associated with glutamate, kinase c, glutamate receptor, dorsal horn and spinal cord
9) Confidence 0.27 Published 2001 Journal Pain Section Abstract Doc Link 11576741 Disease Relevance 0.59 Pain Relevance 0.93
Effects of picrotoxin and M1 mACh receptor activation on the translocation of PKC?
Regulation (Effects) of Localization (translocation) of PKC associated with kinase c
10) Confidence 0.18 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.41
These data suggest that a TK, but most likely not an Src/EGF receptor TK, is important in cardioprotection via opioid receptor stimulation and that the pathway for TK activation is downstream from or parallel to PKC activation in the in situ rat heart since genistein could not affect PKC translocation of selective isoforms induced by TAN-67 and assessed by immunohistochemistry.
Neg (not) Regulation (affect) of Localization (translocation) of PKC in heart associated with kinase c and opioid receptor
11) Confidence 0.16 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602657 Disease Relevance 0 Pain Relevance 0.46
Indeed, the translocation of eGFP-PKC?
Regulation (eGFP) of Localization (translocation) of PKC associated with kinase c
12) Confidence 0.15 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.69
Our observation is also in line with the finding that S800 is crucially involved in PMA-mediated sensitization of TRPV1 via PKC-?
Regulation (involved) of Localization (sensitization) of PKC
13) Confidence 0.11 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.16
PKC induced alteration of NR1 subunits is not dependent on MMP-activity
Neg (not) Regulation (dependent) of Localization (alteration) of PKC
14) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.20
Based on our results and data from others, we believe that PKC?
Regulation (results) of Localization (believe) of PKC
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.14 Pain Relevance 0.08
Cytochalasin D almost completely blocked TRPV1 current potentiation by insulin, implicating involvement of protein trafficking affecting translocation of both TRPV1 and PKC.
Regulation (affecting) of Localization (translocation) of PKC associated with kinase c
16) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1142339 Disease Relevance 0.09 Pain Relevance 0.44

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