INT47846

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Context Info
Confidence 0.33
First Reported 1995
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
paw 2
neurons 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 11 100.00 Very High Very High Very High
Morphine 6 99.10 Very High Very High Very High
Inflammation 12 98.92 Very High Very High Very High
addiction 4 97.98 Very High Very High Very High
Hyperalgesia 6 97.92 Very High Very High Very High
withdrawal 4 97.92 Very High Very High Very High
Analgesic 1 96.96 Very High Very High Very High
tolerance 3 96.62 Very High Very High Very High
intrathecal 1 94.56 High High
Spinal cord 5 92.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 98.92 Very High Very High Very High
Morphine Dependence 1 97.98 Very High Very High Very High
Hyperalgesia 7 97.92 Very High Very High Very High
Pain 1 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A defined mixture of purified gangliosides, which inhibits intracellular protein kinase C translocation and activation, decreased inflammation-induced paw withdrawal latency, and specifically decreased the activity of membrane-associated protein kinase Cbetall on the side of the spinal cord ipsilateral to the inflammation.
Negative_regulation (inhibits) of Localization (translocation) of protein kinase in paw associated with kinase c, inflammation, withdrawal and spinal cord
1) Confidence 0.33 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.03 Pain Relevance 1.30
The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons.
Negative_regulation (block) of Localization (translocation) of protein kinase in neurons associated with addiction, kinase c, analgesic, tolerance and morphine
2) Confidence 0.12 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.10 Pain Relevance 1.45

General Comments

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