INT47847

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.02
Pain Relevance 12.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
plasma 4
spinal 2
sciatic nerve 2
neurons 2
hippocampus 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 238 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
antagonist 15 99.96 Very High Very High Very High
spinal dorsal horn 1 99.84 Very High Very High Very High
Hyperalgesia 5 99.82 Very High Very High Very High
Ultiva 11 99.40 Very High Very High Very High
sSRI 1 99.24 Very High Very High Very High
Hippocampus 6 99.14 Very High Very High Very High
Thermal hyperalgesia 5 99.12 Very High Very High Very High
Morphine 8 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 10 99.82 Very High Very High Very High
Adult Respiratory Distress Syndrome 13 99.22 Very High Very High Very High
Morphine Dependence 1 97.98 Very High Very High Very High
Pain 9 97.64 Very High Very High Very High
Nervous System Injury 12 97.44 Very High Very High Very High
Pressure And Volume Under Development 7 97.40 Very High Very High Very High
Nociception 2 96.02 Very High Very High Very High
Post Operative Pain 2 94.84 High High
Lung Injury 2 91.44 High High
Sepsis 2 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitors of intracellular PKC translocation and activation block thermal hyperalgesia and spontaneous pain behaviors after CCI and also reduce the elevated spinal cord neural activity in CCI rats.
Negative_regulation (Inhibitors) of Localization (translocation) of PKC in neural associated with pain, thermal hyperalgesia, spontaneous pain and spinal cord
1) Confidence 0.58 Published 1995 Journal NIDA Res. Monogr. Section Abstract Doc Link 8742791 Disease Relevance 1.07 Pain Relevance 1.82
Fluoxetine, a selective serotonin uptake inhibitor (SSRI) and ketanserin a 5-HT2A antagonist, attenuated PKC translocation by MDMA with differing efficacies; however, both compounds completely prevented the loss of 5-HT uptake sties after multiple doses of MDMA.
Negative_regulation (attenuated) of Localization (translocation) of PKC associated with kinase c, antagonist, ssri, serotonin and fluoxetine
2) Confidence 0.43 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9272479 Disease Relevance 0 Pain Relevance 0.82
Systemic lidocaine inhibits remifentanil-induced hyperalgesia via the inhibition of cPKCgamma membrane translocation in spinal dorsal horn of rats.
Negative_regulation (inhibition) of Localization (translocation) of cPKCgamma in spinal associated with anesthesia, hyperalgesia, spinal dorsal horn, ultiva and lidocaine
3) Confidence 0.43 Published 2009 Journal J Neurosurg Anesthesiol Section Title Doc Link 19955894 Disease Relevance 0.49 Pain Relevance 2.03
Both three-dimensional increases in spinal cord membrane-bound PKC and nociceptive behaviors (thermal hyperalgesia and spontaneous pain behaviors) in CCI rats were reliably reduced after three daily intrathecal treatments with 80 nmol GM1 ganglioside (a glycosphingolipid shown to prevent PKC translocation/activation), the first of which was given 1 h after sciatic nerve ligation.
Negative_regulation (prevent) of Localization (translocation/activation) of PKC in sciatic nerve associated with pain, nociception, spinal cord, kinase c, nervous system injury, thermal hyperalgesia, spontaneous pain, sciatic nerve and intrathecal
4) Confidence 0.43 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8410149 Disease Relevance 1.17 Pain Relevance 1.50
The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons.
Negative_regulation (block) of Localization (translocation) of PKC in neurons associated with addiction, kinase c, analgesic, tolerance and morphine
5) Confidence 0.43 Published 1995 Journal Pain Section Abstract Doc Link 7478679 Disease Relevance 0.10 Pain Relevance 1.45
This sensitizing action of PKC activators on peptide release was significantly reduced by PKC down-regulation or by pretreating cultures with 10 nM staurosporine.
Negative_regulation (reduced) of Localization (release) of PKC associated with kinase c
6) Confidence 0.42 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8667028 Disease Relevance 0 Pain Relevance 0.95
PKC translocation was abolished by chelerythrine and BNTX in TAN-67-treated rats.
Negative_regulation (abolished) of Localization (translocation) of PKC associated with kinase c
7) Confidence 0.40 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179083 Disease Relevance 0.18 Pain Relevance 0.99
Rottlerin abolished opioid-induced cardioprotection (48.9 +/- 4.8) and PKC-delta translocation without affecting the translocation of PKC-alpha, -beta(1), or -epsilon.
Negative_regulation (abolished) of Localization (translocation) of PKC associated with kinase c and opioid
8) Confidence 0.40 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179083 Disease Relevance 0.11 Pain Relevance 1.00
Treatment with the anticonvulsant midazolam (0.5 mg/kg) 10 min postsarin exposure markedly reduced zeta-PKC immunoreactivity level and betaII-PKC in the membrane fractions in the hippocampus. betaII-PKC peptide (380 ng/kg), known to inhibit PKC translocation and activation, attenuated sarin-induced neuropathology.
Negative_regulation (inhibit) of Localization (translocation) of PKC in hippocampus associated with kinase c, versed, hippocampus and anticonvulsant
9) Confidence 0.39 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15716382 Disease Relevance 0.28 Pain Relevance 0.84
In ALI induced by ET-1, we noticed a reduced trend towards translocation and activation of PKC?
Negative_regulation (trend) of Localization (translocation) of PKC associated with adult respiratory distress syndrome
10) Confidence 0.20 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.64 Pain Relevance 0.03
eGFP-PKC translocation was determined as a decrease in the cytosolic fluorescence as eGFP-PKC localized to the plasma membrane (Bartlett et al. 2005).


Negative_regulation (decrease) of Localization (translocation) of PKC in plasma associated with kinase c
11) Confidence 0.17 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.46
eGFP-PKC translocation was determined as a decrease in the cytosolic fluorescence as eGFP-PKC localized to the plasma membrane (Bartlett et al. 2005).


Negative_regulation (decrease) of Localization (localized) of PKC in plasma associated with kinase c
12) Confidence 0.15 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.47

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