INT47848

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.78
Pain Relevance 7.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
cingulate cortex 4
spinal 2
laminas 2
dorsal horn 2
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 38 100.00 Very High Very High Very High
fortral 9 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Analgesic 7 99.10 Very High Very High Very High
antagonist 11 98.86 Very High Very High Very High
Dextromethorphan 13 98.84 Very High Very High Very High
opiate 2 98.68 Very High Very High Very High
Spinal cord 9 98.40 Very High Very High Very High
spinal dorsal horn 3 98.12 Very High Very High Very High
tolerance 4 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 100.00 Very High Very High Very High
Nociception 13 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Stress 6 99.16 Very High Very High Very High
Urological Neuroanatomy 1 94.60 High High
Pain 7 93.28 High High
Fever 1 82.40 Quite High
Neuropathic Pain 1 81.24 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 79.88 Quite High
Cancer 8 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with dextromethorphan at 60 mg/kg s.c., 30 min prior to formalin resulted in a suppression of c-fos induction, so that c-fos mRNA levels in the ipsilateral spinal dorsal horn of animals receiving dextromethorphan prior to formalin did not differ from controls.
Negative_regulation (suppression) of Positive_regulation (induction) of c-fos in dorsal horn associated with spinal dorsal horn and dextromethorphan
1) Confidence 0.57 Published 1995 Journal Pain Section Abstract Doc Link 7478683 Disease Relevance 0.33 Pain Relevance 0.53
Administration of RTX blocked both inflammation-induced hyperalgesia and spinal c-Fos induction.
Negative_regulation (blocked) of Positive_regulation (induction) of c-Fos in spinal associated with hyperalgesia and inflammation
2) Confidence 0.57 Published 2003 Journal Pain Section Abstract Doc Link 12855332 Disease Relevance 0.90 Pain Relevance 0.82
Rimcazole failed to inhibit pentazocine c-fos induction.
Negative_regulation (inhibit) of Positive_regulation (induction) of c-fos associated with fortral
3) Confidence 0.57 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.06 Pain Relevance 0.47
Rimcazole inhibited PCP c-fos induction in the cingulate and parietal cortices and DTG c-fos induction in the cingulate cortex.
Negative_regulation (inhibited) of Positive_regulation (induction) of c-fos in cingulate cortex
4) Confidence 0.57 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.07 Pain Relevance 0.48
Potentiation by metamizol was also observed as a bilateral decrease in stimulus-evoked c-Fos induction in superficial laminas (I-II) of the dorsal spinal cord after drug combination compared to single administration (66.5 +/- 2.2 vs. 80.7 +/- 4.2; P < 0.05).
Negative_regulation (decrease) of Positive_regulation (induction) of c-Fos in laminas associated with spinal cord
5) Confidence 0.57 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698203 Disease Relevance 0.07 Pain Relevance 1.18
The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in the deep laminae by NK2 antagonism. c-Fos induction was reduced in all laminae by both NK1 and NK2 antagonism but less than with c-Jun.
Negative_regulation (reduced) of Positive_regulation (induction) of c-Fos associated with c fibre and antagonist
6) Confidence 0.41 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657480 Disease Relevance 0 Pain Relevance 0.28
Both the phosphorylation of MAP kinase and the induction of c-Fos were detected by immunoblotting.
Negative_regulation (detected) of Positive_regulation (induction) of c-Fos
7) Confidence 0.41 Published 1999 Journal Anesthesiology Section Body Doc Link 10598624 Disease Relevance 0 Pain Relevance 0
Rimcazole inhibited PCP c-fos induction in the cingulate and parietal cortices and DTG c-fos induction in the cingulate cortex.
Negative_regulation (inhibited) of Positive_regulation (induction) of c-fos in cingulate cortex
8) Confidence 0.41 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.07 Pain Relevance 0.47
Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models.
Negative_regulation (prevents) of Positive_regulation (activation) of c-fos associated with nociception, analgesic, tolerance, dextromethorphan and opiate
9) Confidence 0.41 Published 1995 Journal Neurology Section Abstract Doc Link 8545027 Disease Relevance 0.25 Pain Relevance 0.98
Dextromethorphan has analgesic efficacy in the experimental formalin test, blocks the nociceptive activation of the immediate-early gene, c-fos proto-oncogene, and prevents and reverses the development of opiate analgesic tolerance in experimental models.
Negative_regulation (blocks) of Positive_regulation (activation) of c-fos associated with nociception, analgesic, tolerance, dextromethorphan and opiate
10) Confidence 0.41 Published 1995 Journal Neurology Section Abstract Doc Link 8545027 Disease Relevance 0.25 Pain Relevance 0.97
Treatment of OC-14 cells with indomethacin inhibited constitutive increases in AP-1 DNA-binding activity and c-Fos/c-Jun-immunoreactive protein levels.
Negative_regulation (inhibited) of Positive_regulation (increases) of AP-1
11) Confidence 0.21 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11309312 Disease Relevance 0.65 Pain Relevance 0.05
Innocuous CRD-induced Fos was attenuated by 36% following 100 nmol MK-801.
Negative_regulation (attenuated) of Positive_regulation (induced) of Fos
12) Confidence 0.09 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123698 Disease Relevance 0 Pain Relevance 0.46
MK-801 dose-dependently attenuated noxious CRD-induced Fos.
Negative_regulation (attenuated) of Positive_regulation (induced) of Fos
13) Confidence 0.09 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123698 Disease Relevance 0 Pain Relevance 0.44
These flavonols inhibit the phosphorylation and activation of Jun N-terminal kinase/stress-activated protein kinase, leading to the suppression of AP-1 activation.
Negative_regulation (suppression) of Positive_regulation (activation) of AP-1 associated with stress
14) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.99 Pain Relevance 0.50

General Comments

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