INT4785

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.47
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PAM) lyase activity (PAM) extracellular region (PAM)
Anatomy Link Frequency
alveolar macrophages 1
tubules 1
PAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 2 98.28 Very High Very High Very High
Enkephalin 4 97.60 Very High Very High Very High
cryotherapy 9 95.60 Very High Very High Very High
Neuropeptide 2 86.80 High High
substance P 1 84.24 Quite High
cytokine 48 76.96 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
topical agent 11 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 35 100.00 Very High Very High Very High
Cancer 115 99.76 Very High Very High Very High
Fever 24 99.74 Very High Very High Very High
Melanoma 35 98.32 Very High Very High Very High
Mycobacterial Infection 54 97.32 Very High Very High Very High
Metastasis 9 94.80 High High
Syndrome 2 91.76 High High
Vipoma 1 91.40 High High
Neuroblastoma 2 89.36 High High
Toxicity 31 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pancreatic and jejunal tumors showed all structural and secretory patterns of epithelial endocrine tumors, including expression of cytokeratin, neuroendocrine markers like neuron-specific enolase, chromogranins and synaptophysin, peptides like VIP, PHM, GRH, PP, insulin, neurotensin, glucagon, somatostatin and enkephalin, secretory granules, small clear vesicles, peculiar osmiophilic bodies, and occasional formation of tubules or microacini with specialized luminal surfaces.
Gene_expression (expression) of PHM in tubules associated with cancer, somatostatin and enkephalin
1) Confidence 0.58 Published 1988 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2839087 Disease Relevance 0.93 Pain Relevance 0.24
The PAM produces a cumulative score, which is a proxy measure of total daily (24 h) physical activity.
Gene_expression (produces) of PAM
2) Confidence 0.58 Published 2005 Journal BMC Public Health Section Body Doc Link PMC1351198 Disease Relevance 0 Pain Relevance 0
In this study, topical MMC was used as primary therapy in 8 patients with PAM with atypia, in 2 patients with invasive melanoma, and in 6 patients as adjunctive therapy following surgical excision for conjunctival melanoma.
Gene_expression (therapy) of PAM associated with melanoma and freckles
3) Confidence 0.48 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694026 Disease Relevance 0.93 Pain Relevance 0.05
The presence of messenger RNAs (mRNAs) of vasoactive intestinal peptide (VIP)/peptide histidine methionine (PHM), preprotachykinin, and tyrosine hydroxylase was detectable in the cytoplasm of cultured NB-1 cells by in situ hybridization.
Gene_expression (detectable) of PHM
4) Confidence 0.36 Published 1992 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 1279891 Disease Relevance 0.16 Pain Relevance 0.25
Comparing the Wieberdink grade between G-C (true HT plus double L-PAM bolus and G-B (true HT with standard L-PAM dose) pointed out a higher increase of grade III vs grade II in G-C group.
Gene_expression (bolus) of L-PAM associated with fever
5) Confidence 0.04 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2602991 Disease Relevance 1.12 Pain Relevance 0
Corresponding with the reduced surface and mRNA expression of TLR2, Pam3Cys induced lower production of TNF-?
Gene_expression (expression) of Pam3Cys
6) Confidence 0.00 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2817655 Disease Relevance 0.18 Pain Relevance 0.10
Following the 30-minute-exposure to Pam3Cys, TLR2 expression levels on alveolar macrophages remained unchanged, whereas on monocytes it was decreased below constitutive (culture medium) levels in all the individuals tested (Figure 4A).
Gene_expression (expression) of Pam3Cys in alveolar macrophages
7) Confidence 0.00 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.16 Pain Relevance 0

General Comments

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