INT47857

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 1.67
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
vasculature 4
lumen 4
colon 2
spinal cord 2
sympathetic 2
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 6 99.98 Very High Very High Very High
agonist 16 99.28 Very High Very High Very High
Cholecystokinin 6 99.20 Very High Very High Very High
Spinal cord 8 99.08 Very High Very High Very High
qutenza 1 95.92 Very High Very High Very High
antagonist 1 91.60 High High
Clonidine 3 84.52 Quite High
abdominal pain 2 77.44 Quite High
anesthesia 3 46.16 Quite Low
Inflammation 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Frailty 8 99.22 Very High Very High Very High
Pancreatitis 4 96.60 Very High Very High Very High
Congenital Anomalies 2 91.68 High High
Diarrhoea 2 89.44 High High
Cryptosporidiosis 3 87.12 High High
Constipation 2 79.32 Quite High
Ileus 2 78.60 Quite High
Abdominal Pain 2 77.44 Quite High
Gastrointestinal Disease 2 76.44 Quite High
Injury 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urethane anaesthesia did not reduce PYY release induced by the intraduodenal meal.
Neg (not) Negative_regulation (reduce) of Localization (release) of PYY
1) Confidence 0.59 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Postprandial PYY release was suppressed or strongly decreased by caecocolonectomy, truncal vagotomy, tetrodotoxin, hexamethonium, sensory denervation by perivagal capsaicin, and by the NO-synthase inhibitor L-N-arginine methyl ester, while atropine, adrenergic blockers, antagonists of type-A or type-B cholecystokinin (CCK) receptors or bombesin receptors had no effect.
Negative_regulation (decreased) of Localization (release) of PYY associated with tetrodotoxin, qutenza, antagonist and cholecystokinin
2) Confidence 0.55 Published 1997 Journal Pflugers Arch. Section Abstract Doc Link 9049141 Disease Relevance 0 Pain Relevance 0.33
General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.
Negative_regulation (decreased) of Localization (secretions) of PYY
3) Confidence 0.38 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.13
General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.
Negative_regulation (abolished) of Localization (secretions) of PYY
4) Confidence 0.38 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.13
Additionally, GLP-1 and PYY secretions are positively modulated by alpha1-receptor stimulation and inhibited by alpha2-receptor activation upon beta-receptor occupation.
Negative_regulation (inhibited) of Localization (secretions) of PYY
5) Confidence 0.38 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.23
Hexamethonium suppressed PYY release induced by the intraduodenal meal, but did not change PYY release induced by glucose or oleic acid in the colon.
Negative_regulation (suppressed) of Localization (release) of PYY in colon
6) Confidence 0.38 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Carbachol-induced release of PYY into both lumen and vasculature was completely blocked by atropine, but not by hexamethonium.
Negative_regulation (blocked) of Localization (release) of PYY in lumen
7) Confidence 0.38 Published 1995 Journal Peptides Section Abstract Doc Link 7479339 Disease Relevance 0 Pain Relevance 0.10
Tetrodotoxin abolished carbachol-induced release of PYY into lumen and vasculature.
Negative_regulation (abolished) of Localization (release) of PYY in vasculature associated with tetrodotoxin
8) Confidence 0.38 Published 1995 Journal Peptides Section Abstract Doc Link 7479339 Disease Relevance 0 Pain Relevance 0.10
Peptide YY (PYY) is a powerful inhibitor of intestinal secretion mediated by cAMP agonists such as vasoactive intestinal peptide and prostaglandin E2.
Negative_regulation (inhibitor) of Localization (secretion) of PYY associated with agonist
9) Confidence 0.36 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353387 Disease Relevance 0.25 Pain Relevance 0.11
Peptide YY (PYY), a known inhibitor of both pancreatic secretion and the release of cholecystokinin (CCK), may play a role in the pathophysiology of acute pancreatitis (AP).
Negative_regulation (inhibitor) of Localization (secretion) of PYY associated with pancreatitis and cholecystokinin
10) Confidence 0.34 Published 1993 Journal Am. J. Surg. Section Abstract Doc Link 7685154 Disease Relevance 0.49 Pain Relevance 0.14
Tetrodotoxin abolished carbachol-induced release of PYY into lumen and vasculature.
Negative_regulation (abolished) of in lumen Localization (release) of PYY in vasculature associated with tetrodotoxin
11) Confidence 0.13 Published 1995 Journal Peptides Section Abstract Doc Link 7479339 Disease Relevance 0 Pain Relevance 0.10
Carbachol-induced release of PYY into both lumen and vasculature was completely blocked by atropine, but not by hexamethonium.
Negative_regulation (blocked) of in vasculature Localization (release) of PYY in lumen
12) Confidence 0.13 Published 1995 Journal Peptides Section Abstract Doc Link 7479339 Disease Relevance 0 Pain Relevance 0.10
Fasting peptide YY levels were not increased in spinal cord injury patients, which did not support tonic inhibition of peptide YY release.
Negative_regulation (inhibition) of Localization (release) of peptide YY in spinal cord associated with spinal cord
13) Confidence 0.03 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.29 Pain Relevance 0.11
We hypothesized that abdominal sympathetic pathways provide tonic inhibition of peptide YY and motilin release and that postprandial increases in these gut hormones are mediated through spinal pathways.
Negative_regulation (inhibition) of Localization (release) of peptide YY in sympathetic
14) Confidence 0.02 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.64 Pain Relevance 0.20

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