INT47859

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 16.92
Pain Relevance 21.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 4
PSC 1
Brain 1
kidney 1
olfactory mucosa 1
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 298 100.00 Very High Very High Very High
alcohol 30 99.68 Very High Very High Very High
withdrawal 2 98.08 Very High Very High Very High
fibrosis 18 97.76 Very High Very High Very High
Analgesic 6 97.76 Very High Very High Very High
Inflammation 29 94.48 High High
Chronic pancreatitis 1 80.80 Quite High
agonist 11 72.80 Quite High
fluoxetine 1 70.96 Quite High
tolerance 9 34.96 Quite Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 68 99.92 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 38 99.76 Very High Very High Very High
Toxicity 36 99.74 Very High Very High Very High
Fatty Liver 71 99.58 Very High Very High Very High
Body Weight 7 98.96 Very High Very High Very High
Injury 30 98.72 Very High Very High Very High
Nephrotoxicity 8 98.66 Very High Very High Very High
Overdose 9 98.40 Very High Very High Very High
Shock 3 98.00 Very High Very High Very High
Fibrosis 15 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Covalent binding has recently been detected by Western blot to a 50-kDa microsomal protein that comigrated with CYP2E1 and was accompanied by a loss of the CYP2E1 activity.
Negative_regulation (loss) of CYP2E1
1) Confidence 0.59 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9492391 Disease Relevance 0.18 Pain Relevance 0.51
Brain CYP2E1 inhibition by DDC in C57Bl mice was responsible for increased toxicity and striatal MPP(+) accumulation.
Negative_regulation (inhibition) of CYP2E1 in Brain associated with toxicity
2) Confidence 0.59 Published 2008 Journal Parkinsonism Relat. Disord. Section Abstract Doc Link 18583171 Disease Relevance 0.73 Pain Relevance 0.08
The pretreatment regimen resulted in hepatic changes including: centrilobular localization of 3-(cysteine-S-yl)APAP protein adducts, selective down-regulation of cytochrome P4502E1 (CYP2E1) and CYP1A2 that produced the toxic metabolite, N-acetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, and a fourfold increase in hepatocellular proliferation.
Negative_regulation (down-regulation) of cytochrome P4502E1 associated with paracetamol and inflammation
3) Confidence 0.59 Published 1999 Journal Hepatology Section Abstract Doc Link 9918922 Disease Relevance 0.26 Pain Relevance 0.92
The pretreatment regimen resulted in hepatic changes including: centrilobular localization of 3-(cysteine-S-yl)APAP protein adducts, selective down-regulation of cytochrome P4502E1 (CYP2E1) and CYP1A2 that produced the toxic metabolite, N-acetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, and a fourfold increase in hepatocellular proliferation.
Negative_regulation (down-regulation) of CYP2E1 associated with paracetamol and inflammation
4) Confidence 0.59 Published 1999 Journal Hepatology Section Abstract Doc Link 9918922 Disease Relevance 0.26 Pain Relevance 0.92
Oral treatment of mice with BA resulted in a significant decrease in AP-induced CYP2E1 activity together with its inhibition of AP-induced CYP2EI expression.
Negative_regulation (decrease) of CYP2E1 associated with paracetamol
5) Confidence 0.59 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.23 Pain Relevance 1.01
S-allylmercaptocysteine significantly suppressed hepatic cytochrome P450 2E1 (CYP2E1) activity and induction of inducible 70-kDa heat shock protein, a marker of acetaminophen arylation of protein.
Negative_regulation (suppressed) of CYP2E1 associated with paracetamol and shock
6) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11755151 Disease Relevance 0.44 Pain Relevance 0.76
S-allylmercaptocysteine significantly suppressed hepatic cytochrome P450 2E1 (CYP2E1) activity and induction of inducible 70-kDa heat shock protein, a marker of acetaminophen arylation of protein.
Negative_regulation (suppressed) of hepatic cytochrome P450 2E1 associated with paracetamol and shock
7) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11755151 Disease Relevance 0.44 Pain Relevance 0.76
These results suggest that S-allylmercaptocysteine exerts its protective effect by inhibition of CYP2E1 activity, which leads to the suppression of acetaminophen arylation of hepatic protein.
Negative_regulation (inhibition) of CYP2E1 associated with paracetamol
8) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11755151 Disease Relevance 0.41 Pain Relevance 0.72
TAO treatment in vivo resulted in inhibition of microsomal CYP3A-catalyzed activity, measured in vitro, with no inhibition of CYP1A2 and CYP2E1 activities.
Negative_regulation (inhibition) of CYP2E1
9) Confidence 0.59 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17392391 Disease Relevance 0.34 Pain Relevance 0.82
At the time of APAP administration, which followed an 11 h withdrawal from the alcohols, alcohol-induced levels of CYP3A were sustained in both mouse lines, whereas CYP2E1 was decreased to constitutive levels in wild-type mice.
Negative_regulation (decreased) of CYP2E1 associated with paracetamol, withdrawal and alcohol
10) Confidence 0.59 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17392391 Disease Relevance 0.44 Pain Relevance 1.05
Taurine treatment both pre and post (150 mg/kg body weight for 3 days, orally) to APAP exposure, however, significantly reduced APAP-induced nephrotoxicity through its antioxidant properties, urinary excretion of APAP and suppression of CYP2E1.
Negative_regulation (suppression) of CYP2E1 in body associated with nephrotoxicity, paracetamol and body weight
11) Confidence 0.58 Published 2010 Journal Toxicology Section Abstract Doc Link 20067817 Disease Relevance 0.36 Pain Relevance 0.84
Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition.
Negative_regulation (inhibition) of Cytochrome P4502E1 associated with paracetamol and hepatotoxicity
12) Confidence 0.58 Published 1995 Journal Pharmacol. Toxicol. Section Title Doc Link 7479582 Disease Relevance 0.32 Pain Relevance 0.51
To determine the relative contributions of these P450's, overnight fasted male NMRI mice were pretreated with 10 ml of 50% v/w propylene glycol/kg or fluvoxamine (10 mg/kg) at -80 and -20 min. relative to acetaminophen dosing to inhibit CYP2E1 and CYP1A2, respectively.
Negative_regulation (inhibit) of CYP2E1 associated with paracetamol
13) Confidence 0.58 Published 1995 Journal Pharmacol. Toxicol. Section Abstract Doc Link 7479582 Disease Relevance 0.31 Pain Relevance 0.51
In this study we wished to evaluate whether chlormethiazole, an inhibitor of CYP2E1, could prevent acetaminophen-induced liver injury in mice.
Negative_regulation (inhibitor) of CYP2E1 in liver associated with paracetamol and injury
14) Confidence 0.58 Published 1999 Journal Korean J. Intern. Med. Section Abstract Doc Link 10461422 Disease Relevance 0.25 Pain Relevance 0.26
Recently, chlormethiazole a sedative drug, is reported to be an efficient inhibitor of CYP2E1 activity in human beings.
Negative_regulation (inhibitor) of CYP2E1
15) Confidence 0.58 Published 1999 Journal Korean J. Intern. Med. Section Abstract Doc Link 10461422 Disease Relevance 0.16 Pain Relevance 0.25
In acetone-pretreated mice, the 150 and 400 mg/kg APAP doses caused similar depletion of CYP2E1 activity and similar levels of covalent binding of APAP to liver proteins.
Negative_regulation (depletion) of CYP2E1 in liver associated with paracetamol
16) Confidence 0.58 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.17 Pain Relevance 0.93
Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity.
Negative_regulation (Loss) of CYP2E1 associated with toxicity and paracetamol
17) Confidence 0.58 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8074700 Disease Relevance 0.18 Pain Relevance 0.87
Immunohistochemical staining with the cytochrome P450 CYP2E1 antibody revealed that Phyllanthus urinaria extract reduced the cytochrome P450 CYP2E1 protein level in mice pre-treated with a lethal dose of acetaminophen.
Negative_regulation (reduced) of P450 CYP2E1 associated with paracetamol
18) Confidence 0.57 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19386480 Disease Relevance 0.48 Pain Relevance 0.55
We conclude that Phyllanthus urinaria extract is effective in attenuating the acetaminophen induced hepatotoxicity, and inhibition of cytochrome P450 CYP2E1 enzyme may be an important factor for its therapeutic mechanism.
Negative_regulation (inhibition) of P450 CYP2E1 associated with paracetamol and hepatotoxicity
19) Confidence 0.57 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19386480 Disease Relevance 0.46 Pain Relevance 0.43
Phyllanthus urinaria extract also inhibited the cytochrome P450 CYP2E1 enzymatic activity in vitro.
Negative_regulation (inhibited) of P450 CYP2E1
20) Confidence 0.57 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19386480 Disease Relevance 0.45 Pain Relevance 0.54

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