INT47876

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 20
Total Number 23
Disease Relevance 4.99
Pain Relevance 20.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
ileum 1
spinal cord 1
brains 1
nervous system 1
cortex 1
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 172 100.00 Very High Very High Very High
opioid receptor 40 100.00 Very High Very High Very High
Opioid 34 100.00 Very High Very High Very High
agonist 13 100.00 Very High Very High Very High
Hyperalgesia 16 99.98 Very High Very High Very High
Neuropeptide 7 99.98 Very High Very High Very High
narcan 13 99.92 Very High Very High Very High
potassium channel 3 99.84 Very High Very High Very High
antinociception 7 99.76 Very High Very High Very High
Analgesic 15 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 21 99.98 Very High Very High Very High
Nociception 7 99.84 Very High Very High Very High
Morphine Dependence 1 99.68 Very High Very High Very High
Neuropathic Pain 5 98.76 Very High Very High Very High
Stress 3 98.64 Very High Very High Very High
Pain 11 98.18 Very High Very High Very High
Targeted Disruption 22 97.58 Very High Very High Very High
Fever 3 90.72 High High
Hypothermia 6 89.36 High High
Tics 1 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of supraspinal nocistatin and nocistatin amide, and their interaction with nociceptin on nociceptive behavior in mice, using hotplate response times.
nociceptin Spec (examined) Binding (interaction) of associated with nociception and orphanin
1) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16384642 Disease Relevance 0.34 Pain Relevance 0.44
Retro-nociceptin methylester (retro-Noc-ME), which has an oppositely directed structure to that of nociceptin, showed weak affinity for nociceptin receptor and antagonized nociceptin-induced inhibition of contraction in a guinea pig ileum (GPI) assay.
nociceptin Binding (affinity) of in ileum associated with orphanin
2) Confidence 0.46 Published 2000 Journal Life Sci. Section Abstract Doc Link 11125846 Disease Relevance 0 Pain Relevance 0.90
Orphanin FQ bound to its receptor in a saturable manner and with high affinity.
Orphanin FQ Binding (bound) of associated with orphanin
3) Confidence 0.44 Published 1995 Journal Science Section Abstract Doc Link 7481766 Disease Relevance 0.08 Pain Relevance 0.83
The opioid peptide nociceptin (orphanin FQ) suppresses drug reward, drug self-administration, and impedes some of the processes believed to underlie the transition to addiction.
orphanin FQ Binding (impedes) of associated with addiction, orphanin and opioid
4) Confidence 0.37 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17522627 Disease Relevance 0.13 Pain Relevance 0.74
The opioid peptide nociceptin (orphanin FQ) suppresses drug reward, drug self-administration, and impedes some of the processes believed to underlie the transition to addiction.
opioid peptide nociceptin Binding (impedes) of associated with addiction, orphanin and opioid
5) Confidence 0.37 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17522627 Disease Relevance 0.13 Pain Relevance 0.74
Reports indicate that OFQ/N can block the antinociception induced by mu-, delta- and kappa-opioid agonists in the rat and in the mouse, indicating that there is a functional interaction between opioid receptors and OFQ/N receptors in the nervous system.
OFQ/N Binding (interaction) of in nervous system associated with antinociception, mu agonist and opioid receptor
6) Confidence 0.36 Published 2001 Journal Brain Res. Section Abstract Doc Link 11406123 Disease Relevance 0.37 Pain Relevance 0.77
The neuropeptide orphanin FQ/nociceptin (OFQ/N) has been shown to counteract several effects of endogenous and exogenous opioids, and it has been proposed as an opioid-modulating agent involved in the development of morphine tolerance and dependence.
orphanin FQ Binding (counteract) of associated with addiction, orphanin, tolerance, neuropeptide, opioid and morphine
7) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16595734 Disease Relevance 0.06 Pain Relevance 1.05
Although nocistatin does not bind to the nociceptin receptor, it binds to the membrane of mouse brain and of spinal cord with high affinity.
nociceptin Neg (not) Binding (bind) of in spinal cord associated with orphanin and spinal cord
8) Confidence 0.33 Published 1998 Journal Nature Section Abstract Doc Link 9521323 Disease Relevance 0.96 Pain Relevance 1.53
Pharmacological characterization of orphanin FQ/nociceptin and its fragments.
orphanin FQ Binding (characterization) of associated with analgesic and orphanin
9) Confidence 0.33 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9262352 Disease Relevance 0.23 Pain Relevance 1.50
Thus, both kappa and orphanin FQ receptors readily couple to potassium channels, but the highly selective activation by dynorphin and orphanin FQ is consistent with distinct functional pathways in vivo.
orphanin FQ Binding (couple) of associated with dynorphin, orphanin and potassium channel
10) Confidence 0.33 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8794880 Disease Relevance 0 Pain Relevance 0.93
No subadditivity was observed with coadministration of the micro-agonist DAMGO, suggesting a functional interaction between OFQ and delta-opioid central pathways regulating colonic transit.
OFQ Binding (interaction) of associated with agonist and opioid
11) Confidence 0.31 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 9886987 Disease Relevance 0 Pain Relevance 0.64
Nociceptin (NC) and some of its fragments as well as nociceptin-(1-13)-peptide amide [NC- (1-13)-NH2] and a series of its analogues were prepared and tested in the mouse vas deferens in an attempt to identify the sequences involved in the activation (message) and in the binding (address) of nociceptin to its receptor.
nociceptin Binding (binding) of in vas deferens associated with orphanin
12) Confidence 0.30 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9191955 Disease Relevance 0.08 Pain Relevance 0.76
The present study was designed to examine specific interactions of OFQ with antinociception mediated by each receptor type.
OFQ Binding (interactions) of associated with antinociception
13) Confidence 0.30 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.25 Pain Relevance 1.33
OFQ competed with [3H]diprenorphine binding to mu-, delta- or kappa-opioid receptors stably expressed in Chinese hamster ovary cell lines with IC50 values of 2.1 +/- 0.4, 2.2 +/- 0.3, 0.75 +/- 0.3 microM, respectively.
OFQ Binding (binding) of in ovary associated with kappa opioid receptor
14) Confidence 0.30 Published 1997 Journal Brain Res. Section Abstract Doc Link 9406961 Disease Relevance 0 Pain Relevance 0.56
Experiments on the cultured cells transfected with the nociceptin receptor cDNA showed that NalBzoH competed with [3H]nociceptin binding and attenuated the nociceptin-induced inhibition of cAMP accumulation.
nociceptin Binding (binding) of associated with orphanin
15) Confidence 0.30 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9660760 Disease Relevance 0.80 Pain Relevance 1.15
The products were [Arg14,Lys(DTPA)15]nociceptin(1-17)-NH2 and its cross-linked dimer on the basis of mass spectrometric analysis.
nociceptin Binding (cross-linked) of associated with orphanin
16) Confidence 0.29 Published 2005 Journal Peptides Section Abstract Doc Link 15949634 Disease Relevance 0.07 Pain Relevance 0.70
Human PMN express mRNA for Noci-R, its nucleotide sequence determined, and specific binding with [(125)I]-labeled nociceptin gave an apparent K(d) approximately 1.5 nM for this PMN opioid receptor.
nociceptin Spec (determined) Binding (binding) of in PMN associated with orphanin and opioid receptor
17) Confidence 0.27 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11238602 Disease Relevance 0.09 Pain Relevance 0.57
Nociceptin/orphanin FQ knockout mice show alterations in pain sensitivity and stress responses and display increased morphine dependence, suggesting an interaction of the nociceptin/orphanin FQ system with classical opioid receptor function.
orphanin FQ Binding (interaction) of associated with stress, targeted disruption, addiction, pain, orphanin, opioid receptor and morphine
18) Confidence 0.26 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605902 Disease Relevance 0.74 Pain Relevance 1.72
Hyperalgesia elicited by nociceptin was inhibited dose-dependently by i.t. co-administration of tachykinin NK1 receptor antagonists, CP-99,994 and sendide.
nociceptin Binding (elicited) of associated with hyperalgesia, antagonist and orphanin
19) Confidence 0.26 Published 1999 Journal Brain Res. Section Abstract Doc Link 10546991 Disease Relevance 0.44 Pain Relevance 0.97
In mouse brain cortex membranes, the binding of the ORL1 receptor agonist [3H]nociceptin was equipotently inhibited by Mr 2266 and its enantiomer Mr 2267 (pK(i) 4.82 and 5.14, respectively), whereas the binding of the kappa-opioid receptor agonist [3H]U-69,593 was inhibited by Mr 2266 more potently (pK(i) 9.11) than by its enantiomer Mr 2267 (pK(i)7.15).
nociceptin Binding (binding) of in cortex associated with orphanin, kappa opioid receptor, agonist and opioid
20) Confidence 0.21 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9933145 Disease Relevance 0 Pain Relevance 0.96

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