INT47885

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Context Info
Confidence 0.65
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.54
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Max) nucleus (Max) protein complex assembly (Max)
DNA binding (Max) cytoplasm (Max)
Max (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 22 100.00 Very High Very High Very High
Potency 4 100.00 Very High Very High Very High
fluoxetine 2 98.42 Very High Very High Very High
Pain 34 96.60 Very High Very High Very High
lidocaine 54 95.12 Very High Very High Very High
midbrain 4 94.32 High High
Ventral tegmentum 2 91.72 High High
Substantia nigra 2 89.60 High High
local anesthetic 50 86.24 High High
antagonist 6 85.12 High High
Disease Link Frequency Relevance Heat
Pain 36 96.60 Very High Very High Very High
Pruritus 5 56.80 Quite High
Pressure And Volume Under Development 5 56.08 Quite High
Erythema 8 54.56 Quite High
Burns 6 53.44 Quite High
Insect Bites And Stings 1 51.84 Quite High
Functional Bowel Disorder 4 50.00 Quite Low
Stress 4 50.00 Quite Low
Food Poisoning 4 50.00 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 25.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The parameters of Num, Max and Area in the PI + ACRS group were all significantly higher than those of the PI group [Max: (41 +/- 17) mm Hg vs (22 +/- 6) mm Hg, P = 0.000; Area: (7693 +/- 2822) mm Hg.s vs (5092 +/- 1687) mm Hgxs, P = 0.000; Num: 9.5 +/- 2.6 vs 6.6 +/- 3.1, P = 0.000]; so was the distension volume of AWR3 [(2.25 +/- 0.29) ml vs (2.52 +/- 0.32) ml, P = 0.004].
Gene_expression (higher) of Max
1) Confidence 0.65 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137711 Disease Relevance 0 Pain Relevance 0
The pretreatment of animals with either alpha-methyl-p-tyrosine (AMPT) or reserpine, but not p-chlorophenylalanine (PCPA), (+/-)-fluoxetine or tomoxetine, significantly attenuated the suppression of A10 DA cell firing produced by trans 4S,5S 4-MAX.
Gene_expression (produced) of MAX associated with dopamine and fluoxetine
2) Confidence 0.65 Published 1995 Journal Synapse Section Abstract Doc Link 7482294 Disease Relevance 0 Pain Relevance 0.71
LMX (ELA-Max)
Gene_expression (-) of Max
3) Confidence 0.65 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661648 Disease Relevance 0.54 Pain Relevance 0.51
The intravenous (i.v.) administration of the stereoisomers of 4-MAX (0.1-6.4 mg/kg) produced a dose-dependent suppression of the basal firing rate of A10 DA cells with the following rank order of potency: trans 4S,5S > cis 4R,5S approximately cis 4S,5R >> trans 4S,5S 4-MAX.
Gene_expression (produced) of MAX associated with dopamine and potency
4) Confidence 0.58 Published 1995 Journal Synapse Section Abstract Doc Link 7482294 Disease Relevance 0 Pain Relevance 0.62
The parameters of Num, Max and Area in the PI + ACRS group were all significantly higher than those of the PI group [Max: (41 +/- 17) mm Hg vs (22 +/- 6) mm Hg, P = 0.000; Area: (7693 +/- 2822) mm Hg.s vs (5092 +/- 1687) mm Hgxs, P = 0.000; Num: 9.5 +/- 2.6 vs 6.6 +/- 3.1, P = 0.000]; so was the distension volume of AWR3 [(2.25 +/- 0.29) ml vs (2.52 +/- 0.32) ml, P = 0.004].
Gene_expression (those) of Max
5) Confidence 0.57 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20137711 Disease Relevance 0 Pain Relevance 0

General Comments

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