INT47894

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.08
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
nerve 1
neurons 1
heart 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 47 100.00 Very High Very High Very High
agonist 7 100.00 Very High Very High Very High
intrathecal 5 100.00 Very High Very High Very High
withdrawal 7 99.96 Very High Very High Very High
Pain 6 99.92 Very High Very High Very High
nociceptor 3 99.92 Very High Very High Very High
Periaqueductal grey 5 99.78 Very High Very High Very High
Locus ceruleus 7 99.68 Very High Very High Very High
addiction 2 99.64 Very High Very High Very High
antinociception 1 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 105 100.00 Very High Very High Very High
Urological Neuroanatomy 5 99.78 Very High Very High Very High
Myocardial Infarction 2 98.56 Very High Very High Very High
Heart Rate Under Development 8 95.32 Very High Very High Very High
Contusions 18 79.00 Quite High
Depression 4 77.44 Quite High
Death 36 56.72 Quite High
Morphine Dependence 1 54.36 Quite High
Spinal Cord Injury 87 53.68 Quite High
Apoptosis 72 47.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of vascular contractile responses to alpha 1- and alpha 2-adrenergic and neuropeptide Y receptor stimulation in rats with ischaemic heart failure.
Regulation (Modulation) of neuropeptide Y receptor in heart associated with neuropeptide and myocardial infarction
1) Confidence 0.33 Published 1995 Journal Acta Physiol. Scand. Section Title Doc Link 7484169 Disease Relevance 0.65 Pain Relevance 0.28
Taken together, these data suggest that: (1) at least two neuropeptide Y receptor types are present in the rat colon autonomic nerve terminals and modulate the release of acetylcholine and possibly other transmitters; (2) a proportion of the receptors mediating the contractile response of the rat colon (especially descending part) to neuropeptide Y and related peptides appears to be of the Y2 type and (3) the significant portion of the response is mediated by a receptor which is insensitive to neuropeptide Y Y1, Y2 and to neuropeptide Y Y5 receptor antagonists.
Spec (possibly) Regulation (modulate) of neuropeptide Y receptor in nerve associated with antagonist and neuropeptide
2) Confidence 0.32 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10422644 Disease Relevance 0 Pain Relevance 1.05
As illustrated in Figure 1, the mRNAs for neuropeptide receptor (Npy1r) and growth factor (Tgfa) are slightly down-regulated at 1-week post-injury, but are then strongly down-regulated at later survival times.
Regulation (regulated) of Npy1r associated with injury and neuropeptide
3) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.59 Pain Relevance 0.05
As illustrated in Figure 1, the mRNAs for neuropeptide receptor (Npy1r) and growth factor (Tgfa) are slightly down-regulated at 1-week post-injury, but are then strongly down-regulated at later survival times.
Regulation (regulated) of Npy1r associated with injury and neuropeptide
4) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.66 Pain Relevance 0.05
The remaining 4 genes (Npy1r, Tgfa, Actb, Tgfbr1) were relatively unaffected at early times post-injury, but exhibited a significant change in expression over time.
Neg (unaffected) Regulation (unaffected) of Npy1r associated with injury
5) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.47 Pain Relevance 0.04
The results demonstrated that NPY plays an important role in antinociception in PAG, in which Y1 receptor is involved in.
Regulation (involved) of Y1 receptor associated with antinociception and periaqueductal grey
6) Confidence 0.16 Published 2000 Journal Brain Res. Section Abstract Doc Link 10719086 Disease Relevance 0.45 Pain Relevance 0.53
Although long-term adaptations of LC neurons have previously been implicated in the development of morphine tolerance, dependence, and withdrawal, alterations in the levels of TH, GAL, or NPY mRNA in the LC apparently do not underlie this process.
Regulation (alterations) of NPY mRNA in neurons associated with addiction, locus ceruleus, tolerance, withdrawal and morphine
7) Confidence 0.14 Published 1995 Journal Synapse Section Abstract Doc Link 7540319 Disease Relevance 0.05 Pain Relevance 1.53
The effect of intrathecal selective agonists of Y1 and Y2 neuropeptide Y receptors on the flexor reflex in normal and axotomized rats.
Regulation (effect) of Y1 associated with nociceptor, neuropeptide, agonist and intrathecal
8) Confidence 0.08 Published 1999 Journal Brain Res. Section Title Doc Link 10375701 Disease Relevance 0.20 Pain Relevance 0.74

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox