INT479

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 10.71
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
dentate gyrus 2
spinal cord 2
brainstem 2
frontal cortex 2
pituitary 1
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 19 99.82 Very High Very High Very High
Eae 4 99.72 Very High Very High Very High
Thermal hyperalgesia 2 99.12 Very High Very High Very High
Central nervous system 3 98.28 Very High Very High Very High
Neuropathic pain 7 98.16 Very High Very High Very High
Hippocampus 6 96.92 Very High Very High Very High
Dopamine 6 93.92 High High
Inflammatory response 18 91.56 High High
Inflammation 15 90.36 High High
antidepressant 6 89.08 High High
Disease Link Frequency Relevance Heat
Convulsion 35 99.76 Very High Very High Very High
Injury 70 99.72 Very High Very High Very High
Hyperalgesia 4 99.12 Very High Very High Very High
Disorders Of Creatine Metabolism 2 98.96 Very High Very High Very High
Natriuresis 12 98.88 Very High Very High Very High
Neuropathic Pain 7 98.16 Very High Very High Very High
Diuresis 44 97.56 Very High Very High Very High
Hypertension 12 97.24 Very High Very High Very High
Hyperglycemia 2 96.60 Very High Very High Very High
Increased Venous Pressure Under Development 6 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of GDNFR-beta in brainstem
1) Confidence 0.69 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0
While the GDNF, GDNFR-alpha and GDNFR-beta levels in the frontal cortex were increased significantly at 1, 2 and 4 h after the injection of naloxone during morphine withdrawal.
Positive_regulation (increased) of GDNFR-beta in frontal cortex
2) Confidence 0.69 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.15 Pain Relevance 0
While the GDNF, GDNFR-alpha and GDNFR-beta levels in the frontal cortex were increased significantly at 1, 2 and 4 h after the injection of naloxone during morphine withdrawal.
Positive_regulation (increased) of GDNFR-alpha in frontal cortex
3) Confidence 0.69 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.15 Pain Relevance 0
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of GDNFR-alpha in brainstem
4) Confidence 0.69 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0
A glomerular defect in prehypertensive Dahl S rats, which limits their capacity to increase GFR.
Positive_regulation (increase) of GFR
5) Confidence 0.69 Published 1989 Journal Am. J. Hypertens. Section Title Doc Link 2757812 Disease Relevance 0.18 Pain Relevance 0.08
Levels of GFRalpha-2 mRNA in the dentate gyrus were also significantly increased by acute and chronic ECS, although this effect was less than that observed for GFRalpha-1.
Positive_regulation (increased) of GFRalpha-2 in dentate gyrus associated with convulsion
6) Confidence 0.58 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.76 Pain Relevance 0.23
Maximum induction of GFRalpha-2 was 30% and 70% compared to sham in response to acute or chronic ECS, respectively.
Positive_regulation (induction) of GFRalpha-2 associated with convulsion
7) Confidence 0.58 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.80 Pain Relevance 0.25
Two hours after acute ECS, levels of GFRalpha-1 mRNA in the dentate gyrus were significantly increased.
Positive_regulation (increased) of GFRalpha-1 mRNA in dentate gyrus associated with convulsion
8) Confidence 0.58 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.67 Pain Relevance 0.09
The results showed that both the protein and mRNA levels of GDNF and GFRalpha-1 were significantly increased after CCI, while the thermal hyperalgesia of neuropathic pain rats could be significantly aggravated by antisense ODN treatment, but not by normal saline (NS) or mismatch ODN treatment.
Positive_regulation (increased) of GFRalpha-1 associated with thermal hyperalgesia, eae and neuropathic pain
9) Confidence 0.54 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.34 Pain Relevance 1.05
Hyperglycaemia enhances GFR.
Positive_regulation (enhances) of GFR
10) Confidence 0.52 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11300610 Disease Relevance 0.18 Pain Relevance 0.20
Also, increased GFR-1 in astrocytes of degenerating white matter in adult rat spinal cords after mechanical injury has been shown [2].
Positive_regulation (increased) of GFR-1 in white matter associated with injury
11) Confidence 0.49 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.68 Pain Relevance 0.20
Elevation of GFR was also 30% higher in animals receiving tertatolol.
Positive_regulation (Elevation) of GFR
12) Confidence 0.47 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2563770 Disease Relevance 0 Pain Relevance 0
However, urinary recovery of 131I-Hippuran was incomplete (66 +/- 32%), leading to a significant overestimation of GFR by 140 +/- 13% in comparison with the GFR measured by the intra-arterial technique.
Positive_regulation (overestimation) of GFR
13) Confidence 0.41 Published 1998 Journal Ren Fail Section Abstract Doc Link 9574450 Disease Relevance 0.16 Pain Relevance 0.07
Prehypertensive S rats had virtually no increase in GFR after the amino acid infusion.
Neg (no) Positive_regulation (increase) of GFR
14) Confidence 0.40 Published 1989 Journal Am. J. Hypertens. Section Abstract Doc Link 2757812 Disease Relevance 0.12 Pain Relevance 0.07
Even though both S & R rats had BPs well within the normal range, the ability to increase GFR after amino acid infusion was markedly impaired in prehypertensive S rats.
Positive_regulation (increase) of GFR
15) Confidence 0.40 Published 1989 Journal Am. J. Hypertens. Section Abstract Doc Link 2757812 Disease Relevance 0.06 Pain Relevance 0.07
Thus R rats had an 81% increase of GFR after amino acids, whereas S rats increased only 18%, a 78% lower increase, P less than .001.
Positive_regulation (increase) of GFR
16) Confidence 0.40 Published 1989 Journal Am. J. Hypertens. Section Abstract Doc Link 2757812 Disease Relevance 0.14 Pain Relevance 0.08
Significant upregulation of several growth factor receptor genes (GFRa1, Ret, Lifr) also occurred only during the initial period examined.
Positive_regulation (upregulation) of GFRa1
17) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2894843 Disease Relevance 0.68 Pain Relevance 0.22
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of GDNFR-beta in spinal cord
18) Confidence 0.24 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of GDNFR-alpha in spinal cord
19) Confidence 0.24 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0
Clonidine thus appears to increase the GFR and "filtration fraction" (FF) by a phenoxybenzamine-insensitive rise of glomerular ultrafiltration, to depress ERPF by alpha-adrenergic afferent vasoconstriction, to induce natriuresis by a tubular action not blocked by phenoxybenzamine and to exert an antivasopressin effect, either by depressing pituitary vasopressin secretion or the renal response to vasopressin.
Spec (appears) Positive_regulation (increase) of GFR in pituitary associated with natriuresis, increased venous pressure under development and clonidine
20) Confidence 0.18 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 41724 Disease Relevance 0.83 Pain Relevance 0.75

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