INT47914

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Context Info
Confidence 0.18
First Reported 1994
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.05
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
synovial fluid 1
lymphocytes 1
brain 1
Il2ra (Mus musculus)
Pain Link Frequency Relevance Heat
tricyclic antidepressant 2 99.52 Very High Very High Very High
rheumatoid arthritis 67 98.94 Very High Very High Very High
fluoxetine 2 98.94 Very High Very High Very High
methotrexate 9 98.80 Very High Very High Very High
cINOD 4 98.48 Very High Very High Very High
depression 10 97.80 Very High Very High Very High
metalloproteinase 3 87.84 High High
cytokine 26 83.76 Quite High
tolerance 2 79.84 Quite High
Arthritis 15 78.56 Quite High
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 1 99.32 Very High Very High Very High
Rheumatoid Arthritis 68 98.94 Very High Very High Very High
Depression 10 97.80 Very High Very High Very High
Brain Tumor 11 97.08 Very High Very High Very High
Cancer 163 94.60 High High
INFLAMMATION 47 83.56 Quite High
Disease 24 81.44 Quite High
Arthritis 18 78.56 Quite High
Targeted Disruption 6 63.56 Quite High
Glioblastoma 26 58.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results highlight that depletion of Tregs by targeting CD25 might interfere with the induction of adaptive immune responses against brain tumor antigen.
Regulation (targeting) of CD25 in brain associated with brain tumor
1) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.90 Pain Relevance 0.04
Strengthening the role of TLR4 signalling in RA pathogenesis is the observation that serum and synovial fluid from RA patients stimulated TLR4 expressing CHO cells to up-regulate CD25 [51].
Regulation (regulate) of CD25 in synovial fluid associated with rheumatoid arthritis
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.17 Pain Relevance 0.64
CONCLUSIONS: More pronounced analgesic effects obtained by complexation with HPb-CD have shown that both formulations, S50-R50HPb-CD and S75-R25HPb-CD, are very useful for postoperative pain relief, requiring lower LA concentrations.
Regulation (useful) of S75-R25HPb-CD
3) Confidence 0.03 Published 2005 Journal Rev Bras Anestesiol Section Body Doc Link 19471836 Disease Relevance 0 Pain Relevance 0
We observed no changes in the percentage of CD3, CD4, CD8 and CD25 positive lymphocytes in both MTX and NSAID-treated groups.
Neg (no) Regulation (changes) of CD25 in lymphocytes associated with cinod and methotrexate
4) Confidence 0.02 Published 1994 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 7487368 Disease Relevance 0.41 Pain Relevance 0.63
The purpose of this study was to investigate the plasma concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), sIL-2R and transferrin receptor (TfR) in patients with major depression in an acute phase of illness, in remission and during antidepressive treatment.
Spec (investigate) Regulation (concentrations) of sIL-2R in plasma associated with depression
5) Confidence 0.00 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.27 Pain Relevance 0.22
Subchronic treatment with antidepressive drugs, such as fluoxetine or tricyclic antidepressants, did not significantly affect plasma IL-6, sIL-6R, sIL-2R or TfR.
Neg (not) Regulation (affect) of sIL-2R in plasma associated with tricyclic antidepressant and fluoxetine
6) Confidence 0.00 Published 1995 Journal J Affect Disord Section Abstract Doc Link 8550956 Disease Relevance 0.30 Pain Relevance 0.33

General Comments

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