INT47939

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1993
Last Reported 2010
Negated 1
Speculated 11
Reported most in Abstract
Documents 171
Total Number 183
Disease Relevance 87.54
Pain Relevance 39.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 74
leukocyte 16
plasma 8
chest 8
blood 6
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 570 100.00 Very High Very High Very High
Angina 306 100.00 Very High Very High Very High
chemokine 23 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
Dopamine 3 99.94 Very High Very High Very High
agonist 73 99.82 Very High Very High Very High
depression 26 99.64 Very High Very High Very High
adenocard 28 99.58 Very High Very High Very High
lidocaine 14 99.42 Very High Very High Very High
cINOD 54 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 761 100.00 Very High Very High Very High
Cv General 3 Under Development 227 100.00 Very High Very High Very High
Myocardial Infarction 188 100.00 Very High Very High Very High
Adhesions 173 100.00 Very High Very High Very High
Injury 110 100.00 Very High Very High Very High
Heart Rate Under Development 26 100.00 Very High Very High Very High
Apoptosis 285 99.80 Very High Very High Very High
Sickle Cell Anemia 60 99.76 Very High Very High Very High
Depression 22 99.64 Very High Very High Very High
Insulin Resistance 11 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surface expression of P-selectin is known to be a marker of platelet activation in patients with acute coronary syndromes.
Gene_expression (expression) of P-selectin in platelet associated with acute coronary syndrome
1) Confidence 0.76 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 10554084 Disease Relevance 0.17 Pain Relevance 0.07
BACKGROUND: Activation of platelets, which plays an important role in inflammation, has recently been reported to enhance platelet P-selectin expression and form platelet-leukocyte aggregation (PLA).
Gene_expression (expression) of P-selectin in platelets associated with inflammation
2) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527965 Disease Relevance 0.53 Pain Relevance 0.25
Platelet P-selectin expression and PLA formation have been reported to be potential markers of inflammatory diseases such as sepsis, thrombosis, myocardial ischemic disorders and stroke.
Gene_expression (expression) of P-selectin in Platelet associated with inflammation, stroke, disease, lidocaine, thrombosis and sepsis
3) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527965 Disease Relevance 0.58 Pain Relevance 0.27
METHODS: To determine the effect of lidocaine on platelet activation, and on platelet activation-related septic condition (lipopolysaccharide-induced), we treated platelets with lidocaine (0.03-3 mM) and then measured platelet P-selectin expression and PLA.
Gene_expression (expression) of P-selectin in platelet
4) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 19527965 Disease Relevance 0 Pain Relevance 0
We found that lidocaine produced a concentration-dependent inhibition of P-selectin expression and PLA.
Gene_expression (expression) of P-selectin
5) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 19527965 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Our findings may help to elucidate the inhibitory role of lidocaine on platelet P-selectin expression and PLA and infer possible therapeutic targets in the treatment of inflammatory diseases.
Gene_expression (expression) of P-selectin in platelet
6) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 19527965 Disease Relevance 0 Pain Relevance 0
Lidocaine, one of the most commonly used anesthetics, is known to inhibit platelet function, but its effect on platelet P-selectin expression and PLA remains unclear.
Gene_expression (expression) of P-selectin in platelet
7) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527965 Disease Relevance 0.55 Pain Relevance 0.26
The percentage of platelets expressing P-selectin was higher in MI than in UA (9.1 +/- 1.9% vs. 4.2 +/- 0.85%, P = 0.03).
Gene_expression (expressing) of P-selectin in platelets associated with angina and myocardial infarction
8) Confidence 0.76 Published 2001 Journal Thromb. Haemost. Section Abstract Doc Link 11434707 Disease Relevance 1.54 Pain Relevance 0.69
The platelet expression of P-selectin is unrelated to the level found in plasma in patients with acute chest pain, irrespective of the etiology of chest pain.
Gene_expression (expression) of P-selectin in chest associated with angina
9) Confidence 0.76 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947910 Disease Relevance 0.92 Pain Relevance 0.68
In 20 patients with stable angina undergoing coronary stent implantation, circulating PDMPs were serially measured by enzyme-linked immunosorbent assay, and P-selectin expression on the surface of platelets was simultaneously analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of P-selectin in platelets associated with angina
10) Confidence 0.76 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.27 Pain Relevance 0.14
Both circulating PDMPs and P-selectin expression were enhanced in association with stent-induced platelet activation; however, the time course of changes in these two platelet activation markers was different.
Gene_expression (expression) of P-selectin in platelet
11) Confidence 0.76 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.18 Pain Relevance 0.10
Lidocaine priming reduces ADP-induced P-selectin expression and platelet-leukocyte aggregation.
Gene_expression (expression) of P-selectin in leukocyte associated with lidocaine
12) Confidence 0.76 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Title Doc Link 19527965 Disease Relevance 0.53 Pain Relevance 0.27
Therefore, the clinical relevance of circulating PDMPs may differ from that of P-selectin expression on the platelet membrane surface.
Gene_expression (expression) of P-selectin in platelet
13) Confidence 0.76 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.06 Pain Relevance 0.06
Platelet expression of P-selectin (% of cell positivity) was consistently higher for each discharge diagnosis when measured with FACScan flow cytometer (13.2+/-4.1 for myocardial infarction, 10.0+/-3.6 for unstable angina, 9.9+/-3.5 for heart failure, 4.7+/-0.1 for gastrointestinal illness, and 6.3+/-0.7 for patients with noncardiac chest pain) when compared with results obtained from the EPICS XL instrument (2.4+/-0.2, 2.5+/-0.2, 2.5+/-0.1, 1.8+/-0.1, and 2.3+/-0.1 respectively, p=0.0001 for all groups).
Gene_expression (expression) of P-selectin in chest associated with angina and myocardial infarction
14) Confidence 0.76 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 10554084 Disease Relevance 0.71 Pain Relevance 0.35
The relative increase in PDMPs was not correlated with the increase in P-selectin expression at 15 min or 24 h after coronary stenting, but was correlated at 48 h (R = 0.48, P < 0.05).
Gene_expression (expression) of P-selectin
15) Confidence 0.76 Published 2006 Journal Platelets Section Abstract Doc Link 16973503 Disease Relevance 0.20 Pain Relevance 0.10
Comparison of changes in circulating platelet-derived microparticles and platelet surface P-selectin expression after coronary stent implantation.
Gene_expression (expression) of P-selectin in platelet associated with inflammation
16) Confidence 0.76 Published 2006 Journal Platelets Section Title Doc Link 16973503 Disease Relevance 0.27 Pain Relevance 0.18
We examined P-selectin expression on platelets (platelet activation) and leucocyte-platelet aggregate formation in 72 migraine patients during their attack-free interval and controls using a flow cytometric assay.
Gene_expression (expression) of P-selectin in leucocyte associated with migraine
17) Confidence 0.76 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15955041 Disease Relevance 0.73 Pain Relevance 0.66
We sought to determine whether platelet expression of P-selectin correlates with plasma levels in the population of patients presenting to the emergency department with chest pain.
Gene_expression (expression) of P-selectin in chest associated with angina and emergencies
18) Confidence 0.76 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947910 Disease Relevance 0.65 Pain Relevance 0.37
The flow cytometer model markedly affects measurement of ex vivo whole blood platelet-bound P-selectin expression in patients with chest pain: are we comparing apples with oranges.
Gene_expression (expression) of P-selectin in chest associated with angina
19) Confidence 0.76 Published 1999 Journal Thromb. Res. Section Title Doc Link 10554084 Disease Relevance 0.55 Pain Relevance 0.27
It has been reported that platelet expression and plasma levels of soluble P-selectin are increased in patients with unstable coronary artery syndromes.
Gene_expression (expression) of P-selectin in platelet associated with vascular disease
20) Confidence 0.76 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947910 Disease Relevance 0.47 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox