INT47943

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.38
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Glp1r) signal transducer activity (Glp1r)
Anatomy Link Frequency
plasma 4
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 23 99.96 Very High Very High Very High
Clonidine 1 99.36 Very High Very High Very High
Neurotransmitter 4 78.32 Quite High
Dopamine 2 55.20 Quite High
Enkephalin 2 42.00 Quite Low
Dynorphin 2 40.96 Quite Low
Neuropeptide 4 29.12 Quite Low
alcohol 1 6.16 Low Low
ischemia 9 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 99.30 Very High Very High Very High
Diabetes Mellitus 47 97.60 Very High Very High Very High
Pancreatitis 81 93.60 High High
Myocardial Infarction 104 91.60 High High
Cardiovascular Disease 4 76.08 Quite High
Insulin Resistance 14 72.32 Quite High
Hyperglycemia 4 70.48 Quite High
Coronary Artery Disease 1 45.28 Quite Low
Gastric Motility Disorder 1 29.60 Quite Low
Body Weight 13 24.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Food ingestion induces a rapid increase in the insulinotropic glucagon-like peptide-1 (GLP-1) in plasma.
Positive_regulation (induces) of Positive_regulation (increase) of GLP-1 in plasma
1) Confidence 0.70 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7490533 Disease Relevance 0 Pain Relevance 0.14
Clonidine (10(-7) M), an alpha2-agonist, induced a moderate and delayed increase of GLP-1 and PYY but abolished the isoproterenol-induced peptide secretion.
Positive_regulation (induced) of Positive_regulation (increase) of GLP-1 associated with agonist and clonidine
2) Confidence 0.49 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.26
Food ingestion induces a rapid increase in the insulinotropic glucagon-like peptide-1 (GLP-1) in plasma.
Positive_regulation (induces) of Positive_regulation (increase) of glucagon-like peptide-1 in plasma
3) Confidence 0.44 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7490533 Disease Relevance 0 Pain Relevance 0.14
Furthermore, activation of the GLP-1 receptor was required upstream for stimulation of these pathways.
Positive_regulation (required) of Positive_regulation (activation) of GLP-1 receptor
4) Confidence 0.43 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.65 Pain Relevance 0
In patients with T2DM, however, because the insulinotropic effect of GIP may be diminished in this disease, DPP-4 inhibitors are believed to mediate glucose lowering primarily via stabilisation of GLP-1 (5).
Positive_regulation (mediate) of Positive_regulation (stabilisation) of GLP-1 associated with diabetes mellitus and disease
5) Confidence 0.11 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2904489 Disease Relevance 0.73 Pain Relevance 0.05

General Comments

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