INT47949

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 29.78
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ELOVL1) endoplasmic reticulum (ELOVL1)
Anatomy Link Frequency
SSC 1
fibroblasts 1
dorsal horn 1
endothelial cell 1
vessels 1
ELOVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 14 100.00 Very High Very High Very High
rheumatoid arthritis 112 99.80 Very High Very High Very High
Inflammation 139 99.32 Very High Very High Very High
Dorsal horn neuron 10 98.52 Very High Very High Very High
Pain 30 98.00 Very High Very High Very High
Spinal cord 4 97.96 Very High Very High Very High
Arthritis 112 95.56 Very High Very High Very High
Dorsal horn 2 95.52 Very High Very High Very High
psoriasis 4 94.56 High High
fibrosis 91 91.44 High High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 1473 100.00 Very High Very High Very High
Infection 126 100.00 Very High Very High Very High
Interstitial Lung Diseases 55 100.00 Very High Very High Very High
Mycobacterial Infection 40 100.00 Very High Very High Very High
Hypersensitivity 13 100.00 Very High Very High Very High
Shock 5 100.00 Very High Very High Very High
Bordatella Infection 2 100.00 Very High Very High Very High
Hypoxia 12 99.90 Very High Very High Very High
Rheumatoid Arthritis 117 99.80 Very High Very High Very High
Pulmonary Disease 26 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The methods were identical in both studies and the same set of population-based control individuals was used as the referent group for the UCTD cases as was used for the SSc cases.
Positive_regulation (used) of SSc associated with systemic sclerosis and disease
1) Confidence 0.42 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 1.56 Pain Relevance 0.03
We could also postulate an altered immune system or unknown co-factor increasing the risk of both tuberculosis (TB) and SSc.
Positive_regulation (increasing) of SSc in immune system associated with mycobacterial infection and systemic sclerosis
2) Confidence 0.42 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 2.00 Pain Relevance 0
If there was recall bias, we would have expected it to occur in favour of our hypothesis of increased infection in SSc; however, this was not the case.
Positive_regulation (increased) of SSc associated with systemic sclerosis and infection
3) Confidence 0.42 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.59 Pain Relevance 0.06
Insofar as SSc has appreciable mortality in severe cases, however, the absence of increased mortality in this large body of epidemiological evidence should appropriately be viewed as providing no evidence that solvent exposure is associated with increased risk of fatal SSc.


Positive_regulation (increased) of SSc in body associated with systemic sclerosis
4) Confidence 0.39 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 1.35 Pain Relevance 0
Chloroform exposure (in a man repairing carburetors for 13 years) has been implicated as a cause for SSc by Tibon-Fisher [32].
Positive_regulation (cause) of SSc associated with systemic sclerosis
5) Confidence 0.39 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.85 Pain Relevance 0
We hypothesized that direct stimulation of the SSC will inhibit the activity of spinal dorsal horn neurons by activating the descending inhibitory system.
Positive_regulation (stimulation) of SSC in dorsal horn associated with primary somatosensory cortex and dorsal horn neuron
6) Confidence 0.34 Published 2005 Journal Brain Res. Section Abstract Doc Link 16122710 Disease Relevance 0.36 Pain Relevance 0.59
It is concluded that electrical stimulation of the SSC produces transient inhibition of the responses of spinal cord dorsal horn neurons to higher intensity mechanical stimuli without affecting innocuous stimuli.
Positive_regulation (stimulation) of SSC in SSC associated with primary somatosensory cortex, dorsal horn neuron and spinal cord
7) Confidence 0.34 Published 2005 Journal Brain Res. Section Abstract Doc Link 16122710 Disease Relevance 0.38 Pain Relevance 0.58
Circumstantial evidence for a probable infectious cause (via an immune cross-reactivity mechanism where increased activation of a gene regulating the synthesis of a heat shock protein (HSP) in SSc fibroblasts) has been described [9].
Positive_regulation (increased) of SSc in fibroblasts associated with shock and systemic sclerosis
8) Confidence 0.30 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.85 Pain Relevance 0
In one report of long-standing SSc with the presence of cryoglobulins (both IgG and IgM), the patient presented with paresthesias, transient aphasia, vision changes, and delirium [30] (Table 2).
Positive_regulation (standing) of SSc associated with dysesthesia, delirium, systemic sclerosis and aphasia
9) Confidence 0.28 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2952802 Disease Relevance 1.74 Pain Relevance 0.16
Self-report of infections prior to diagnosis in SSc is not increased compared to non-inflammatory controls.
Neg (not) Positive_regulation (increased) of SSc associated with inflammation, systemic sclerosis and infection
10) Confidence 0.28 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.44 Pain Relevance 0.05
BACKGROUND: In systemic sclerosis (SSc), digital ulcers (DU) are painful, difficult to heal and frequently infected, thus greatly affecting quality of life and increasing SSc-related disability.
Positive_regulation (increasing) of SSc-related associated with pain, ulcers and systemic sclerosis
11) Confidence 0.13 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 19796562 Disease Relevance 0.54 Pain Relevance 0.14
To test whether the lower conductance in response to heat in the SSc group was just a consequence of lower microvascular density, we normalized the thermal hyperhemia to the endothelium-independent nitroglycerin response.
Spec (whether) Positive_regulation (conductance) of SSc in endothelium associated with systemic sclerosis
12) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257434 Disease Relevance 0.30 Pain Relevance 0
We still need to determine in future studies whether the abnormal response to local heating in SSc and RA differs with respect to the pathogenic mechanisms.
Spec (whether) Positive_regulation (response) of SSc associated with rheumatoid arthritis and systemic sclerosis
13) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257434 Disease Relevance 1.17 Pain Relevance 0.26
Although this trial did not succeed in demonstrating that bosentan improved or stabilized SSc-ILD, it did initiate debate on validation of the 6 MWD test in SSc and suggested that there is a need for measures that are sufficiently sensitive to changes throughout the duration of the study [20].


Positive_regulation (stabilized) of SSc-ILD associated with interstitial lung diseases and systemic sclerosis
14) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072887 Disease Relevance 1.98 Pain Relevance 0
It is likely that autoantibodies will play an important role as far as subclassification of SSc and its response to therapy are concerned.
Positive_regulation (response) of SSc associated with systemic sclerosis
15) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072887 Disease Relevance 0.86 Pain Relevance 0.09
Plasma levels are elevated in SSc patients, particularly those with PAH or ILD, and ET-1 is over-expressed in as-yet-uninvolved and early-involved skin [15].
Positive_regulation (elevated) of SSc in skin associated with interstitial lung diseases, pulmonary hypertension and systemic sclerosis
16) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072887 Disease Relevance 1.46 Pain Relevance 0.13
During our follow up period two patients in the ACA-/SS group and another two in the SSc/(+) sicca subgroup developed lymphoma, while four patients died, all of which had SSc.
Positive_regulation (had) of SSc associated with lymphatic system cancer, sjoegrens syndrome, syndrome and systemic sclerosis
17) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888196 Disease Relevance 2.30 Pain Relevance 0
The 5 SSc health states were: mild SSc, moderate SSc, moderate SSc with lung disease, severe SSc, and severe SSc with lung disease.
Positive_regulation (severe) of SSc in lung associated with pulmonary disease and systemic sclerosis
18) Confidence 0.02 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2959096 Disease Relevance 2.71 Pain Relevance 0.34
Recent therapeutic advances suggest common pathogenic mechanisms and a role for endothelin receptor activation in SSc-associated vasculopathy.2 However, endothelin receptor blockers such as the dual endothelin receptor type A/B blocker bosentan are effective in the prevention of DUs, but are not able to heal DUs, indicating different mechanisms for prevention and ulcer healing.3 Intravenous iloprost is often used for the treatment of DUs, but its effect on the prevention of DUs has not been studied to date.
Positive_regulation (activation) of SSc-associated associated with ulcers and systemic sclerosis
19) Confidence 0.01 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2938897 Disease Relevance 1.28 Pain Relevance 0
The overproduced MMP-9 may induce microvascular damage and leakage of substances that further augment endothelial cell damage or fibroblast activation in SSc.
Positive_regulation (activation) of SSc in endothelial cell associated with systemic sclerosis
20) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.68 Pain Relevance 0.50

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