INT47950

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 20.33
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ELOVL1) endoplasmic reticulum (ELOVL1)
Anatomy Link Frequency
lung 2
spinal 1
blood vessels 1
lymphocyte 1
fingers 1
ELOVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 83 100.00 Very High Very High Very High
anesthesia 18 99.62 Very High Very High Very High
epidural 16 99.40 Very High Very High Very High
Catecholamine 1 96.12 Very High Very High Very High
headache 12 92.00 High High
ischemia 156 89.28 High High
nud 70 76.88 Quite High
agonist 2 75.00 Quite High
aspirin 4 73.20 Quite High
Pain 57 68.64 Quite High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 919 100.00 Very High Very High Very High
Pulmonary Hypertension 42 100.00 Very High Very High Very High
Pulmonary Fibrosis 32 100.00 Very High Very High Very High
Hypersensitivity 3 100.00 Very High Very High Very High
Ulcers 207 99.96 Very High Very High Very High
Syndrome 319 99.76 Very High Very High Very High
Disease 311 99.60 Very High Very High Very High
Sjoegrens Syndrome 70 99.16 Very High Very High Very High
Apoptosis 9 98.24 Very High Very High Very High
Obesity 6 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A finding of interest was a substantial proportion of patients with isolated pulmonary hypertension without lung fibrosis both in the dcSSc and lcSSc subsets (27.7% vs 60%; P < 0.001).
Negative_regulation (proportion) of SSc in lung associated with fibrosis, pulmonary hypertension and pulmonary fibrosis
1) Confidence 0.41 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468885 Disease Relevance 1.62 Pain Relevance 0.19
OBJECTIVE: Our study had 3 aims: (1) to evaluate the functioning of the Symptom Burden Index (SBI) in patients with systemic sclerosis (SSc); (2) to determine the amount of burden per problem experienced by patients as well as the number of patients experiencing each measured problem area, and the number of SSc problems per patient; and (3) to characterize the burden profiles of problem area-specific subgroups of patients.
Negative_regulation (evaluate) of SSc associated with systemic sclerosis
2) Confidence 0.31 Published 2010 Journal J. Rheumatol. Section Abstract Doc Link 20516027 Disease Relevance 0.37 Pain Relevance 0
Given that IgG antibodies have been found at increased levels in certain herpes viruses in scleroderma [2], and herpes viruses have been detected in SSc patients in several case studies [18, 22], and that studies have found sequence homologies between herpes virus and endogenous proteins [21], the possible association between herpes viruses and SSc merits further research.
Negative_regulation (detected) of SSc associated with herpes simplex virus and systemic sclerosis
3) Confidence 0.26 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.43 Pain Relevance 0.03
One case of PACNS has been described in SSc [29] (Table 2).
Negative_regulation (described) of SSc associated with systemic sclerosis
4) Confidence 0.24 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2952802 Disease Relevance 1.74 Pain Relevance 0.17
This paper summarizes the current knowledge regarding the risk factors, pathogenesis, evaluation, and treatment of digital ischemic loss in SSc.


1.

Negative_regulation (loss) of SSc associated with systemic sclerosis
5) Confidence 0.13 Published 2010 Journal International Journal of Rheumatology Section Abstract Doc Link PMC2943156 Disease Relevance 0.70 Pain Relevance 0.09
In addition, antibodies against novel autoantigens expressed in the cytotoxic lymphocyte granule pathway have been associated with the clinical phenotype of ischemic digital loss in SSc.
Negative_regulation (loss) of SSc in lymphocyte associated with systemic sclerosis
6) Confidence 0.13 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2943156 Disease Relevance 0.71 Pain Relevance 0.03
A recent study investigated whether anti-beta2-glycoprotein I (anti-beta2-glycoprotein I antibodies) and aCL antibodies are correlated with macrovascular disease, including digital loss in SSc patients.
Spec (whether) Negative_regulation (loss) of SSc associated with systemic sclerosis and disease
7) Confidence 0.13 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2943156 Disease Relevance 1.42 Pain Relevance 0.03
The process of revascularization is also defective in SSc, affecting both angiogenesis, in which new vessels arise from preexisting vessels, and vasculogenesis, in which new vessels derive from endothelial progenitor cells to replace damaged or senescent blood vessels, despite elevated levels of angiogenic factors.
Negative_regulation (defective) of SSc in blood vessels associated with systemic sclerosis
8) Confidence 0.12 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2943156 Disease Relevance 1.23 Pain Relevance 0.14
A finding of interest was a substantial proportion of patients with isolated pulmonary hypertension without lung fibrosis both in the dcSSc and lcSSc subsets (27.7% vs 60%; P < 0.001).
Negative_regulation (proportion) of lcSSc in lung associated with fibrosis, pulmonary hypertension and pulmonary fibrosis
9) Confidence 0.09 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468885 Disease Relevance 1.63 Pain Relevance 0.19
In this report we present a very rare case of combined spinal-epidural anesthesia in a patient with SSc whose pulmonary function tests were decreased with low exercise capacity.


Negative_regulation (decreased) of SSc in spinal associated with anesthesia, epidural and systemic sclerosis
10) Confidence 0.06 Published 2006 Journal BMC Anesthesiol Section Body Doc Link PMC1629007 Disease Relevance 0.84 Pain Relevance 0.25
According to ACR classification, 34 patients had limited cutaneous SSc and 4 had diffuse cutaneous SSc.
Negative_regulation (limited) of SSc associated with systemic sclerosis
11) Confidence 0.04 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 1.83 Pain Relevance 0.03
Although the postprandial gallbladder emptying profile was fully comparable in SSc patients vs. both dyspeptic and healthy controls, gallbladder refilling was impaired in SSc patients and dyspeptic controls, compared to healthy controls (Figure 2).
Negative_regulation (impaired) of SSc associated with systemic sclerosis
12) Confidence 0.04 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 0.97 Pain Relevance 0.04
In total, counting in the two cases from our cohort, 15 out of 66 patients (23%) initially presenting with ACA+/SS eventually developed SSc.
Negative_regulation (developed) of SSc associated with syndrome and systemic sclerosis
13) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888196 Disease Relevance 1.97 Pain Relevance 0.03
Another three patients with Raynaud's phenomenon, puffy fingers, ACA and sicca manifestations at first visit eventually developed SSc, after 3, 9 and 24 months respectively, but never fulfilled criteria for SS.


Negative_regulation (developed) of SSc in fingers associated with syndrome, sjoegrens syndrome and systemic sclerosis
14) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888196 Disease Relevance 2.49 Pain Relevance 0.03
An open-label study of 14 SSc patients showed that 12 weeks of atorvastatin improved the Raynaud's severity and prevented new SSc-DUs [44].
Negative_regulation (prevented) of SSc associated with ulcers
15) Confidence 0.01 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2939434 Disease Relevance 0.92 Pain Relevance 0.07
At the same concentrations in atria from saline-treated chicks, carbachol's negative inotropic effect on the steady state contractions (SSC) is attenuated and the rested state contraction (RSC) is increased.
Negative_regulation (effect) of SSC associated with hypersensitivity
16) Confidence 0.00 Published 1995 Journal Life Sci. Section Abstract Doc Link 7491095 Disease Relevance 0.46 Pain Relevance 0.09

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