INT47958

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.44
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
synovial fluid 1
cardiovascular system 1
internal 1
fibroblast 1
ITS (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 10 100.00 Very High Very High Very High
Cholecystokinin 19 99.90 Very High Very High Very High
Central nervous system 5 99.68 Very High Very High Very High
Dismenorea 1 96.72 Very High Very High Very High
analgesia 1 96.36 Very High Very High Very High
Dopamine 1 95.76 Very High Very High Very High
rheumatoid arthritis 18 94.12 High High
Neuropeptide 1 93.36 High High
Osteoarthritis 16 93.16 High High
Peripheral nervous system 2 90.44 High High
Disease Link Frequency Relevance Heat
Endometriosis 2 96.72 Very High Very High Very High
Anxiety Disorder 1 96.72 Very High Very High Very High
Mycoses 2 96.12 Very High Very High Very High
Cancer 2 95.24 Very High Very High Very High
Pancreatitis 2 95.12 Very High Very High Very High
Rheumatoid Arthritis 18 94.12 High High
Osteoarthritis 16 93.16 High High
Adhesions 1 90.72 High High
Sprains And Strains 73 80.40 Quite High
Leishmaniasis 8 78.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Using Northern blot analysis, in situ hybridization, and immunohistochemistry, the expression of uPA, its receptor (uPAR), plasminogen activator inhibitor 1 (PAI-1), and transforming growth factor beta 1 (TGF-beta 1) was studied in 14 patients undergoing pancreatic resection for CP.
Gene_expression (expression) of its
1) Confidence 0.75 Published 1997 Journal Gastroenterology Section Body Doc Link 9287983 Disease Relevance 0.10 Pain Relevance 0
This study was undertaken to characterize the expression of both uPA and its receptor (uPAR) in the eutopic and heterotopic endometrial cells from women with adenomyosis by testing both types of epithelial cells for invasive ability.
Gene_expression (expression) of its in epithelial cells associated with dismenorea
2) Confidence 0.75 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.37 Pain Relevance 0.10
Dogs were recruited with informed consent from owners in villages of the Heraklion prefecture within 15 km radius of the city of Heraklion, on the criteria of being negative to all diagnostic tests: (1) Indirect immunofluorescent antibody test (IFAT) [29], (2) Crude Leishmania parasite antigen (CLA) ELISA [30], and (3) PCR of buffy coat to detect DNA expressing the internal transcribed spacer 1 region of the ribosomal RNA gene (ITS-1 rRNA) of Leishmania spp. [31].
Gene_expression (expressing) of ITS in internal
3) Confidence 0.65 Published 2009 Journal Vaccine Section Body Doc Link PMC2663027 Disease Relevance 0.36 Pain Relevance 0
Fig. 2.Phylogeny of Clade I obtained from a ML analysis of three combined loci
(ITS rDNA, EF1-? 
Gene_expression (rDNA) of ITS
4) Confidence 0.65 Published 2008 Journal Studies in Mycology Section Body Doc Link PMC2610306 Disease Relevance 0.13 Pain Relevance 0
Fig. 3.Phylogeny of Clade II obtained from a ML analysis of three combined loci
(ITS rDNA, EF1-? 
Gene_expression (rDNA) of ITS
5) Confidence 0.65 Published 2008 Journal Studies in Mycology Section Body Doc Link PMC2610306 Disease Relevance 0.18 Pain Relevance 0
U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues.
Gene_expression (expressed) of its in cardiovascular system associated with central nervous system
6) Confidence 0.58 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18191840 Disease Relevance 0.14 Pain Relevance 0.12
METHODS: There were 21 specimens of lumbar intervertebral discs from 15 patients with discogenic low back pain during posterior lumbar interbody fusion, 16 aging discs from patients without low back pain, and 10 normal discs as control collected for the study of their histopathologic features, as well as the expressions of basic fibroblast growth factor (bFGF) and its receptor (Flg), transforming growth factor-beta1 (TGF-beta1) and its receptor (TGF-betaRI) by immunohistochemistry.
Gene_expression (expressions) of its in fibroblast
7) Confidence 0.58 Published 2006 Journal Spine Section Body Doc Link 16508552 Disease Relevance 0 Pain Relevance 0
The aim of our work was to study the levels of SP and its peptidases, neutral endopeptidase (3.4.24.11) (NEP) and angiotensin-converting enzyme (ACE), in the synovial fluid and plasma of 30 patients with RA and 14 patients with osteoarthritis (OA).
Gene_expression (levels) of its in plasma associated with rheumatoid arthritis, osteoarthritis and substance p
8) Confidence 0.58 Published 1993 Journal Rheumatol. Int. Section Abstract Doc Link 8390712 Disease Relevance 1.03 Pain Relevance 0.75
CCK and its receptors are also widely distributed in the central nervous system (CNS) and contribute to the regulation of satiety, anxiety, analgesia, and dopamine-mediated behavior.
Gene_expression (distributed) of its in CNS associated with dopamine, anxiety disorder, central nervous system, cholecystokinin and analgesia
9) Confidence 0.29 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7491953 Disease Relevance 0.10 Pain Relevance 0.81
The aim of our work was to study the levels of SP and its peptidases, neutral endopeptidase (3.4.24.11) (NEP) and angiotensin-converting enzyme (ACE), in the synovial fluid and plasma of 30 patients with RA and 14 patients with osteoarthritis (OA).
Gene_expression (levels) of its in synovial fluid associated with rheumatoid arthritis, osteoarthritis and substance p
10) Confidence 0.20 Published 1993 Journal Rheumatol. Int. Section Abstract Doc Link 8390712 Disease Relevance 1.03 Pain Relevance 0.75

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