INT47972

Context Info Confidence 0.46 First Reported 1995 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 2.09 Pain Relevance 1.53

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA) enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)

Anatomy Link Frequency monocytes 2 NFKBIA (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 12 99.68 cINOD 6 92.48 Inflammation 176 91.12 chemokine 7 83.52 cytokine 26 70.92 rheumatoid arthritis 1 61.36 dexamethasone 4 59.92 corticosteroid 112 50.00 Inflammatory response 114 7.80 Inflammatory stimuli 70 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 98.92 Htlv Types I And Ii 8 93.48 INFLAMMATION 312 91.12 Leukemia 6 85.08 Disease 14 81.04 Retinal Diseases 1 80.44 Systemic Inflammatory Response Syndrome 8 5.00 Injury 6 5.00 Targeted Disruption 4 5.00 Critical Illness 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.

Positive_regulation (induced) of Protein_catabolism (degradation) of I kappa B alpha

1) Confidence 0.46 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.34 Pain Relevance 0.21

Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.

Positive_regulation (increases) of Protein_catabolism (degradation) of IkappaBalpha in monocytes

2) Confidence 0.35 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24

The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].

Positive_regulation (stimulated) of Protein_catabolism (degradation) of IkBa

3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.17 Pain Relevance 0.09

However, its degradation rate depends on the presence of its primary inhibitor (IkBa) as the latter retrieves nuclear concentrations of NFkB by forming an inactive complex in the cytoplasmic region [60].

Positive_regulation (depends) of Protein_catabolism (degradation) of IkBa

4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.21 Pain Relevance 0.11

Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.

Positive_regulation (induced) of Protein_catabolism (degradation) of I kappa-B alpha associated with qutenza

5) Confidence 0.25 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.61 Pain Relevance 0.44

Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.

Positive_regulation (up-regulation) of Protein_catabolism (degradation) of I kappa-B alpha associated with qutenza

6) Confidence 0.25 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.61 Pain Relevance 0.44

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