INT47972

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.09
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
Anatomy Link Frequency
monocytes 2
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 12 99.68 Very High Very High Very High
cINOD 6 92.48 High High
Inflammation 176 91.12 High High
chemokine 7 83.52 Quite High
cytokine 26 70.92 Quite High
rheumatoid arthritis 1 61.36 Quite High
dexamethasone 4 59.92 Quite High
corticosteroid 112 50.00 Quite Low
Inflammatory response 114 7.80 Low Low
Inflammatory stimuli 70 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 98.92 Very High Very High Very High
Htlv Types I And Ii 8 93.48 High High
INFLAMMATION 312 91.12 High High
Leukemia 6 85.08 High High
Disease 14 81.04 Quite High
Retinal Diseases 1 80.44 Quite High
Systemic Inflammatory Response Syndrome 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Critical Illness 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.
Positive_regulation (induced) of Protein_catabolism (degradation) of I kappa B alpha
1) Confidence 0.46 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.34 Pain Relevance 0.21
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Positive_regulation (increases) of Protein_catabolism (degradation) of IkappaBalpha in monocytes
2) Confidence 0.35 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Positive_regulation (stimulated) of Protein_catabolism (degradation) of IkBa
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.17 Pain Relevance 0.09
However, its degradation rate depends on the presence of its primary inhibitor (IkBa) as the latter retrieves nuclear concentrations of NFkB by forming an inactive complex in the cytoplasmic region [60].
Positive_regulation (depends) of Protein_catabolism (degradation) of IkBa
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.21 Pain Relevance 0.11
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
Positive_regulation (induced) of Protein_catabolism (degradation) of I kappa-B alpha associated with qutenza
5) Confidence 0.25 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.61 Pain Relevance 0.44
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
Positive_regulation (up-regulation) of Protein_catabolism (degradation) of I kappa-B alpha associated with qutenza
6) Confidence 0.25 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.61 Pain Relevance 0.44

General Comments

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