INT47976

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.88
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 7.57
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
Anatomy Link Frequency
T98G 1
monocytes 1
HL-60 1
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 31 99.44 Very High Very High Very High
Paracetamol 6 99.02 Very High Very High Very High
aspirin 20 97.54 Very High Very High Very High
Inflammation 468 96.40 Very High Very High Very High
rheumatoid arthritis 60 96.40 Very High Very High Very High
cytokine 80 95.88 Very High Very High Very High
cINOD 49 92.48 High High
metalloproteinase 3 91.00 High High
chemokine 9 81.52 Quite High
COX-2 inhibitor 4 78.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 17 98.44 Very High Very High Very High
Multiple Myeloma 7 98.16 Very High Very High Very High
Leukemia 5 96.80 Very High Very High Very High
INFLAMMATION 742 96.40 Very High Very High Very High
Rheumatoid Arthritis 60 96.40 Very High Very High Very High
Arthropathy 2 94.60 High High
Cancer 20 93.72 High High
Htlv Types I And Ii 4 93.00 High High
Necrosis 10 92.04 High High
Hypercalcemia 4 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Protein_catabolism (degradation) of IkappaBalpha
1) Confidence 0.88 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.15 Pain Relevance 0.38
Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.
Protein_catabolism (degradation) of I kappa B alpha associated with qutenza
2) Confidence 0.82 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.05 Pain Relevance 0.74
Western blot analysis of IkappaBalpha protein in the cytoplasm of IL-1beta-stimulated T98G cells and electrophoretic mobility shift assay (EMSA) on corresponding nuclear extracts indicate that acetaminophen (10-1000 microM) dose-dependently inhibits both IkappaBalpha degradation and NF-kappaB nuclear translocation.
Protein_catabolism (degradation) of IkappaBalpha in T98G associated with paracetamol
3) Confidence 0.81 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.47
IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.
Protein_catabolism (degradation) of IkappaBalpha
4) Confidence 0.69 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.05 Pain Relevance 0
Stimulation of hRPE cells by monocytes resulted in prominent increases in p38, ERK1/2 and JNK/SAPK phosphorolation, IkappaBalpha degradation, and NF-kappaB nuclear translocation.
Protein_catabolism (degradation) of IkappaBalpha in monocytes
5) Confidence 0.69 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.14 Pain Relevance 0.24
Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.
Protein_catabolism (degradation) of I kappa B alpha
6) Confidence 0.66 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.34 Pain Relevance 0.21
Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.
Protein_catabolism (degradation) of IkappaBalpha
7) Confidence 0.62 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.29 Pain Relevance 0.19
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Protein_catabolism (degradation) of IkBa
8) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.17 Pain Relevance 0.09
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
Protein_catabolism (degradation) of I kappa-B alpha associated with qutenza
9) Confidence 0.44 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.61 Pain Relevance 0.44
The protein inhibitor IkBa, as seen in Eq. (3), is the product of translation of its gene transcript (mRNA,IkBa) and it degrades at a rate kI,2 which is stimulated by the kinase activity (IKK).
Protein_catabolism (degrades) of IkBa
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.22 Pain Relevance 0.11
However, its degradation rate depends on the presence of its primary inhibitor (IkBa) as the latter retrieves nuclear concentrations of NFkB by forming an inactive complex in the cytoplasmic region [60].
Protein_catabolism (degradation) of IkBa
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.21 Pain Relevance 0.11
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Protein_catabolism (degradation) of IkBa
12) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.18 Pain Relevance 0.09
These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.
Protein_catabolism (degradation) of IkappaB-alpha
13) Confidence 0.11 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.22 Pain Relevance 0.32
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Protein_catabolism (proteolysis) of IkappaB-alpha associated with aspirin
14) Confidence 0.07 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64
SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.
Protein_catabolism (degradation) of IkappaB-alpha associated with multiple myeloma
15) Confidence 0.06 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.88 Pain Relevance 0.11
RANK signaling was analyzed by the degradation of inhibitor of kappaB-alpha (I-?
Spec (analyzed) Protein_catabolism (degradation) of kappaB-alpha
16) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906801 Disease Relevance 0.98 Pain Relevance 0.38
In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.
Protein_catabolism (degradation) of IkappaB alpha in HL-60 associated with leukemia and qutenza
17) Confidence 0.02 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.52 Pain Relevance 0.54
A variety of provoking stimuli can degrade the IkB and result in the nuclear translocation of NF-kB to be free to activate DNA synthesis of inflammatory cytokines [Figure 2].
Protein_catabolism (degrade) of IkB associated with inflammation and cytokine
18) Confidence 0.02 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.93 Pain Relevance 0.75

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox