INT4798

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Context Info
Confidence 0.77
First Reported 1980
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 169
Total Number 172
Disease Relevance 29.56
Pain Relevance 86.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
nucleus 10
neurons 10
ventral 7
nucleus accumbens 6
striatum 5
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 519 100.00 Very High Very High Very High
Glutamate 426 100.00 Very High Very High Very High
Pain 401 100.00 Very High Very High Very High
medulla 284 100.00 Very High Very High Very High
Enkephalin 265 100.00 Very High Very High Very High
substance P 245 100.00 Very High Very High Very High
opioid receptor 207 100.00 Very High Very High Very High
Neuropeptide 179 100.00 Very High Very High Very High
Neurotransmitter 162 100.00 Very High Very High Very High
Opioid 148 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 181 100.00 Very High Very High Very High
Hypothermia 19 99.96 Very High Very High Very High
Cancer 46 99.76 Very High Very High Very High
Injury 48 99.72 Very High Very High Very High
Stress 68 99.70 Very High Very High Very High
Pain 501 99.52 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 9 99.48 Very High Very High Very High
Nociception 423 99.24 Very High Very High Very High
Hyperalgesia 18 98.96 Very High Very High Very High
Cough 465 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine-containing neurones of the ventral tegmental area express neurotensin receptors which are involved in regulating cell firing and dopamine release.
Gene_expression (express) of neurotensin in ventral associated with ventral tegmentum and dopamine
1) Confidence 0.77 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955721 Disease Relevance 0 Pain Relevance 0.29
Somatostatin, bombesin, neurotensin, enkephalin, and vasoactive-intestinal-polypeptide immunoreactivities were not detected.
Neg (not) Gene_expression (detected) of neurotensin associated with somatostatin and enkephalin
2) Confidence 0.75 Published 1988 Journal J. Neurocytol. Section Abstract Doc Link 2459317 Disease Relevance 0.22 Pain Relevance 0.32
Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.
Gene_expression (expression) of neurotensin/neuromedin N in striatum associated with enkephalin
3) Confidence 0.75 Published 1997 Journal Eur. J. Neurosci. Section Title Doc Link 9421173 Disease Relevance 0 Pain Relevance 0.10
Cellular sites of enkephalin and dopamine and adenylate cyclase phosphoprotein-32 gene expression were identified microscopically by the concentration of purple alkaline phosphatase reaction product within the cell cytoplasm, whereas sites of substance P and proneurotensin gene expression were identified by the dense clustering of silver grains overlying cells.
Gene_expression (expression) of neurotensin associated with dopamine, enkephalin and substance p
4) Confidence 0.75 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135049 Disease Relevance 0 Pain Relevance 0.79
The most striking increases in neurotensin mRNA expression were observed 16-17 days after the onset of nociceptive stimuli.
Gene_expression (expression) of neurotensin mRNA associated with nociception
5) Confidence 0.75 Published 1993 Journal Brain Res. Section Abstract Doc Link 8518953 Disease Relevance 1.27 Pain Relevance 0.66
METH injection did not cause further increases in Nts expression on the side of the lesion when compared to the saline-treated 6-OHDA-injected animals (compare SL to ML group).
Gene_expression (expression) of Nts
6) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.14
Our results showed that a lesion of the nigrostriatal pathway induced the expression of enkephalin, neurotensin, and substance P immunoreactivity in numerous pallidal cell bodies.
Gene_expression (expression) of neurotensin associated with enkephalin and substance p
7) Confidence 0.71 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552872 Disease Relevance 0 Pain Relevance 0.46
Neurotensin produced no significant effect on either basal or stimulated cAMP levels.
Neg (no) Gene_expression (produced) of Neurotensin
8) Confidence 0.68 Published 1984 Journal Brain Res. Section Abstract Doc Link 6098333 Disease Relevance 0 Pain Relevance 0.09
Under voltage-clamp, at holding potentials from -50 to -60 mV (near the resting membrane potential), neurotensin produced a sustained inward shift in the holding current.
Gene_expression (produced) of neurotensin
9) Confidence 0.68 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 7687049 Disease Relevance 0 Pain Relevance 0.11
The peptidase-resistant derivative of neurotensin, [D-Trp11]neurotensin, has been continuously infused intracerebroventricularly (75 ng/h) with an osmotic minipump for 10 days.
Gene_expression (resistant) of neurotensin
10) Confidence 0.67 Published 1994 Journal Peptides Section Abstract Doc Link 8008636 Disease Relevance 0.16 Pain Relevance 0.29
Neurotensin, an endogenous tridecapeptide, produces a potent, naloxone-insensitive antinociceptive response when it is microinjected into the periaqueductal gray region of the rat brainstem.
Gene_expression (produces) of Neurotensin in brainstem associated with medulla, narcan, central grey and antinociceptive
11) Confidence 0.67 Published 1991 Journal Brain Res. Section Abstract Doc Link 1660754 Disease Relevance 0.22 Pain Relevance 0.57
There is evidence that neurotensin receptors exist in this nucleus.
Gene_expression (exist) of neurotensin in nucleus
12) Confidence 0.67 Published 2004 Journal Neuroscience Section Abstract Doc Link 15120846 Disease Relevance 0 Pain Relevance 0.03
Neurotensin also produced a dose-related (0.1-3.3 nmol) increase in dopamine and its metabolites.
Gene_expression (produced) of Neurotensin associated with dopamine
13) Confidence 0.67 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1697899 Disease Relevance 0 Pain Relevance 0.69
The elevation in extracellular dopamine produced by DAMGO, but not by neurotensin, was positively correlated with the increase in motor activity.
Neg (not) Gene_expression (produced) of neurotensin associated with dopamine
14) Confidence 0.67 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1697899 Disease Relevance 0 Pain Relevance 0.75
This observation, plus behavioral data showing that neurotensin injection into the nucleus accumbens blocks some behavioral effects of amphetamine, indicates that neurotensin may modulate the mesolimbic dopamine system.
Gene_expression (injection) of neurotensin in nucleus accumbens associated with nucleus accumbens and dopamine
15) Confidence 0.67 Published 1984 Journal Neuroscience Section Abstract Doc Link 6738859 Disease Relevance 0 Pain Relevance 0.54
In this study it was shown that neurotensin given into the nucleus accumbens produces a dose-dependent blockade of locomotion and rearing initiated by dopamine injection into the nucleus accumbens.
Gene_expression (produces) of neurotensin in nucleus accumbens associated with nucleus accumbens and dopamine
16) Confidence 0.67 Published 1984 Journal Neuroscience Section Abstract Doc Link 6738859 Disease Relevance 0 Pain Relevance 0.69
When administered into the cerebroventricular system of the rat, neurotensin (NT) produces a variety of effects, including a decrease in colonic temperature and an increase in nociceptive threshold.
Gene_expression (produces) of neurotensin associated with nociception
17) Confidence 0.65 Published 1982 Journal J. Comp. Neurol. Section Abstract Doc Link 7142439 Disease Relevance 0.17 Pain Relevance 0.07
Cellular sites of proneurotensin messenger RNA expression were visualized simultaneously on tissue sections processed to reveal cellular sites of preproenkephalin A messenger RNA or the dopamine and adenylate cyclase phosphoprotein-32, messenger RNA.
Gene_expression (expression) of neurotensin associated with dopamine
18) Confidence 0.65 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135049 Disease Relevance 0 Pain Relevance 0.33
Activation of the VTA dopamine (DA) system may produce reinforcing effects in general because (a) neurotensin is self-administered into the VTA, and injection of neurotensin into the VTA produces CPP and enhances DA release in the nucleus accumbens (NAC), and (b) GABA(A) antagonists are self-administered into the anterior VTA and injections of GABA(A) antagonists into the anterior VTA enhance DA release in the NAC.
Gene_expression (injection) of neurotensin in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, gaba, dopamine and antagonist
19) Confidence 0.65 Published 1999 Journal Behav. Brain Res. Section Abstract Doc Link 10372570 Disease Relevance 0 Pain Relevance 1.64
Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.
Gene_expression (expression) of neurotensin/neuromedin N in striatum associated with enkephalin
20) Confidence 0.65 Published 1997 Journal Eur. J. Neurosci. Section Title Doc Link 9421173 Disease Relevance 0 Pain Relevance 0.10

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