INT47987

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
THP-1 2
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 99.30 Very High Very High Very High
cINOD 2 99.24 Very High Very High Very High
rheumatoid arthritis 2 77.68 Quite High
cytokine 2 70.16 Quite High
fibrosis 2 47.68 Quite Low
Piles 1 27.76 Quite Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 3 100.00 Very High Very High Very High
Radiation Sickness 1 99.32 Very High Very High Very High
INFLAMMATION 8 99.30 Very High Very High Very High
Cancer 26 93.40 High High
Toxicity 18 92.96 High High
Disease 4 88.52 High High
Vascular System Injuries 1 86.00 High High
Rhabdomyosarcoma 1 73.64 Quite High
Glioblastoma 1 64.68 Quite High
Injury 1 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report that a family of anti-inflammatory agents, known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses.
Negative_regulation (inhibited) of Positive_regulation (induction) of TF in THP-1 associated with inflammation
1) Confidence 0.57 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.35 Pain Relevance 0.17
In contrast, two other nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, did not inhibit LPS induction of the TF gene.
Negative_regulation (inhibit) of Positive_regulation (induction) of TF gene associated with inflammation and cinod
2) Confidence 0.57 Published 1995 Journal Blood Section Abstract Doc Link 7492771 Disease Relevance 0.32 Pain Relevance 0.21
Pentoxifylline inhibits the hypoxia induced upregulation of Tissue Factor (TF) a procoagulant stimulus known to upregulate VEGF and angiogenesis [60].
Negative_regulation (inhibits) of Positive_regulation (upregulation) of TF associated with hypoxia
3) Confidence 0.10 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 1.01 Pain Relevance 0.08

General Comments

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