INT48

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 69
Total Number 74
Disease Relevance 12.47
Pain Relevance 18.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
sympathetic nervous system 14
blood 12
kidney 8
renal nerve 8
plasma 4
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 71 100.00 Very High Very High Very High
ketamine 12 100.00 Very High Very High Very High
Catecholamine 3 100.00 Very High Very High Very High
Clonidine 43 99.98 Very High Very High Very High
adenocard 22 99.78 Very High Very High Very High
narcan 17 99.56 Very High Very High Very High
cocaine 13 99.52 Very High Very High Very High
Intracerebroventricular 6 99.52 Very High Very High Very High
tetrodotoxin 15 99.32 Very High Very High Very High
Versed 8 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 38 100.00 Very High Very High Very High
Hypoaldosteronism 1 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 8 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.96 Very High Very High Very High
Natriuresis 8 99.90 Very High Very High Very High
Bordatella Infection 18 99.78 Very High Very High Very High
Pressure And Volume Under Development 9 99.32 Very High Very High Very High
Disorder Of Lipid Metabolism 1 97.84 Very High Very High Very High
Hypotension 7 97.72 Very High Very High Very High
Heart Rate Under Development 6 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consistent with the hypothesis that veratrine stimulates renin secretion by at least two mechanisms.
Positive_regulation (stimulates) of Localization (secretion) of renin
1) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.21
It is well known that norepinephrine released from the renal nerves stimulates the secretion of renin by a beta adrenergic mechanism.
Positive_regulation (stimulates) of Localization (secretion) of renin in renal nerves
2) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.10
We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release.
Positive_regulation (stimulated) of Localization (secretion) of renin in renal nerve associated with tetrodotoxin
3) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.21
Moreover, veratrine stimulated renin secretion in slices prepared from previously denervated kidneys; this response was not antagonized by timolol.
Positive_regulation (stimulated) of Localization (secretion) of renin
4) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.20
Veratrine (10-200 microM) stimulated renin secretion in a concentration-dependent manner.
Positive_regulation (stimulated) of Localization (secretion) of renin
5) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.13
We conclude that the tetrodotoxin-sensitive component of veratrine-stimulated renin secretion in this preparation is an in vitro model of renal nerve-stimulated renin secretion; it should be useful in investigating substances which affect renin secretion by presynaptic modulation of transmitter release.
Positive_regulation (stimulated) of Localization (secretion) of renin in renal nerve associated with tetrodotoxin
6) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6368797 Disease Relevance 0 Pain Relevance 0.20
This anesthesia-induced renin release and the extensive biologic activities of angiotensin and aldosterone suggest a potential for influencing many investigations, particularly those involving cardiovascular and endocrine systems.
Positive_regulation (induced) of Localization (release) of renin in endocrine systems associated with anesthesia
7) Confidence 0.70 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1129282 Disease Relevance 0 Pain Relevance 0.39
Renin release by two anesthetic agents (ketamine and urethane) appeared to be mediated premarily through the beta-adrenermediated primarily through the beta-adrenergic receptor mechanism, but equivocal results were obtained with other agents (pentobarbital and morphine).
Positive_regulation (mediated) of Localization (release) of Renin associated with ketamine and morphine
8) Confidence 0.70 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1129282 Disease Relevance 0 Pain Relevance 0.39
Propranolol impaired most of the anesthesia-induced renin release and impaired aldosterone release with the one agent (urethane) studied.
Positive_regulation (induced) of Localization (release) of renin associated with anesthesia
9) Confidence 0.70 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1129282 Disease Relevance 0 Pain Relevance 0.36
The results indicate that the responses of plasma renin activity to immobilization and head-up tilt are due to increased secretion of renin mediated by the sympathetic nervous system.
Positive_regulation (increased) of Localization (secretion) of renin in sympathetic nervous system
10) Confidence 0.70 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.24
On the other hand, the increase in secretion of renin produced by inactin anesthesia does not appear to be mediated by the sympathetic nervous system.
Positive_regulation (increase) of Localization (secretion) of renin in sympathetic nervous system associated with anesthesia
11) Confidence 0.70 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.24
Pharmacological evidence that the sympathetic nervous system mediates the increase in renin secretion produced by immobilization and head-up tilt in rats.
Positive_regulation (increase) of Localization (secretion) of renin in head
12) Confidence 0.70 Published 1988 Journal Neuropharmacology Section Title Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.22
Two minutes after BNX and corresponding stimulation of renin secretion by anesthesia and surgery, plasma renin concentration was increased disproportionately compared with myocardial renin.
Positive_regulation (stimulation) of Localization (secretion) of renin in plasma associated with anesthesia
13) Confidence 0.70 Published 1997 Journal Hypertension Section Abstract Doc Link 9260990 Disease Relevance 0 Pain Relevance 0.10
However, the results of the studies using methysergide suggest that serotonin appears to act at a point prior to activation of beta-adrenoceptors in the pathway leading to release of renin from the kidneys.
Positive_regulation (leading) of Localization (release) of renin associated with serotonin
14) Confidence 0.69 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6356172 Disease Relevance 0 Pain Relevance 0.50
Increased endogenous PG-levels were associated with only a modest (insignificant) increase in renin release under the present conditions.
Positive_regulation (increase) of Localization (release) of renin
15) Confidence 0.69 Published 1981 Journal Acta Physiol. Scand. Section Abstract Doc Link 6797255 Disease Relevance 0.16 Pain Relevance 0.03
Pertussis toxin: a) increased significantly basal renin secretion, b) displaced to the left the concentration-response curve for isoproterenol and epinephrine and magnified the response to epinephrine and c) abolished the inhibitory effect of clonidine on renin secretion.
Positive_regulation (increased) of Localization (secretion) of renin associated with bordatella infection and clonidine
16) Confidence 0.69 Published 1986 Journal Life Sci. Section Abstract Doc Link 3005789 Disease Relevance 0.35 Pain Relevance 0.19
Pertussis toxin potentiates anesthesia-induced renin secretion.
Positive_regulation (induced) of Localization (secretion) of renin associated with anesthesia
17) Confidence 0.68 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 3894036 Disease Relevance 0.29 Pain Relevance 0.30
The anesthetics increased renin secretion and this effect was markedly magnified in rats treated with pertussis toxin.
Positive_regulation (increased) of Localization (secretion) of renin associated with bordatella infection
18) Confidence 0.68 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3894036 Disease Relevance 0.27 Pain Relevance 0.17
We conclude that exposure of rats in utero and during lactation to doses of Pb which produce blood Pb concentrations similar to those generally present in human populations stimulates basal renin secretion in 1-month-old rats, but partially inhibits the response to renin-releasing stimuli.
Positive_regulation (stimulates) of Localization (secretion) of renin in blood
19) Confidence 0.68 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6338501 Disease Relevance 0.07 Pain Relevance 0.08
The opiate antagonist naloxone (0.1-10 mg/kg i.p.) and the acetylcholinesterase inhibitor diisopropyl fluorophosphate (0.5 mg/kg i.p.) did not block stress-induced renin or prolactin secretion.
Positive_regulation (induced) of Localization (secretion) of renin associated with stress, antagonist, narcan and opiate
20) Confidence 0.66 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 0.94 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox