INT48004

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 4.07
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
plasma 2
monocytes 2
nerve 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 42 100.00 Very High Very High Very High
diclofenac 4 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Analgesic 10 99.68 Very High Very High Very High
aspirin 30 99.66 Very High Very High Very High
rheumatoid arthritis 2 98.78 Very High Very High Very High
Potency 1 97.52 Very High Very High Very High
Inflammation 15 96.28 Very High Very High Very High
cytokine 5 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Renal Failure 1 99.96 Very High Very High Very High
Ulcers 2 98.86 Very High Very High Very High
Rheumatoid Arthritis 2 98.78 Very High Very High Very High
Cirrhosis 7 98.72 Very High Very High Very High
Gastritis 1 95.76 Very High Very High Very High
Toxicity 4 94.76 High High
Cancer 1 91.60 High High
Necrosis 1 91.36 High High
Arthralgia 1 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains to be investigated whether mechanisms other than inhibition of cyclooxygenase contribute to the analgesic activity of lysine clonixinate.
Spec (whether) Positive_regulation (contribute) of Spec (whether) Negative_regulation (inhibition) of cyclooxygenase associated with analgesic
1) Confidence 0.49 Published 1996 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 8866627 Disease Relevance 0.07 Pain Relevance 0.41
DATA SYNTHESIS: Several controlled pharmacodynamic studies indicate that the sustained inhibition of cyclooxygenase activity by aspirin is blunted in the presence of some NSAIDs.
Positive_regulation (blunted) of Negative_regulation (inhibition) of cyclooxygenase
2) Confidence 0.47 Published 2005 Journal Ann Pharmacother Section Body Doc Link 15870140 Disease Relevance 0 Pain Relevance 0
We tested the hypothesis that acute inhibition of cyclooxygenase (COX), the rate-limiting enzyme in prostanoid synthesis, impairs baroreflex regulation of cardiac period (R-R interval) and muscle sympathetic nerve activity (MSNA) in humans and augments pressor reactivity.
Positive_regulation (augments) of Negative_regulation (inhibition) of cyclooxygenase in nerve
3) Confidence 0.42 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15486039 Disease Relevance 0 Pain Relevance 0.18
Inhibition of PGHS-1(Arg120-->Glu) was time-dependent for diclofenac and time-independent for DuP697, as observed for the wild type enzyme, indicating that the mutation does not alter the basic mechanism of inhibition.
Positive_regulation (time-dependent) of Negative_regulation (Inhibition) of PGHS associated with diclofenac
4) Confidence 0.37 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7493972 Disease Relevance 0.14 Pain Relevance 0.44
Inhibition of PGHS-1(Arg120-->Glu) was time-dependent for diclofenac and time-independent for DuP697, as observed for the wild type enzyme, indicating that the mutation does not alter the basic mechanism of inhibition.
Positive_regulation (time-independent) of Negative_regulation (Inhibition) of PGHS associated with diclofenac
5) Confidence 0.37 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7493972 Disease Relevance 0.14 Pain Relevance 0.45
Cyclooxygenase inhibition in human monocytes increases endotoxin-induced TNF alpha without affecting cyclooxygenase-2 expression.
Positive_regulation (increases) of Negative_regulation (inhibition) of Cyclooxygenase in monocytes associated with cox2
6) Confidence 0.22 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15464057 Disease Relevance 0.18 Pain Relevance 0.24
Nonselective inhibition of cyclooxygenase (COX) by nonsteroidal anti-inflammatory drugs frequently induces renal failure in decompensated cirrhosis.
Positive_regulation (induces) of Negative_regulation (inhibition) of cyclooxygenase associated with cirrhosis, inflammation, renal failure and cinod
7) Confidence 0.22 Published 2005 Journal Hepatology Section Abstract Doc Link 15723448 Disease Relevance 0.62 Pain Relevance 0.13
The responses were also examined in the presence of opioid receptor blocker, nitric oxide synthase inhibitor, beta-adrenoceptor blocker, or cyclooxygenase inhibitor.
Spec (examined) Positive_regulation (presence) of Negative_regulation (inhibitor) of cyclooxygenase associated with opioid receptor
8) Confidence 0.19 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11273940 Disease Relevance 0 Pain Relevance 0.54
Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray?
Positive_regulation (Update) of Negative_regulation (inhibitors) of cyclooxygenase
9) Confidence 0.13 Published 2005 Journal Curr Med Res Opin Section Title Doc Link 16083531 Disease Relevance 0.18 Pain Relevance 0.38
Although misoprostol can prevent NSAID-induced ulcers, it does not ameliorate all physiological perturbations induced by cyclooxygenase inhibition.
Positive_regulation (induced) of Negative_regulation (inhibition) of cyclooxygenase associated with ulcers and cinod
10) Confidence 0.11 Published 1995 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7769193 Disease Relevance 0.10 Pain Relevance 0.15
Most of the aspirin-like maleimides inactivated the cyclooxygenase activity of purified ovine PGHS-1 in a time- and concentration-dependent manner similar to that of aspirin.
Positive_regulation (inactivated) of Negative_regulation (inactivated) of PGHS-1 associated with aspirin
11) Confidence 0.11 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8648609 Disease Relevance 0.10 Pain Relevance 0.24
This is mediated through reversible inhibition of the cyclooxygenase-1 and 2 (COX-1 and 2) enzymes.
Positive_regulation (mediated) of Negative_regulation (inhibition) of cyclooxygenase-1 and 2
12) Confidence 0.10 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846149 Disease Relevance 1.21 Pain Relevance 1.15
Inhibition of cytokine production may help to explain the incremental therapeutic benefit of NSAIDs observed in the treatment of rheumatoid arthritis at plasma drug concentrations substantially higher than are required to inhibit prostaglandin G/H synthase (cyclooxygenase).
Positive_regulation (required) of Negative_regulation (inhibit) of cyclooxygenase in plasma associated with rheumatoid arthritis, cinod and cytokine
13) Confidence 0.02 Published 1998 Journal Nature Section Abstract Doc Link 9422509 Disease Relevance 0.55 Pain Relevance 0.69
These toxicities are thought to be due to cyclooxygenase (COX)-1 blockade.
Positive_regulation (due) of Negative_regulation (blockade) of cyclooxygenase
14) Confidence 0.01 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16787194 Disease Relevance 0.78 Pain Relevance 0.87

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