INT48006
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
A higher dose (30 microg) of nor-BNI blocked phosphoramidon, sufentanil, and U-50,488H, suggesting a loss of kappa-opioid receptor selectivity at this dose. | |||||||||||||||
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Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression. | |||||||||||||||
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Surprisingly when KOR was impaired in knockout mice or by NorBNI treatment, proliferation of stem cells and microglia was not evident in Vp. | |||||||||||||||
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Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors. | |||||||||||||||
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Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors. | |||||||||||||||
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Ethanol treatment, particularly in combination with cocaine, reduces KOR mRNA in the VTA of rats (11). | |||||||||||||||
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It has been shown that the behavioural responses to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR). | |||||||||||||||
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It has been shown that the behavioural responses to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR). | |||||||||||||||
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Mice deficient in the kappa-opioid receptor (KOR) gene have recently been developed by the technique of homologous recombination and shown to lack behavioural responses to the selective kappa1-receptor agonist U-50,488H. | |||||||||||||||
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Mice deficient in the kappa-opioid receptor (KOR) gene have recently been developed by the technique of homologous recombination and shown to lack behavioural responses to the selective kappa1-receptor agonist U-50,488H. | |||||||||||||||
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Cloning of OPRK1 upstream regions | |||||||||||||||
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KOR was constitutively expressed in postnatal day 19 (P19) embryonal carcinoma stem cells and is suppressed by NO donors [sodium nitroprusside (SNP), 3-morpholinosydnonimine-1, and S-nitrosoglutathione] in P19 stem cells within 4 hr. | |||||||||||||||
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Mice lacking mu- (MOR), delta- (DOR) and kappa- (KOR) opioid receptors have been generated and some specific pharmacological effects induced by cannabinoids have been reported to be modified in these animals. | |||||||||||||||
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Brain opioid systems have been implicated in the regulation of social interaction, including agonistic behaviour. kappa-Opioid receptor B and C mRNA levels were decreased in the ventral tegmental area but not in the nucleus accumbens in male mice with repeated experience of social victories (winners), but not in mice after social defeats (losers) after 10 but not 20 days of confrontations. mu-Opioid receptor mRNA levels were not changed. | |||||||||||||||
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The antinociceptive effect of a selective kappa-opioid receptor agonist R-84760, (3R)-3-(1-pyrrolidinylmethyl)-4-[(1S)-5,6-dichloro-1-indancarbo nyl]- tetrahydro-1,4-thiazine hydrochloride, in the second phase of the formalin test, a model of tonic pain, was examined in mice. | |||||||||||||||
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Blocking the KOR in mice that normally drink ethanol (C57/BL6) with a KOR-specific antagonist, nor-binaltorphimine, increases alcohol self-administration (8). | |||||||||||||||
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Mice homozygous for a disruption in Oprk1 drink less ethanol in a two-bottle choice paradigm than either wild-type or heterozygous mice (10), however, suggesting that complete deletion of the KOR reduces drinking in mice, but a 50% reduction in KOR levels may not affect it. | |||||||||||||||
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The selective KOR-agonists U-69593 (5 and 25 mg kg(-1), s.c.) and asimadoline (25 mg kg(-1), s.c.) significantly decreased the VMR in KOR(+/+) mice, while having no effect in KOR(-/-) mice. | |||||||||||||||
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Effects of KOR inhibition on astrocytic Responses | |||||||||||||||
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Blocking the KOR increases voluntary ethanol intake in C57/BL6 mice (8). | |||||||||||||||
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