INT48006

Context Info Confidence 0.58 First Reported 1995 Last Reported 2010 Negated 0 Speculated 4 Reported most in Abstract Documents 27 Total Number 35 Disease Relevance 10.14 Pain Relevance 19.11

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)

Anatomy Link Frequency visceral 2 nervous tissues 2 astrocytes 2 stem cells 2 microglia 1 Oprk1 (Mus musculus)

Pain Link Frequency Relevance Heat Kappa opioid receptor 577 100.00 alcohol 187 100.00 opioid receptor 138 100.00 agonist 63 100.00 antagonist 55 100.00 mu opioid receptor 3 100.00 Antinociceptive 11 99.98 cocaine 6 99.96 Peripheral nervous system 80 99.70 Dynorphin 99 99.68

Disease Link Frequency Relevance Heat Embryonal Carcinoma 1 100.00 Targeted Disruption 50 99.96 Body Weight 20 99.68 Nociception 31 99.32 Thymoma 10 99.26 Pruritus 3 97.72 Alcohol Addiction 177 97.28 Aggression 2 97.00 Pain 23 96.88 Sprains And Strains 11 96.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A higher dose (30 microg) of nor-BNI blocked phosphoramidon, sufentanil, and U-50,488H, suggesting a loss of kappa-opioid receptor selectivity at this dose.

Negative_regulation (loss) of kappa-opioid receptor associated with kappa opioid receptor

1) Confidence 0.58 Published 2007 Journal Life Sci. Section Abstract Doc Link 17379253 Disease Relevance 0 Pain Relevance 1.14

Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression.

Negative_regulation (Decrease) of kappa-opioid receptor mRNA in ventral associated with ventral tegmentum, aggression and kappa opioid receptor

2) Confidence 0.56 Published 2005 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15857692 Disease Relevance 0.10 Pain Relevance 0.37

Surprisingly when KOR was impaired in knockout mice or by NorBNI treatment, proliferation of stem cells and microglia was not evident in Vp.

Negative_regulation (impaired) of KOR in microglia associated with targeted disruption and kappa opioid receptor

3) Confidence 0.51 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.44 Pain Relevance 0.51

Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors.

Spec (examined) Negative_regulation (disruption) of KOR associated with targeted disruption, kappa opioid receptor and alcohol

4) Confidence 0.43 Published 2005 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 15897716 Disease Relevance 0.35 Pain Relevance 0.40

Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors.

Spec (examined) Negative_regulation (disruption) of kappa-opioid receptor associated with targeted disruption, kappa opioid receptor and alcohol

5) Confidence 0.43 Published 2005 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 15897716 Disease Relevance 0.35 Pain Relevance 0.40

Ethanol treatment, particularly in combination with cocaine, reduces KOR mRNA in the VTA of rats (11).

Negative_regulation (reduces) of KOR mRNA associated with opioid receptor and cocaine

6) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.18 Pain Relevance 1.13

It has been shown that the behavioural responses to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR).

Negative_regulation (lacking) of kappa-opioid receptor in visceral associated with targeted disruption, nociception and kappa opioid receptor

7) Confidence 0.43 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18643891 Disease Relevance 0.27 Pain Relevance 0.50

It has been shown that the behavioural responses to chemically evoked visceral nociception are increased in transgenic mice lacking the kappa-opioid receptor (KOR).

Negative_regulation (lacking) of KOR in visceral associated with targeted disruption, nociception and kappa opioid receptor

8) Confidence 0.43 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18643891 Disease Relevance 0.27 Pain Relevance 0.50

Mice deficient in the kappa-opioid receptor (KOR) gene have recently been developed by the technique of homologous recombination and shown to lack behavioural responses to the selective kappa1-receptor agonist U-50,488H.

Negative_regulation (deficient) of KOR associated with agonist and kappa opioid receptor

9) Confidence 0.43 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082819 Disease Relevance 0.15 Pain Relevance 0.31

Mice deficient in the kappa-opioid receptor (KOR) gene have recently been developed by the technique of homologous recombination and shown to lack behavioural responses to the selective kappa1-receptor agonist U-50,488H.

Negative_regulation (deficient) of kappa-opioid receptor associated with agonist and kappa opioid receptor

10) Confidence 0.43 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082819 Disease Relevance 0.15 Pain Relevance 0.31

Cloning of OPRK1 upstream regions

Negative_regulation (Cloning) of OPRK1

11) Confidence 0.43 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.11 Pain Relevance 0

KOR was constitutively expressed in postnatal day 19 (P19) embryonal carcinoma stem cells and is suppressed by NO donors [sodium nitroprusside (SNP), 3-morpholinosydnonimine-1, and S-nitrosoglutathione] in P19 stem cells within 4 hr.

Negative_regulation (suppressed) of KOR in stem cells associated with kappa opioid receptor and embryonal carcinoma

12) Confidence 0.42 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.10 Pain Relevance 0.22

Mice lacking mu- (MOR), delta- (DOR) and kappa- (KOR) opioid receptors have been generated and some specific pharmacological effects induced by cannabinoids have been reported to be modified in these animals.

Negative_regulation (lacking) of KOR associated with cannabinoid and opioid receptor

13) Confidence 0.41 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622180 Disease Relevance 0.13 Pain Relevance 0.60

Brain opioid systems have been implicated in the regulation of social interaction, including agonistic behaviour. kappa-Opioid receptor B and C mRNA levels were decreased in the ventral tegmental area but not in the nucleus accumbens in male mice with repeated experience of social victories (winners), but not in mice after social defeats (losers) after 10 but not 20 days of confrontations. mu-Opioid receptor mRNA levels were not changed.

Negative_regulation (decreased) of kappa-Opioid receptor B in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, opioid receptor and opioid

14) Confidence 0.41 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15857692 Disease Relevance 0.07 Pain Relevance 0.37

The antinociceptive effect of a selective kappa-opioid receptor agonist R-84760, (3R)-3-(1-pyrrolidinylmethyl)-4-[(1S)-5,6-dichloro-1-indancarbo nyl]- tetrahydro-1,4-thiazine hydrochloride, in the second phase of the formalin test, a model of tonic pain, was examined in mice.

Spec (examined) Negative_regulation (effect) of kappa-opioid receptor associated with pain, agonist, kappa opioid receptor and antinociceptive

15) Confidence 0.39 Published 1995 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7494383 Disease Relevance 0.09 Pain Relevance 0.57

Blocking the KOR in mice that normally drink ethanol (C57/BL6) with a KOR-specific antagonist, nor-binaltorphimine, increases alcohol self-administration (8).

Negative_regulation (Blocking) of KOR associated with antagonist, opioid receptor and alcohol

16) Confidence 0.38 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.16 Pain Relevance 0.94

Mice homozygous for a disruption in Oprk1 drink less ethanol in a two-bottle choice paradigm than either wild-type or heterozygous mice (10), however, suggesting that complete deletion of the KOR reduces drinking in mice, but a 50% reduction in KOR levels may not affect it.

Negative_regulation (reduction) of KOR associated with opioid receptor

17) Confidence 0.38 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.69 Pain Relevance 0.74

The selective KOR-agonists U-69593 (5 and 25 mg kg(-1), s.c.) and asimadoline (25 mg kg(-1), s.c.) significantly decreased the VMR in KOR(+/+) mice, while having no effect in KOR(-/-) mice.

Negative_regulation (decreased) of KOR associated with agonist and kappa opioid receptor

18) Confidence 0.38 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18643891 Disease Relevance 0.21 Pain Relevance 1.18

Effects of KOR inhibition on astrocytic Responses

Negative_regulation (inhibition) of KOR associated with kappa opioid receptor

19) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.15 Pain Relevance 0.49

Blocking the KOR increases voluntary ethanol intake in C57/BL6 mice (8).

Negative_regulation (Blocking) of KOR associated with opioid receptor

20) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.50 Pain Relevance 0.58

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