INT48008

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Context Info
Confidence 0.15
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.12
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde6b)
Anatomy Link Frequency
body 2
neurons 1
lung 1
vascular endothelium 1
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 100.00 Very High Very High Very High
Kappa opioid receptor 3 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Antinociceptive 7 99.98 Very High Very High Very High
sodium channel 15 99.96 Very High Very High Very High
nav1.8 2 99.92 Very High Very High Very High
Nav1.9 4 99.48 Very High Very High Very High
dorsal root ganglion 6 98.16 Very High Very High Very High
Inflammation 15 97.68 Very High Very High Very High
conotoxin 2 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 15 99.54 Very High Very High Very High
Diabetes Mellitus 18 99.22 Very High Very High Very High
Nociception 8 98.60 Very High Very High Very High
Ganglion Cysts 6 98.16 Very High Very High Very High
INFLAMMATION 14 97.68 Very High Very High Very High
Asthma 10 97.08 Very High Very High Very High
Hypersensitivity 2 96.72 Very High Very High Very High
Pain 4 95.80 Very High Very High Very High
Hypoxia 45 95.36 Very High Very High Very High
Stress 22 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, there are single nucleotide polymorphisms resulting in increased or decreased GSNO-R activity that appear to be associated with both increased and decreased asthma risk respectively [30].
Negative_regulation (decreased) of GSNO-R associated with asthma
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.81 Pain Relevance 0.06
For example, if there is decreased GSNO-R activation by eNOS or an androgen-mimetic effect to decrease GSNO-R activity in the female pulmonary vascular endothelium, by virtue of increased eNOS activity and the resulting chronic nitrosative stress, females will be at increased risk for hypoxia-mimetic pulmonary vascular remodeling.
Negative_regulation (decrease) of GSNO-R in vascular endothelium associated with stress and hypoxia
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.95 Pain Relevance 0.10
Indeed, mice deficient in eNOS have reduced GSNO-R activity, and S-nitrosylation increases GSNO-R activity, suggesting that estrogen-dependent increases in eNOS lead to increased GSNO-R activity in the female lung, protecting against excessive S-nitrosylation.
Negative_regulation (reduced) of GSNO-R in lung
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.80 Pain Relevance 0.06
The antinociceptive effect of a selective kappa-opioid receptor agonist R-84760, (3R)-3-(1-pyrrolidinylmethyl)-4-[(1S)-5,6-dichloro-1-indancarbo nyl]- tetrahydro-1,4-thiazine hydrochloride, in the second phase of the formalin test, a model of tonic pain, was examined in mice.
Spec (examined) Negative_regulation (effect) of R-84760 associated with pain, agonist, kappa opioid receptor and antinociceptive
4) Confidence 0.12 Published 1995 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7494383 Disease Relevance 0.09 Pain Relevance 0.60
As a consequence of the reduction of TTX-R VGSC currents, t-MrVIa transgenic mice display decreased inflammatory mechanical hypersensitivity, cold pain insensitivity and reduced firing of cutaneous C-fibres sensitive to noxious cold temperatures.
Negative_regulation (reduction) of TTX-R associated with targeted disruption, c fibre, inflammation, hypersensitivity, sodium channel and pain insensitivity
5) Confidence 0.09 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20308253 Disease Relevance 0.74 Pain Relevance 0.84
T-MrVIa transgenic mice show a 44 +/- 7% reduction of tetrodotoxin-resistant (TTX-R) VGSC current densities.
Negative_regulation (reduction) of TTX-R associated with targeted disruption, tetrodotoxin and sodium channel
6) Confidence 0.06 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20308253 Disease Relevance 0.65 Pain Relevance 0.81
The mixed model regression analyses revealed that elevated PM2.5 levels were consistently associated with declines in rMSSD, SDNN, and SDNNi over the 24-hr, day, and night periods after adjusting for HRV during matched time-periods of nonworkdays, age, and smoking status (Table 3).
Negative_regulation (declines) of rMSSD associated with nicotine addiction
7) Confidence 0.03 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1913585 Disease Relevance 0.16 Pain Relevance 0
This elevated HR response was accompanied by a significantly reduced rMSSD, a measure of beat-to-beat HRV.
Negative_regulation (reduced) of rMSSD
8) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2516564 Disease Relevance 0.62 Pain Relevance 0.12
Although we had sufficient power to link decreased night rMSSD and workday particulate exposures, we did not observe statistical significance among the other night measures.
Negative_regulation (decreased) of rMSSD
9) Confidence 0.02 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1913585 Disease Relevance 0.07 Pain Relevance 0
The mice with diabetes mellitus induced by alloxan were administrated rAPSL (3.0 mg/kg body wt) for four weeks, then the FBG levels were notably decreased to 11.44 ± 6.03 mmol/L (P < 0.001 vs. model).
Negative_regulation (decreased) of rAPSL in body associated with diabetes mellitus
10) Confidence 0.02 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707046 Disease Relevance 0.55 Pain Relevance 0.04
Compared with the ALT level of the model group, those level of serum ALT in the groups treated with rAPSL (3.0 mg/kg body wt and 1.0 mg/kg body wt) were decreased by 61.5% and 44.1%, respectively.
Negative_regulation (decreased) of rAPSL in body
11) Confidence 0.02 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707046 Disease Relevance 0.25 Pain Relevance 0
Using whole-cell patch-clamp recording, we observed a greater than two-fold reduction of tetrodotoxin-resistant (TTX-R) Nav1.8 and Nav1.9 current densities in IB4+ DRG neurons cultured from CNTN-/- vs.
Negative_regulation (reduction) of TTX-R in neurons associated with dorsal root ganglion, tetrodotoxin, nav1.8 and nav1.9
12) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.44 Pain Relevance 1.47

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