INT48009

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Context Info
Confidence 0.68
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 38
Total Number 48
Disease Relevance 15.03
Pain Relevance 11.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde6b)
Anatomy Link Frequency
lung 4
retinas 2
somatotropes 2
neuronal 2
neurons 2
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 51 100.00 Very High Very High Very High
tetrodotoxin 18 100.00 Very High Very High Very High
sodium channel 12 100.00 Very High Very High Very High
Nav1.9 9 100.00 Very High Very High Very High
nav1.8 4 100.00 Very High Very High Very High
Antinociceptive 7 99.16 Very High Very High Very High
Nicotine 9 98.44 Very High Very High Very High
antinociception 6 98.08 Very High Very High Very High
Pain 136 98.04 Very High Very High Very High
Kappa opioid receptor 16 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 112 100.00 Very High Very High Very High
Convulsion 30 98.76 Very High Very High Very High
Nociception 10 98.76 Very High Very High Very High
Pain 146 98.04 Very High Very High Very High
Hypertension 308 97.96 Very High Very High Very High
Targeted Disruption 48 97.12 Very High Very High Very High
Asthma 25 97.04 Very High Very High Very High
Sprains And Strains 324 96.12 Very High Very High Very High
Pulmonary Disease 57 95.60 Very High Very High Very High
Disease 76 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pups were treated with either WTS or rd1S ODNs (Table 1) that were synthesized and purified by the Emory University Microchemical Facility (Atlanta, Georgia).
Gene_expression (synthesized) of rd1S
1) Confidence 0.68 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0.06
We recently demonstrated that the rd1 mutation can be corrected in vitro by gene repair in non-ocular cell lines using locked nucleic acids (LNAs) and phosphorothioate ODNs designed to correct the point mutation in the ?
Gene_expression (mutation) of rd1
2) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0.37 Pain Relevance 0
For normalization calculations, parallel reactions using aliquots of the same source of template DNA were run using primers designed to amplify both wild type and rd1 mutant ?
Gene_expression (mutant) of rd1
3) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Genotypic changes induced in rd1 retinas treated with WTS
Gene_expression (retinas) of rd1 in retinas
4) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Scn11a, the gene for the TTX-R Na+ channel Nav1.9, was predominantly expressed in small and medium sized neuronal profiles in naïve mice, with only a minor percentage (highest in the CBA strain) in larger neurons.
Gene_expression (expressed) of TTX-R in neuronal associated with sprains and strains and nav1.9
5) Confidence 0.63 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.33 Pain Relevance 0.52
For rod photoreceptor cells, these previously characterized molecular markers were cGMP-specific phosphodiesterase 6b (Pde6b; Hurwitz et al., 1985; Baehr et al., 1991; Chang et al., 2007b), cyclic nucleotide gated channel ?
Gene_expression (al.) of Pde6b in photoreceptor cells
6) Confidence 0.61 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.04
M WTS ODN-treated rd1 eye sections, a positive fluorescent signal for ?
Gene_expression (sections) of rd1 in eye
7) Confidence 0.59 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Genomic DNA from rd1 retinas of mice treated with WTS was extracted from individual whole flat-mount retinas (PN28) using a DNeasy Tissue kit and eluted in 200 ?
Gene_expression (retinas) of rd1 in retinas
8) Confidence 0.59 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
M,N: Section of rd1 animals heterozygous for the rod-specific gene PDE6b infected with a control virus expressing only nuclear GFP (pQC-H2BGFP-IX).
Gene_expression (animals) of rd1
9) Confidence 0.54 Published 2008 Journal Developmental Dynamics Section Body Doc Link PMC2532702 Disease Relevance 0.25 Pain Relevance 0
The following targeting sequence was used for the PDE6b shRNA construct: 5?
Gene_expression (shRNA) of PDE6b
10) Confidence 0.54 Published 2008 Journal Developmental Dynamics Section Body Doc Link PMC2532702 Disease Relevance 0.29 Pain Relevance 0
M,N: Section of rd1 animals heterozygous for the rod-specific gene PDE6b infected with a control virus expressing only nuclear GFP (pQC-H2BGFP-IX).
Gene_expression (heterozygous) of PDE6b
11) Confidence 0.54 Published 2008 Journal Developmental Dynamics Section Body Doc Link PMC2532702 Disease Relevance 0.31 Pain Relevance 0
However, a direct comparison between the tau-lacZ+/+ and wild-type and rd1 animals is not possible because in the tau-lacZ+/+ mice only about one half of the melanopsin ipRGC population expresses ?
Gene_expression (animals) of rd1
12) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.06 Pain Relevance 0.06
Scn10a, the gene for the TTX-R Na+ channel Nav1.8, was expressed mostly in neuronal profiles of small and medium size in naïve mice.
Gene_expression (expressed) of TTX-R in neuronal associated with nav1.8
13) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.12 Pain Relevance 0.63
Analyses were performed in brain regions that express Pdyn mRNA and/or KOP-R and that might participate in seizure circuitry: the piriform cortex, olfactory tubercle, nucleus accumbens, caudate-putamen, claustrum, dorsal endopiriform nucleus, and cingulate cortex.
Gene_expression (express) of KOP-R in piriform cortex associated with nucleus accumbens and convulsion
14) Confidence 0.37 Published 2005 Journal Brain Res. Section Abstract Doc Link 15869750 Disease Relevance 0.40 Pain Relevance 0.58
Gender differences in the activity and/or expression of GSNO-R have been suggested.
Gene_expression (expression) of GSNO-R
15) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.86 Pain Relevance 0.09
The current studies evaluate the relationship between gender and the activity and/or expression of GSNO-R in the lung.
Gene_expression (expression) of GSNO-R in lung
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.78 Pain Relevance 0.08
No significant differences in GSNO-R protein expression were seen in the lung homogenates of adult male and female animals.


Gene_expression (expression) of GSNO-R in lung
17) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0 Pain Relevance 0
Possible changes in the expression of KOP-r were investigated in tolerant mice to nicotine antinociception by using autoradiography of [3H]CI-977 binding.
Gene_expression (expression) of KOP-r associated with antinociception and nicotine
18) Confidence 0.26 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221370 Disease Relevance 0 Pain Relevance 1.25
The effects of gender hormones on the expression and activity of the de-nitrosylating enzyme S-nitrosoglutathione reductase (GSNO-R) are undefined.
Gene_expression (expression) of GSNO-R
19) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.34 Pain Relevance 0
This report evaluates the effects of gender hormones on the activity and expression of GSNO-R and its relationship to N-acetyl cysteine (NAC)-induced pulmonary hypertension (PH).
Gene_expression (expression) of GSNO-R associated with hypertension
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.35 Pain Relevance 0

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