INT48042

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Context Info
Confidence 0.50
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.64
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Anxa1) cilium (Anxa1) protein complex (Anxa1)
cytoplasm (Anxa1) extracellular space (Anxa1) signal transduction (Anxa1)
Anatomy Link Frequency
T cells 2
external 1
Anxa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 36 100.00 Very High Very High Very High
substance P 18 94.88 High High
antagonist 40 86.12 High High
Sciatic nerve 9 83.12 Quite High
Inflammation 30 80.08 Quite High
c fibre 1 69.00 Quite High
qutenza 1 67.92 Quite High
Neuropeptide 6 66.56 Quite High
Peripheral nervous system 4 57.68 Quite High
Multiple sclerosis 3 47.28 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 36 100.00 Very High Very High Very High
Disease 5 100.00 Very High Very High Very High
Pressure And Volume Under Development 5 99.24 Very High Very High Very High
Stress 48 95.00 High High
INFLAMMATION 29 80.08 Quite High
Immunization 5 76.76 Quite High
Neurogenic Inflammation 1 75.00 Quite High
Syndrome 4 66.20 Quite High
Multiple Sclerosis 3 49.12 Quite Low
Demyelinating Disease 3 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of lipocortin-1 were also measured in active EAN but occurred during the recovery phase (0.65 +/- 0.27 micrograms/mg protein).
Positive_regulation (Increased) of lipocortin-1 associated with neuritis
1) Confidence 0.50 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10603033 Disease Relevance 0.75 Pain Relevance 0.77
In tissue extracts, lipocortin-1 levels increased from 0.24 +/- 0.14 micrograms/mg protein in controls receiving non-pathogenic T cells to a maximum of 0.55 +/- 0.1 micrograms/mg protein in AT-EAN at the peak of disease, and then slowly decreased during clinical recovery but still remained elevated.
Positive_regulation (increased) of lipocortin-1 in T cells associated with disease and neuritis
2) Confidence 0.50 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10603033 Disease Relevance 1.05 Pain Relevance 0.92
In tissue extracts, lipocortin-1 levels increased from 0.24 +/- 0.14 micrograms/mg protein in controls receiving non-pathogenic T cells to a maximum of 0.55 +/- 0.1 micrograms/mg protein in AT-EAN at the peak of disease, and then slowly decreased during clinical recovery but still remained elevated.
Positive_regulation (elevated) of lipocortin-1 in T cells associated with disease and neuritis
3) Confidence 0.50 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10603033 Disease Relevance 1.10 Pain Relevance 1.07
Topical glucocorticoid inhibited neurogenic oedema formation partly through a mechanism dependent upon lipocortin 1.
Positive_regulation (dependent) of lipocortin 1 associated with pressure and volume under development
4) Confidence 0.47 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7498310 Disease Relevance 0.55 Pain Relevance 0.39
Annexin-1 is expressed in FS cells and glucocorticoids appear to mobilise annexin-1 to the external cell surface.
Positive_regulation (mobilise) of annexin-1 in external
5) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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